Ginkgolide A - Moligand™, 10mM in DMSO , Antagonist of PAF receptor, CAS No.15291-75-5, Antagonist of PAF receptor

CAS: 15291-75-5 Cat. No.: G407818 Molecular Weight: 408.4 EC Number: 604-873-4

GRADE & PURITY Moligand™, 10mM in DMSO

Synonyms

BN52020 | (1R,​3S,​3aS,​4R,​6aR,​7aR,​7bR,​8S,​10aS,​11aS)​-3-​(1,​1-​dimethylethyl)​hexahydro-​4,​7b-​dihydroxy-​8-​methyl-9H-​1,​7a-​(epoxymethano)​-​1H,​6aH-​cyclopenta[c]​furo[2,​3-​b]​furo[3',​2':3,​4]​cyclopenta[1,​2-​d]​furan-​5,​9,​12(4H)​-​trione

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

Information

Ginkgolide A Ginkgolide A (BN52020) is an extract from in Ginkgo biloba and a g-aminobutyric acid (GABA) antagonist with a K i of 14.5 μM.
In vitro

In vivo

Cell Data

cell lines：

Concentrations：

Incubation Time：

Powder Purity:≥95%

Specifications

Synonyms

BN52020 | (1R, ​3S, ​3aS, ​4R, ​6aR, ​7aR, ​7bR, ​8S, ​10aS, ​11aS)​-3-​(1, ​1-​dimethylethyl)​hexahydro-​4, ​7b-​dihydroxy-​8-​methyl-9H-​1, ​7a-​(epoxymethano)​-​1H, ​6aH-​cyclopenta[c]​furo[2, ​3-​b]​furo[3', ​2':3, ​4]​cyclopenta[1, ​2-​d]​furan-​5, ​9, ​12(4H)​-​trione

Specifications & Purity

Moligand™, 10mM in DMSO

Biochemical and Physiological Mechanisms

Ginkgolide A (BN52020) is an extract from in Ginkgo biloba and a g-aminobutyric acid (GABA) antagonist with a K_i of 14.5 μM.

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Grade

Moligand™

Action Type

ANTAGONIST

Mechanism of action

Antagonist of PAF receptor

Names and Identifiers

• Isomeric SMILES: CC1C(=O)OC2C1(C34C(=O)OC5C3(C2)C6(C(C5)C(C)(C)C)C(C(=O)OC6O4)O)O
• WGK Germany: 3
• Molecular Weight: 408.4
• Reaxy-Rn: 9155792
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=9155792&ln=

Associated Targets(Human)

PTAFR Tchem Platelet-activating factor receptor (1 Activities)

Discover Target: PTAFR

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

References

1. Yuan Gang Zu, Lingling Wang, Xiuhua Zhao, Yuanyuan Li, Weiwei Wu, Chang Zu, Yannian Huang, Mingfang Wu, Ziqi Feng.  (2016)  Purification of Ginkgo biloba Extract by Antisolvent Recrystallization.  CHEMICAL ENGINEERING & TECHNOLOGY,  39  (7): (1301-1308).  [PMID:] [10.1002/ceat.201500691]

2. Meng Wang, Xiangling Sun, Ying Wang, Xuan Deng, Jianing Miao, Donghe Zhao, Kunqi Sun, Minrui Li, Xiaoyi Wang, Wenlong Sun, Jie Qin.  (2022)  Construction of Selenium Nanoparticle-Loaded Mesoporous Silica Nanoparticles with Potential Antioxidant and Antitumor Activities as a Selenium Supplement.  ACS Omega,      [PMID:36530304] [10.1021/acsomega.2c04975]

3. Lingling Wang, Xiuhua Zhao, Fengjian Yang, Weiwei Wu, Yanjie Liu, Li Wang, Lu Wang, Zijian Wang.  (2019)  Enhanced bioaccessibility in vitro and bioavailability of Ginkgo biloba extract nanoparticles prepared by liquid anti-solvent precipitation.  INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY,  54  (6): (2266-2276).  [PMID:] [10.1111/ijfs.14141]

4. Lingling Wang, Xiuhua Zhao, Yuangang Zu, Weiwei Wu, Yuanyuan Li, Chang Zu, Yin Zhang.  (2016)  Enhanced dissolution rate and oral bioavailability of ginkgo biloba extract by preparing nanoparticles via emulsion solvent evaporation combined with freeze drying (ESE-FR).  RSC Advances,  6  (81): (77346-77357).  [PMID:] [10.1039/C6RA14771B]