GRADE & PURITY 10mM in DMSO

Synonyms

2-[4,5-Dihydroxy-2-[[12-hydroxy-17-(2-hydroxy-6-methylhept-5-en-2-yl)-4,4,8,10,14-pentamethyl-2,3,5,6,7,9,11,12,13,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl]oxy]-6-(hydroxymethyl)oxan-3-yl]oxy-6-hydroxymethyl)oxane-3,4,5-triol

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Specifications

Synonyms

2-[4, 5-Dihydroxy-2-[[12-hydroxy-17-(2-hydroxy-6-methylhept-5-en-2-yl)-4, 4, 8, 10, 14-pentamethyl-2, 3, 5, 6, 7, 9, 11, 12, 13, 15, 16, 17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl]oxy]-6-(hydroxymethyl)oxan-3-yl]oxy-6-hydroxymethyl)oxane-3, 4, 5-triol

Specifications & Purity

10mM in DMSO

Biochemical and Physiological Mechanisms

Natural triterpenoid saponin found in Panax notoginseng . Shows a variety of biological activities. Shows anti-tumor activity and suppresses COX-2 expression. Inhibits brain Na + currents (IC 50 = 32 μM). Modulatory role in neuroinflammation.

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Names and Identifiers

• Molecular Weight: 785.01
• Reaxy-Rn: 27844255
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=27844255&ln=

References

1. Zeng Xiangfeng, Liu Shengyao, Yang Hua, Jia Menglei, Liu Wei, Zhu Wenting.  (2023)  Synergistic anti-tumour activity of ginsenoside Rg3 and doxorubicin on proliferation, metastasis and angiogenesis in osteosarcoma by modulating mTOR/HIF-1α/VEGF and EMT signalling pathways.  JOURNAL OF PHARMACY AND PHARMACOLOGY,      [PMID:37498992] [10.1093/jpp/rgad070]

2. Ren Rongfan, Li Hongli, Jiang Qing, Wang Xing, Chen David Da Yong.  (2022)  Characterization of ginsenoside structural isomers from mixtures using in situ methylation with direct analysis in real-time ionization tandem mass spectrometry.  ANALYTICAL AND BIOANALYTICAL CHEMISTRY,  415  (5): (887-897).  [PMID:36571591] [10.1007/s00216-022-04482-w]

3. Tianhua Liu, Ling Zuo, Dongqing Guo, Xinlou Chai, Jie Xu, Zhaorui Cui, Zhiyi Wang, Chunying Hou.  (2019)  Ginsenoside Rg3 regulates DNA damage in non-small cell lung cancer cells by activating VRK1/P53BP1 pathway.  BIOMEDICINE & PHARMACOTHERAPY,      [PMID:31629252] [10.1016/j.biopha.2019.109483]

4. Nan Zhao, Mengchun Cheng, Shuai Huang, Dan Liu, Qiang Zhao, Yunpeng Bai, Xiaozhe Zhang.  (2019)  Various Multicharged Anions of Ginsenosides in Negative Electrospray Ionization with QTOF High-Resolution Mass Spectrometry.  JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY,      [PMID:30644055] [10.1007/s13361-018-2089-5]

5. Xiaonan Zhang, Kang Chen, Bo Wei, Xingwang Liu, Zeming Lei, Xizhuang Bai.  (2016)  Ginsenosides Rg3 attenuates glucocorticoid-induced osteoporosis through regulating BMP-2/BMPR1A/Runx2 signaling pathway.  CHEMICO-BIOLOGICAL INTERACTIONS,      [PMID:27387537] [10.1016/j.cbi.2016.07.003]

6. Xinyi Lv, Yuehan Song, Tianhua Liu, Dingdan Zhang, Xinpeng Ye, Qingqing Wang, Rongrong Li, Jiayi Chen, Shujing Zhang, Xue Yu, Chunying Hou.  (2025)  Ginsenoside Rg3 Adjunctively Increases the Efficacy of Gefitinib Against NSCLC by Regulating EGFR Copy Number.  Pharmaceuticals,  18  (7): (1077).  [PMID:40732366] [10.3390/ph18071077]