GSK 591 dihydrochloride - ≥97%(HPLC) , CAS No.2320953-89-5

CAS: 2320953-89-5 Cat. No.: G286872 Molecular Weight: 453.41 PubChem CID: 124201849

GRADE & PURITY ≥97%(HPLC)

Synonyms

EPZ015866, GSK 3203591 | 2-(Cyclobutylamino)-N-[(2S)-3-(3,4-dihydro-2(1H)-isoquinolinyl)-2-hydropropyl]-4-pyridinecarboxamide dihydrochloride

Storage

Store at -20°C,Desiccated

Shipped In

Ice chest + Ice pads

Specifications

Synonyms

EPZ015866, GSK 3203591 | 2-(Cyclobutylamino)-N-[(2S)-3-(3, 4-dihydro-2(1H)-isoquinolinyl)-2-hydropropyl]-4-pyridinecarboxamide dihydrochloride

Specifications & Purity

≥97%(HPLC)

Biochemical and Physiological Mechanisms

Strong and selective PRMT5 inhibitor (IC50=4 nM). The selectivity to PRMT5 is higher than other PRMTs and lysine methyltransferases. It can inhibit the proliferation of mantle cell lymphoma (MCL) in vitro.

Storage

Store at -20°C, Desiccated

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Action Type

INHIBITOR

Purity

≥97%(HPLC)

Names and Identifiers

• Pubchem Sid: 504773001
• Pubchem Sid Url: https://pubchem.ncbi.nlm.nih.gov/substance/504773001
• Canonical Smiles: C1CC(C1)NC2=NC=CC(=C2)C(=O)NCC(CN3CCC4=CC=CC=C4C3)O.Cl.Cl
• IUPAC Name: 2-(cyclobutylamino)-N-[(2S)-3-(3,4-dihydro-1H-isoquinolin-2-yl)-2-hydroxypropyl]pyridine-4-carboxamide;dihydrochloride
• InChIKey: CDKUMVXFXBTOBE-FJSYBICCSA-N
• INCHI: 1S/C22H28N4O2.2ClH/c27-20(15-26-11-9-16-4-1-2-5-18(16)14-26)13-24-22(28)17-8-10-23-21(12-17)25-19-6-3-7-19;;/h1-2,4-5,8,10,12,19-20,27H,3,6-7,9,11,13-15H2,(H,23,25)(H,24,28);2*1H/t20-;;/m0../s1
• PubChem CID: 124201849
• Molecular Weight: 453.41

Chemical and Physical Properties

• Solubility: Solvent:water, Max Conc. mg/mL: 45.34, Max Conc. mM: 100; Solvent:DMSO, Max Conc. mg/mL: 45.34, Max Conc. mM: 100
• Sensitivity: Moisture sensitive