Hydroxylamine-O-sulfonic acid (HOSA) - ≥97% , CAS No.2950-43-8

CAS: 2950-43-8 Cat. No.: H100568 Molecular Weight: 113.09 EC Number: 220-971-6

GRADE & PURITY ≥97%

Synonyms

HOSA | aminooxysulfonic acid | MFCD00011604 | O-Hydroxylammonium sulfonate | AN-1317 | DTXSID50883542 | Hydroxylamine O-sulphonic acid | (Aminooxy)hydroxysulfane dioxide | BBL011058 | STK802234 | W-106985 | Calcium glucoheptone | HAOS | Hydroxylamine-O-su

Storage

Store at 2-8°C,Argon charged

Shipped In

Wet ice

Overview

Hydroxylamine-O-sulfonic acid (HOSA), an O-substituted hydroxylamine, is a widely used aminating agent. It can behave as a nucleophile as well as an electrophile. The conversion of organoboranes obtained from hydroboration of olefins to amines using HOSA has been reported.

Specifications

Synonyms

HOSA | aminooxysulfonic acid | MFCD00011604 | O-Hydroxylammonium sulfonate | AN-1317 | DTXSID50883542 | Hydroxylamine O-sulphonic acid | (Aminooxy)hydroxysulfane dioxide | BBL011058 | STK802234 | W-106985 | Calcium glucoheptone | HAOS | Hydroxylamine-O-su

Specifications & Purity

≥97%

Storage

Store at 2-8°C, Argon charged

Shipped In

Wet ice

This product requires cold chain shipping. Ground and other economy services are not available.

Purity

≥97%

Names and Identifiers

• Canonical Smiles: NOS(=O)(=O)O
• IUPAC Name: amino hydrogen sulfate
• InChIKey: DQPBABKTKYNPMH-UHFFFAOYSA-N
• INCHI: 1S/H3NO4S/c1-5-6(2,3)4/h1H2,(H,2,3,4)
• Isomeric SMILES: NOS(=O)(=O)O
• WGK Germany: 3
• RTECS: NC5427000
• UN Number: 3260
• Molecular Weight: 113.09
• Reaxy-Rn: 878303
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=878303&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Inorganic compounds
  • Superclass Homogeneous non-metal compounds
    • Class Non-metal oxoanionic compounds
      • Subclass Non-metal sulfates

• Kingdom: Inorganic compounds
• Superclass: Homogeneous non-metal compounds
• Class: Non-metal oxoanionic compounds
• Subclass: Non-metal sulfates
• Intermediate Tree Nodes: Not available
• Direct Parent: Non-metal sulfates
• Alternative Parents: Inorganic oxides
• Molecular Framework: Not available
• Substituents: Non-metal sulfate - Inorganic oxide
• Description: This compound belongs to the class of inorganic compounds known as non-metal sulfates. These are inorganic non-metallic compounds containing a sulfate as its largest oxoanion.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Chemical and Physical Properties

• Solubility: Soluble in water and methanol. Slightly soluble in ethanol. Insoluble in ether and chloroform.
• Sensitivity: Hygroscopic.
• Melt Point(°C): 208-201°C
• Molecular Weight: 113.100 g/mol
• XLogP3: -3.900
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 1
• Exact Mass: 112.978 Da
• Monoisotopic Mass: 112.978 Da
• Topological Polar Surface Area: 98.000 Ų
• Heavy Atom Count: 6
• Formal Charge: 0
• Complexity: 104.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1

References

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2. Fen Chen, Jingyuan Yu, Jintai Hu, Guoqing Zhang, Chunhui Du, Xuchun Li.  (2024)  Efficiency and mechanism of sludge thickening by a novel sandwich-like forward osmosis composite membrane constructed on microporous polyethylene separator.  CHEMICAL ENGINEERING JOURNAL,      [PMID:] [10.1016/j.cej.2024.158082]

3. Liyang Gong, Le Chang, Siyu Chen, Xuan Wei, Huiping Du, Jiamin Cheng, Xiaoxuan Chen, Zhang Yuan, Pan Zhao, Meijuan Geng, Hui Yang, Kaiyong Cai, Liangliang Dai.  (2025)  Multifunctional injectable hydrogel with self-supplied H2S release and bacterial inhibition for the wound healing with enhanced macrophages polarization via interfering with PI3K/Akt pathway.  BIOMATERIALS,      [PMID:39892016] [10.1016/j.biomaterials.2025.123144]

4. Xiangyu Wen, Qiusheng Yang, Ming Li, Xiaoshu Ding, Peng Zhai, Yao Lu, Xinqiang Zhao, Yanji Wang, Dongsheng Zhang.  (2025)  Two-step synthesis of amino-methyl-N-phenylcarbamate from toluidine: New preparative method and mechanism.  Reaction Chemistry & Engineering,      [PMID:] [10.1039/D5RE00246J]