L-(+)-α-Phenylglycine - ≥98% , CAS No.2935-35-5

CAS: 2935-35-5 Cat. No.: P109236 Molecular Weight: 151.16 Beilstein Registry Number: 2208675 EC Number: 220-909-8

GRADE & PURITY ≥98%

Synonyms

L-(+)-a-Phenylglycine | Q27225746 | (S)-.ALPHA.-AMINOBENZENEACETIC ACID | .ALPHA.-PHENYLGLYCINE S-FORM | L-(+)- | MFCD09266182 | AS-14724 | L-(+)-alpha-Phenylglycine, 99% | W-104013 | (2S)-amino(phenyl)acetic acid | AKOS015923207 | (6-Oxo-1,6-dihydropyrid

Storage

Room temperature

Shipped In

Normal

Specifications

Synonyms

L-(+)-a-Phenylglycine | Q27225746 | (S)-.ALPHA.-AMINOBENZENEACETIC ACID | .ALPHA.-PHENYLGLYCINE S-FORM | L-(+)- | MFCD09266182 | AS-14724 | L-(+)-alpha-Phenylglycine, 99% | W-104013 | (2S)-amino(phenyl)acetic acid | AKOS015923207 | (6-Oxo-1, 6-dihydropyrid

Specifications & Purity

≥98%

Storage

Room temperature

Shipped In

Normal

Purity

≥98%

Names and Identifiers

• Pubchem Sid: 488187173
• Pubchem Sid Url: https://pubchem.ncbi.nlm.nih.gov/substance/488187173
• Canonical Smiles: C1=CC=C(C=C1)C(C(=O)O)N
• IUPAC Name: (2S)-2-amino-2-phenylacetic acid
• InChIKey: ZGUNAGUHMKGQNY-ZETCQYMHSA-N
• INCHI: 1S/C8H9NO2/c9-7(8(10)11)6-4-2-1-3-5-6/h1-5,7H,9H2,(H,10,11)/t7-/m0/s1
• Isomeric SMILES: C1=CC=C(C=C1)[C@@H](C(=O)O)N
• WGK Germany: 3
• Molecular Weight: 151.16
• Beilstein: 2208675
• Reaxy-Rn: 608018
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=608018&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organic acids and derivatives
    • Class Carboxylic acids and derivatives
      • Subclass Amino acids, peptides, and analogues
        • Level5 Amino acids and derivatives
          • Level6 Alpha amino acids and derivatives
            • Level7 Alpha amino acids
              • Level8 L-alpha-amino acids

• Kingdom: Organic compounds
• Superclass: Organic acids and derivatives
• Class: Carboxylic acids and derivatives
• Subclass: Amino acids, peptides, and analogues
• Intermediate Tree Nodes: Amino acids and derivatives - Alpha amino acids and derivatives - Alpha amino acids
• Direct Parent: L-alpha-amino acids
• Alternative Parents: Aralkylamines Benzene and substituted derivatives Amino acids Monocarboxylic acids and derivatives Carboxylic acids Organopnictogen compounds Organic oxides Monoalkylamines Hydrocarbon derivatives Carbonyl compounds
• Molecular Framework: Aromatic homomonocyclic compounds
• Substituents: L-alpha-amino acid - Aralkylamine - Monocyclic benzene moiety - Benzenoid - Amino acid - Carboxylic acid - Monocarboxylic acid or derivatives - Amine - Hydrocarbon derivative - Organic oxide - Primary amine - Organooxygen compound - Organonitrogen compound - Organopnictogen compound - Primary aliphatic amine - Organic oxygen compound - Carbonyl group - Organic nitrogen compound - Aromatic homomonocyclic compound
• Description: This compound belongs to the class of organic compounds known as l-alpha-amino acids. These are alpha amino acids which have the L-configuration of the alpha-carbon atom.
• External Descriptors: alpha-phenylglycine

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Associated Targets(Human)

CACNA2D1 Tclin Voltage-gated calcium channel alpha2/delta subunit 1 (266 Activities)

Discover Target: CACNA2D1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

SLC1A4 Tbio Neutral amino acid transporter A (18 Activities)

Discover Target: SLC1A4

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

SLC1A5 Tchem Neutral amino acid transporter B(0) (65 Activities)

Discover Target: SLC1A5

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

Rattus norvegicus (775804 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Grin1 Glutamate NMDA receptor (6467 Activities)

Discover Target: Grin1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Slc1a5 Amino acid transporter (271 Activities)

Discover Target: Slc1a5

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Chemical and Physical Properties

• Specific Rotation[α]: 158 ° (C=1, 1mol/L HCl)
• Melt Point(°C): 300°C
• Molecular Weight: 151.160 g/mol
• XLogP3: -1.700
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 151.063 Da
• Monoisotopic Mass: 151.063 Da
• Topological Polar Surface Area: 63.300 Ų
• Heavy Atom Count: 11
• Formal Charge: 0
• Complexity: 141.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 1
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1

References

1. Li Yuchen, Xu Guangfu, Chen Jiaquan, Yu Tao, Miao Pandeng, Du Yingxiang.  (2023)  One-step synthesis of chiral molecularly imprinted polymer TiO2 nanoparticles for enantioseparation of phenylalanine in coated capillary electrochromatography.  MICROCHIMICA ACTA,  190  (7): (1-11).  [PMID:37391671] [10.1007/s00604-023-05854-4]

2. Xi-Meng Li, Bei-Ni Chen, Zheng-Quan Nie, Jian-Mei Yang, Jun-Nan He, Tong Yang, Jun-Hui Zhang, Jin-Xin Yang, Lei Zhang, Yan Zhao, Yue Sun, Jin Zhang.  (2025)  A chiral electrochemical sensor for detecting the enantiomeric ratio of mandelic acid and studying the enantioselective mechanism.  MICROCHEMICAL JOURNAL,      [PMID:] [10.1016/j.microc.2025.115840]