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| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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10mM in DMSO for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Store at -80°C Ships Dry ice packs + Cold packs Check lot-specific COA for exact specifications.
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
LY3154207 is a potent, subtype selective, and orally available human dopamine D1 receptor positive allosteric modulator (PAM) with minimal allosteric agonist activity ( EC 50 =3 nM)
In Vitro
In HEK293 cells transiently expressing human, dog, rhesus monkey, and mouse D1 receptors, the EC 50 s of LY3154207 are 2.3 nM, 2.0 nM, 2.5 nM, and 62.1 nM, respectively. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
IC50& Target:EC50: 3 nM (human dopamine D1 receptor)
| ALogP | 4.4 |
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| Isomeric SMILES | C[C@H]1C2=CC=CC(=C2C[C@@H](N1C(=O)CC3=C(C=CC=C3Cl)Cl)CO)CCC(C)(C)O |
|---|---|
| Alternate CAS | 1638667-79-4 |
| PubChem CID | 86290953 |
| MeSH Entry Terms | 2-(2,6-Dichlorophenyl)-1-((1 S,3 R)-5-(3-hydroxy-3-methylbutyl)-3-(hydroxymethyl)-1-methyl-3,4-dihydroisoquinolin-2(1H)-yl)ethan-1-one;LY3154207;Mevidalen |
| Molecular Weight | 450.40 |
Comprehensive hazard, handling, storage, and regulatory compliance document.
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