M 30 dihydrochloride - ≥98%(HPLC) , CAS No.64821-19-8

CAS: 64821-19-8 Cat. No.: M286539 Molecular Weight: 299.2 EC Number: 694-386-3 PubChem CID: 71311622

GRADE & PURITY ≥98%(HPLC)

Synonyms

5-[[methyl(prop-2-ynyl)amino]methyl]quinolin-8-ol;dihydrochloride | 5-{[Methyl(prop-2-yn-1-yl)amino]methyl}quinolin-8-ol--hydrogen chloride (1/2) | DTXSID10746624 | M 30 dihydrochloride | MAO-IN-M30 dihydrochloride | MS-24301 | MAO-IN-M30 (dihydrochloride

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Overview

Product Describtion:

MAO-IN-M30 dihydrochloride is an orally active, brain-permeable, and brain selective irreversible MAO-A (IC50=37 nM) and MAO-B (IC50=57 nM) inhibitor. MAO-IN-M30 dihydrochloride is a potent iron chelator and radical scavenger. MAO-IN-M30 dihydrochloride has a neuroprotective effect against Dexamethasone-induced brain cell apoptosis. MAO-IN-M30 dihydrochloride also exhibits neurorestorative activity in post MPTP and lactacystin models of Parkinson's disease.

Specifications

Synonyms

5-[[methyl(prop-2-ynyl)amino]methyl]quinolin-8-ol;dihydrochloride | 5-{[Methyl(prop-2-yn-1-yl)amino]methyl}quinolin-8-ol--hydrogen chloride (1/2) | DTXSID10746624 | M 30 dihydrochloride | MAO-IN-M30 dihydrochloride | MS-24301 | MAO-IN-M30 (dihydrochloride

Specifications & Purity

≥98%(HPLC)

Biochemical and Physiological Mechanisms

Potent and brain selective monoamine oxidase (MAO) inhibitor (EC50values are 37 and 57 nM for MAO-A and MAO-B, respectively). Also an iron chelator with antioxidant properties. Protects cells against6-OHDA induced apoptosis. Attenuates MPTP depletion of D

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Action Type

INHIBITOR

Purity

≥98%(HPLC)

Names and Identifiers

• Canonical Smiles: CN(CC#C)CC1=C2C=CC=NC2=C(C=C1)O.Cl.Cl
• IUPAC Name: 5-[[methyl(prop-2-ynyl)amino]methyl]quinolin-8-ol;dihydrochloride
• InChIKey: XJNICPXVRPOSSO-UHFFFAOYSA-N
• INCHI: 1S/C14H14N2O.2ClH/c1-3-9-16(2)10-11-6-7-13(17)14-12(11)5-4-8-15-14;;/h1,4-8,17H,9-10H2,2H3;2*1H
• Isomeric SMILES: CN(CC#C)CC1=C2C=CC=NC2=C(C=C1)O.Cl.Cl
• WGK Germany: 3
• PubChem CID: 71311622
• Molecular Weight: 299.2

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organoheterocyclic compounds
    • Class Quinolines and derivatives
      • Subclass 8-hydroxyquinolines

• Kingdom: Organic compounds
• Superclass: Organoheterocyclic compounds
• Class: Quinolines and derivatives
• Subclass: 8-hydroxyquinolines
• Intermediate Tree Nodes: Not available
• Direct Parent: 8-hydroxyquinolines
• Alternative Parents: Aralkylamines 1-hydroxy-2-unsubstituted benzenoids Pyridines and derivatives Heteroaromatic compounds Trialkylamines Azacyclic compounds Acetylides Organooxygen compounds Hydrochlorides Hydrocarbon derivatives
• Molecular Framework: Aromatic heteropolycyclic compounds
• Substituents: 8-hydroxyquinoline - Phenol - Aralkylamine - 1-hydroxy-2-unsubstituted benzenoid - Benzenoid - Pyridine - Heteroaromatic compound - Tertiary aliphatic amine - Tertiary amine - Azacycle - Acetylide - Hydrocarbon derivative - Organic nitrogen compound - Hydrochloride - Amine - Organooxygen compound - Organic oxygen compound - Organonitrogen compound - Aromatic heteropolycyclic compound
• Description: This compound belongs to the class of organic compounds known as 8-hydroxyquinolines. These are compounds containing a quinoline moiety, which carries a hydroxy group at the 8-position. Quinoline consists of a benzene ring fused to a pyrimidine ring to form benzo[b]azabenzene.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Chemical and Physical Properties

• Solubility: Solvent:water, Max Conc. mg/mL: 29.92, Max Conc. mM: 100
• Sensitivity: Moisture sensitive.
• Molecular Weight: 299.200 g/mol
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 298.064 Da
• Monoisotopic Mass: 298.064 Da
• Topological Polar Surface Area: 36.400 Ų
• Heavy Atom Count: 19
• Formal Charge: 0
• Complexity: 296.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 3

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