Determine the necessary mass, volume, or concentration for preparing a solution.
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
Moligand™,≥95% Moligand™ for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Store at 2-8°C Ships Wet ice Check lot-specific COA for exact specifications.
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Cited in 16 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Product Description:
Mangiferin (MGF) is a natural bioactive polyphenol predominantly isolated from the Mangifera indica (Mango) tree. It has a xanthone glucoside structure. Mangiferin can also be found in other angiosperm plants and herbs.
Product Application:
Mangiferin has been used:
as a reference standard for the characterization of mangiferin from Mangifera indica using ultrasound with three-phase partitioning (UTPP)
to study its effects in promoting brown adipose phenotype murine C3H10T1/2 mesenchymal stem cells (MSCs) and its role in mitochondrial biogenesis and homeostasis
as a reference standard for the quantitative determination of markers compounds in the culture Swertia paniculata shoot culture using high-performance thin-layer chromatography.
| Pubchem Sid | 504763370 |
|---|---|
| Pubchem Sid Url | https://pubchem.ncbi.nlm.nih.gov/substance/504763370 |
| Canonical Smiles | C1=C2C(=CC(=C1O)O)OC3=C(C2=O)C(=C(C(=C3)O)C4C(C(C(C(O4)CO)O)O)O)O |
| IUPAC Name | 1,3,6,7-tetrahydroxy-2-[(2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]xanthen-9-one |
| InChIKey | AEDDIBAIWPIIBD-ZJKJAXBQSA-N |
| INCHI | 1S/C19H18O11/c20-4-11-15(25)17(27)18(28)19(30-11)12-8(23)3-10-13(16(12)26)14(24)5-1-6(21)7(22)2-9(5)29-10/h1-3,11,15,17-23,25-28H,4H2/t11-,15-,17+,18-,19+/m1/s1 |
| Isomeric SMILES | C1=C2C(=CC(=C1O)O)OC3=C(C2=O)C(=C(C(=C3)O)[C@H]4[C@@H]([C@H]([C@@H]([C@H](O4)CO)O)O)O)O |
| Molecular Weight | 422.34 |
| Reaxy-Rn | 1359328 |
| Reaxys-RN_link_address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=1359328&ln= |
Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS →Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA →Full quality attributes and acceptance criteria for this grade.
View spec sheet →Taxonomy Tree
| Kingdom | Organic compounds |
|---|---|
| Superclass | Organoheterocyclic compounds |
| Class | Benzopyrans |
| Subclass | 1-benzopyrans |
| Intermediate Tree Nodes | Dibenzopyrans - Xanthenes |
| Direct Parent | Xanthones |
| Alternative Parents | Phenolic glycosides Hexoses C-glycosyl compounds Chromones Pyranones and derivatives 1-hydroxy-2-unsubstituted benzenoids 1-hydroxy-4-unsubstituted benzenoids Oxanes Vinylogous acids Heteroaromatic compounds Secondary alcohols Polyols Oxacyclic compounds Dialkyl ethers Organic oxides Primary alcohols Hydrocarbon derivatives |
| Molecular Framework | Aromatic heteropolycyclic compounds |
| Substituents | Phenolic glycoside - Xanthone - Hexose monosaccharide - C-glycosyl compound - Chromone - Glycosyl compound - 1-hydroxy-4-unsubstituted benzenoid - 1-hydroxy-2-unsubstituted benzenoid - Pyranone - Benzenoid - Pyran - Oxane - Monosaccharide - Heteroaromatic compound - Vinylogous acid - Secondary alcohol - Oxacycle - Polyol - Dialkyl ether - Ether - Hydrocarbon derivative - Organic oxygen compound - Organic oxide - Organooxygen compound - Primary alcohol - Alcohol - Aromatic heteropolycyclic compound |
| Description | This compound belongs to the class of organic compounds known as xanthones. These are polycyclic aromatic compounds containing a xanthene moiety conjugated to a ketone group at carbon 9. Xanthene is a tricyclic compound made up of two benzene rings linearly fused to each other through a pyran ring. |
| External Descriptors | xanthenes |
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
Find and download the COA for your product by matching the lot number on the packaging.
| Lot Number | Certificate Type | Date | Item |
|---|---|---|---|
| Certificate of Analysis | Nov 13, 2025 | M196329 | |
| Certificate of Analysis | Nov 13, 2025 | M196329 | |
| Certificate of Analysis | Nov 13, 2025 | M196329 | |
| Certificate of Analysis | Nov 13, 2025 | M196329 | |
| Certificate of Analysis | Nov 13, 2025 | M196329 | |
| Certificate of Analysis | Nov 13, 2025 | M196329 | |
| Certificate of Analysis | Aug 11, 2025 | M196329 | |
| Certificate of Analysis | Aug 03, 2024 | M196329 | |
| Certificate of Analysis | Aug 03, 2024 | M196329 | |
| Certificate of Analysis | Aug 03, 2024 | M196329 | |
| Certificate of Analysis | Aug 03, 2024 | M196329 | |
| Certificate of Analysis | Aug 03, 2024 | M196329 | |
| Certificate of Analysis | Aug 03, 2024 | M196329 | |
| Certificate of Analysis | Aug 03, 2024 | M196329 | |
| Certificate of Analysis | Feb 26, 2024 | M196329 | |
| Certificate of Analysis | Feb 26, 2024 | M196329 | |
| Certificate of Analysis | Feb 26, 2024 | M196329 | |
| Certificate of Analysis | Feb 26, 2024 | M196329 | |
| Certificate of Analysis | Feb 26, 2024 | M196329 | |
| Certificate of Analysis | Feb 26, 2024 | M196329 | |
| Certificate of Analysis | Jun 21, 2023 | M196329 | |
| Certificate of Analysis | Sep 06, 2021 | M196329 |
| Sensitivity | Heat Sensitive |
|---|---|
| Melt Point(°C) | 270 °C |
| Molecular Weight | 422.300 g/mol |
| XLogP3 | -0.400 |
| Hydrogen Bond Donor Count | 8 |
| Hydrogen Bond Acceptor Count | 11 |
| Rotatable Bond Count | 2 |
| Exact Mass | 422.085 Da |
| Monoisotopic Mass | 422.085 Da |
| Topological Polar Surface Area | 197.000 Ų |
| Heavy Atom Count | 30 |
| Formal Charge | 0 |
| Complexity | 646.000 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 5 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| The total count of all stereochemical bonds | 0 |
| Covalently-Bonded Unit Count | 1 |
| 1. Wanran Huang, Yanni Wang, Wei Huang. (2023) Mangiferin alleviates 6-OHDA-induced Parkinson's disease by inhibiting AKR1C3 to activate Wnt signaling pathway. NEUROSCIENCE LETTERS, [PMID:38142926] [10.1016/j.neulet.2023.137608] |
| 2. Hang Zhou, Zhang Mao, Xiaonan Zhang, Ruomiao Li, Jian Yin, Yinghui Xu. (2023) Neuroprotective Effect of Mangiferin against Parkinson’s Disease through G-Protein-Coupled Receptor-Interacting Protein 1 (GIT1)-Mediated Antioxidant Defense. ACS Chemical Neuroscience, [PMID:37036451] [10.1021/acschemneuro.2c00458] |
| 3. Yuhang Xing, Ruyi Li, Lu Xue, Mianhong Chen, Xuli Lu, Zhihao Duan, Wei Zhou, Jihua Li. (2022) Double emulsion (W/O/W) gel stabilised by polyglycerol polyricinoleate and calcium caseinate as mangiferin carrier: insights on formulation and stability properties. INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY, 57 (8): (5268-5279). [PMID:] [10.1111/ijfs.15856] |
| 4. Ye Wu, Yu Wang, Linyu Long, Cheng Hu, Qingquan Kong, Yunbing Wang. (2021) A spatiotemporal release platform based on pH/ROS stimuli-responsive hydrogel in wound repairing. JOURNAL OF CONTROLLED RELEASE, [PMID:34813880] [10.1016/j.jconrel.2021.11.027] |
| 5. Yunbo Li, Benguo Liu, Mengmeng Yu, Sheng Geng. (2021) High-efficiency formation mechanism of mangiferin/γ-cyclodextrin complex. FOOD SCIENCE AND TECHNOLOGY RESEARCH, [PMID:] [10.3136/fstr.27.735] |
| 6. Chao Yin, Jun Zheng, Yufan Yang, Xianwen Song, Miao Cui, Rujuan Shen, Yi Zhang. (2025) A facile preparation strategy for multifunctional hydrogel films with adjustable performance in food preservation. Food Packaging and Shelf Life, [PMID:] [10.1016/j.fpsl.2025.101471] |
| 7. Mengke Hao, Simin Wei, Siqi Su, Zhishu Tang, Yinghui Wang. (2024) A Multifunctional Hydrogel Fabricated by Direct Self-Assembly of Natural Herbal Small Molecule Mangiferin for Treating Diabetic Wounds. ACS Applied Materials & Interfaces, [PMID:38709623] [10.1021/acsami.4c01265] |
| 8. Yanhong Bi, Ruiping Fu, Weiliang Hua, Xinyu Xiong, Chun Zhu, Xiaobao Nie, Zhaoyu Wang. (2025) An empirical exploration of the capacity of choline chloride/lactic acid eutectics to extract and stabilize natural polyhydroxy compounds. FOOD CHEMISTRY, [PMID:40120314] [10.1016/j.foodchem.2025.143873] |
| 9. Huilin Deng, Yaozhong Zheng, Qiongyao Wang, Jiaqi Peng, Weibin Bai, Lingmin Tian, Zouyan He, Rui Jiao. (2025) In vitro gastrointestinal digestion and colonic fermentation of Mangiferin: Impacts on gut microbiota and metabolite profiles. Journal of Functional Foods, [PMID:] [10.1016/j.jff.2025.106667] |
| 10. Cheng Lu, ShiJun Deng, YanJiao Liu, ShengJin Yang, DingMei Qin, LiJuan Zhang, Rui-rui Wang, Yi Zhang. (2024) Inhibition of macrophage MAPK/NF-κB pathway and Th2 axis by mangiferin ameliorates MC903-induced atopic dermatitis. INTERNATIONAL IMMUNOPHARMACOLOGY, [PMID:38621336] [10.1016/j.intimp.2024.112038] |
| 11. Siyi Wang, Min Nian, Yu Ma, Xiaojia Chen, Xiaotong Ji, Changzhi Shi, Xing Chen, Mingliang Fang. (2025) Machine Learning-Based Screening of Cosmetic Ingredients Identifies Vat Blue 6 as a Thyroid Hormone Receptor β Disruptor. ENVIRONMENTAL SCIENCE & TECHNOLOGY, [PMID:40668138] [10.1021/acs.est.5c04327] |
| 12. Wei Nong, Xiaoli Chen, Yixin Chen, Xueping Feng, Wen Kong, Rui Chi, Li Yan, Zhiquan Wei. (2025) Natural polyphenol mangiferin delays neuronal cell senescence by inhibiting neuroinflammation mediated by microglial activation. IBRO Neuroscience Reports, [PMID:40271493] [10.1016/j.ibneur.2025.04.006] |
| 13. Shuang Wang, Yuan Qin, Yashi Liu, Rui Jiao, Rui Lin, Zongxiang Yuan, Zouyan He. (2025) Lipid-lowering effect of mangiferin through the inhibition of pancreatic lipase activity. JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE, [PMID:40265679] [10.1002/jsfa.14301] |
| 14. Zhifeng Cai, Tianyu Miao, Guiyu Meng, Yanan Li. (2025) N, S-CDs for colorimetric/fluorometric dual-mode nanosensor and smartphone-based determination of curcumin in fruits. FOOD CONTROL, [PMID:] [10.1016/j.foodcont.2025.111515] |
| 15. Ruoying Du, Xiaoyun Jiang, Yichen Wang, Jin Wang, Bo Si, Chun Chang, Yonglin Lu, Lishuang Lv. (2026) Scavenging multiple reactive carbonyl species simultaneously by mangiferin and its aglycone norathyriol in vitro and in vivo. FOOD RESEARCH INTERNATIONAL, [PMID:41794501] [10.1016/j.foodres.2026.118639] |
| 16. Zhifeng Cai, Lingjie Hou, Qun Cai, Yaxuan Feng, Yiran Zhang, Yuqi Zhang. (2026) Determination of mangiferin via a smartphone-assisted fluorescence system with blue-emitting carbon quantum dots. COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS, [PMID:] [10.1016/j.colsurfa.2026.139930] |
Our grade selection guide covers purity, stabilizer status, and application suitability for all variants in our catalog.
View Moligand™ grade guide →