10mM in DMSO for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Store at -80°C Ships Dry ice packs + Cold packs Check lot-specific COA for exact specifications.
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Cited in 3 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Information
Nitazoxanide (NTZ, NSC 697855) is a synthetic nitrothiazolyl-salicylamide derivative and an antiprotozoal agent(IC50 for canine influenza virus ranges from 0.17 to 0.21 μM). Nitazoxanide modulatesautophagyand inhibitsmTORC1signaling.
In vitro
Nitazoxanide reduces parasite growth in cell culture by more than 90% with little evidence of drug-associated cytotoxicity. Nitazoxanide is a new thiazolide antiparasitic agent that shows excellent in vitro activity against a wide variety of protozoa and helminths. Nitazoxanide and its metabolite tizoxanide are more active in vitro than metronidazole against G. intestinalis, E. histolytica and T. vaginalis. Nitazoxanide exhibits potent inhibition of both HBV and HCV replication. Nitazoxanide potentiates the effect of subsequent treatment with Nitazoxanide plus IFN, but not Nitazoxanide plus 2\'CmeC, in HCV replicon-containing cells. Nitazoxanide induces reductions in several HBV proteins (HBsAg, HBeAg, HBcAg) produced by 2.2.15 cells, but does not affect HBV RNA transcription. Nitazoxanide exhibits IC50, and IC90 values of 0.017 and 0.776 mg/mL respectively, against E. histolytica, 0.004 and 0.067 mg/mL against G. intestinalis, and 0.034 and 2.046 mg/mL against T. vaginalis. Nitazoxanide is more toxic than metronidazole and albendazole against E. histolytica.
In vivo
Nitazoxanide is partially effective at reducing the parasite burden in a gnotobiotic piglet diarrhea model when given orally for 11 days at 250 mg/kg/day but not at 125 mg/kg/day. Nitazoxanide induces a drug-related diarrhea in piglets that might have influenced its therapeutic efficacy.
Cell Data
cell lines：
Concentrations：
Incubation Time：
Powder Purity:≥99%
| ALogP | 2 |
|---|
| Isomeric SMILES | CC(=O)OC1=CC=CC=C1C(=O)NC2=NC=C(S2)[N+](=O)[O-] |
|---|---|
| WGK Germany | 3 |
| Molecular Weight | 307.28 |
| Reaxy-Rn | 1225475 |
| Reaxys-RN_link_address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=1225475&ln= |
Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS →Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA →Full quality attributes and acceptance criteria for this grade.
View spec sheet →| Solubility | Solubility (25°C) In vitro DMSO: 57 mg/mL (201.17 mM); Ethanol: 4 mg/mL (14.11 mM); Water: Insoluble; |
|---|---|
| Melt Point(°C) | 198.0 - 202.0 °C |
| 1. Zhanding Cui, Dengliang Li, Yinli Xie, Kai Wang, Ying Zhang, Guohua Li, Qian Zhang, Xiaoxueying Chen, Yue Teng, Shihui Zhao, Jiang Shao, Fan Xingmeng, Yanli Zhao, Dongju Du, Yanbing Guo, Hailong Huang, Hao Dong, Guixue Hu, Shuang Zhang, Yongkun Zhao. (2020) Nitazoxanide protects cats from feline calicivirus infection and acts synergistically with mizoribine in vitro. ANTIVIRAL RESEARCH, [PMID:32579897] [10.1016/j.antiviral.2020.104827] |
| 2. Cui Zhanding, Liu Jinlong, Xie Chong, Wang Tao, Sun Pu, Wang Jinlong, Li Jiaoyang, Li Guoxiu, Qiu Jicheng, Zhang Ying, Li Dengliang, Sun Ying, Yin Juanbin, Li Kun, Zhao Zhixun, Yuan Hong, Bai Xingwen, Ma Xueqing, Li Pinghua, Fu Yuanfang, Bao Huifang, Li Dong, Zhang Qiang, Liu Zaixin, Cao Yimei, Zhang Jing, Lu Zengjun. (2024) High-throughput screening unveils nitazoxanide as a potent PRRSV inhibitor by targeting NMRAL1. Nature Communications, 15 (1): (1-12). [PMID:38844461] [10.1038/s41467-024-48807-y] |
| 3. Xianzhe Wang, Yanyan Zhu, Huilin Liu, Xiangchuan Wang, Hongjie Zhang, Xiuping Chen. (2024) Nitazoxanide alleviates experimental pulmonary fibrosis by inhibiting the development of cellular senescence. LIFE SCIENCES, [PMID:39662775] [10.1016/j.lfs.2024.123302] |
