NVP-BVU972 - ≥98% , CAS No.1185763-69-2

CAS: 1185763-69-2 Cat. No.: N128061 Formule: C₂₀H₁₆N₆ Poids moléculaire: 340.38

GRADE & PURITY ≥98%

Synonyms

NCGC00346689-02 | (.+/-.)-2-Ethyloxirane | Allylglycide ether | BDBM50146169 | MLS006010964 | AS-56284 | C71592 | RNCNPRCUHHDYPC-UHFFFAOYSA-N | 3qti | Alyl chloride oxide | NCGC00346689-01 | BCP03600 | 1185763-69-2 | 6-{[6-(1-Methyl-1h-Pyrazol-4-Yl)imidaz

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Vue d’ensemble

NVP-BVU972 is a selective and potent Met inhibitor with IC50 of 14 nM.
A selective and potent Met inhibitor (IC50 = 14 nM)

Specifications

Synonymes

NCGC00346689-02 | (.+/-.)-2-Ethyloxirane | Allylglycide ether | BDBM50146169 | MLS006010964 | AS-56284 | C71592 | RNCNPRCUHHDYPC-UHFFFAOYSA-N | 3qti | Alyl chloride oxide | NCGC00346689-01 | BCP03600 | 1185763-69-2 | 6-{[6-(1-Methyl-1h-Pyrazol-4-Yl)imidaz

Spécifications et pureté

≥98%

Mécanismes biochimiques et physiologiques

NVP-BVU972 is a selective and potent Met inhibitor (IC50 = 14 nM). Antitumor agents.

Conditions de stockage de stockage

Store at -20°C

Expédié en

Ice chest + Ice pads

Ce produit nécessite l'expédition en chaîne froide. Les services terrestres et autres services économiques ne sont pas disponibles.

Type d'action

INHIBITOR

Pureté

≥98%

Noms et identifiants

Pubchem Sid

504770312

Pubchem Sid Url

https://pubchem.ncbi.nlm.nih.gov/substance/504770312

Sourires canoniques

CN1C=C(C=N1)C2=NN3C(=NC=C3CC4=CC5=C(C=C4)N=CC=C5)C=C2

IUPAC Name

6-[[6-(1-methylpyrazol-4-yl)imidazo[1,2-b]pyridazin-3-yl]methyl]quinoline

InChIKey

RNCNPRCUHHDYPC-UHFFFAOYSA-N

INCHI

1S/C20H16N6/c1-25-13-16(11-23-25)19-6-7-20-22-12-17(26(20)24-19)10-14-4-5-18-15(9-14)3-2-8-21-18/h2-9,11-13H,10H2,1H3

Isomères SMILES

CN1C=C(C=N1)C2=NN3C(=NC=C3CC4=CC5=C(C=C4)N=CC=C5)C=C2

Poids moléculaire

340.38

Reaxy-Rn

19770146

Reaxys-RN_link_address

https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=19770146&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organoheterocyclic compounds
    • Classe Quinolines and derivatives

• Kingdom: Organic compounds
• Superclass: Organoheterocyclic compounds
• Classe: Quinolines and derivatives
• Subclass: Not available
• Intermediate Tree Nodes: Not available
• Direct Parent: Quinolines and derivatives
• Alternative Parents: Pyridines and derivatives Pyridazines and derivatives N-substituted imidazoles Benzenoids Pyrazoles Heteroaromatic compounds Azacyclic compounds Organonitrogen compounds Hydrocarbon derivatives
• Molecular Framework: Aromatic heteropolycyclic compounds
• Substituents: Quinoline - Benzenoid - Pyridine - Pyridazine - N-substituted imidazole - Heteroaromatic compound - Pyrazole - Imidazole - Azole - Azacycle - Organic nitrogen compound - Hydrocarbon derivative - Organonitrogen compound - Aromatic heteropolycyclic compound
• Description: This compound belongs to the class of organic compounds known as quinolines and derivatives. These are compounds containing a quinoline moiety, which consists of a benzene ring fused to a pyrimidine ring to form benzo[b]azabenzene.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Cibles associées (humaines)

MET Tclin Hepatocyte growth factor receptor (1 Activities)

Discover Target: MET

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

MET Tclin Hepatocyte growth factor receptor (10718 Activities)

Discover Target: MET

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

AOX1 Tchem Aldehyde oxidase (429 Activities)

Discover Target: AOX1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Cibles associées (non humaines)

Hdac6 Histone deacetylase 6 (222 Activities)

Discover Target: Hdac6

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

rep Replicase polyprotein 1ab (378 Activities)

Discover Target: rep

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mécanismes d'action

Propriétés chimiques et physiques

• Solubilité: DMSO 68 mg/mL Water <1 mg/mL Ethanol 68 mg/mL
• Poids moléculaire: 340.400 g/mol
• XLogP3: 2.500
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 3
• Exact Mass: 340.144 Da
• Monoisotopic Mass: 340.144 Da
• Topological Polar Surface Area: 60.900 Ų
• Heavy Atom Count: 26
• Formal Charge: 0
• Complexity: 487.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1

Foire aux questions

What is the purity of this product?

This product is supplied at ≥98% purity (chemical assay). Lot-specific values are stated on the Certificate of Analysis.

How should this product be stored?

Store at ?20 °C. Freezer storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships in an insulated container with ice pads. Unpack on arrival and transfer it to the storage condition stated above.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 1185763-69-2, the molecular formula is C20H16N6, and the molecular weight is 340.38 g/mol. InChIKey RNCNPRCUHHDYPC-UHFFFAOYSA-N.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.