Palmatine chloride is irreversible indoleamine 2,3-dioxygenase 1 (IDO-1) inhibitor with IC50s of 3 μM and 157μM against HEK 293-hIDO-1 and rhIDO-1, respectively. Palmatine chloride can also inhibit West Nile virus (WNV) NS2B-NS3 protease in an uncompetitive manner with an IC50 of 96 μM. Palmatine chloride shows anti-cancer, anti-oxidation, anti-inflammatory, neuroprotection, antibacterial, anti-viral activities.

Specifications

Synonyms

Specifications & Purity

Moligand™, ≥98%

Biochemical and Physiological Mechanisms

Protoberberine alkaloid. AChE inhibitor (IC 50 = 7 μM). Central monoamine modulator. Shows antioxidant effects. Decreases central catecholamine activity. Decreases dopamine and increases 5-HT concentration in the brain. Shows antiarrhythmic, analgesic and

Source

Synthetic

Storage

Store at -20°C, Argon charged, Desiccated

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Grade

Moligand™

Action Type

INHIBITOR

Note

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Purity

≥98%

Names and Identifiers

Pubchem Sid	488184781
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/488184781
Canonical Smiles	COC1=C(C2=C[N+]3=C(C=C2C=C1)C4=CC(=C(C=C4CC3)OC)OC)OC.[Cl-]
IUPAC Name	2,3,9,10-tetramethoxy-5,6-dihydroisoquinolino[2,1-b]isoquinolin-7-ium;chloride
InChIKey	RLQYRXCUPVKSAW-UHFFFAOYSA-M
INCHI	1S/C21H22NO4.ClH/c1-23-18-6-5-13-9-17-15-11-20(25-3)19(24-2)10-14(15)7-8-22(17)12-16(13)21(18)26-4;/h5-6,9-12H,7-8H2,1-4H3;1H/q+1;/p-1
Isomeric SMILES	COC1=C(C2=C[N+]3=C(C=C2C=C1)C4=CC(=C(C=C4CC3)OC)OC)OC.[Cl-]
PubChem CID	73442
Molecular Weight	387.86

Documentation

📋 Safety Data Sheet (SDS)

Comprehensive hazard, handling, storage, and regulatory compliance document.

Download SDS →

✅ Certificate of Analysis (COA)

Lot-specific quality data. Enter your lot number to retrieve the exact COA.

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📊 Datasheet

Quick-reference summary of product specifications and applications.

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🔬 Specification Sheet

Full quality attributes and acceptance criteria for this grade.

View spec sheet →

Advanced Data

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Alkaloids and derivatives
  - Class Protoberberine alkaloids and derivatives

Kingdom	Organic compounds
Superclass	Alkaloids and derivatives
Class	Protoberberine alkaloids and derivatives
Subclass	Not available
Intermediate Tree Nodes	Not available
Direct Parent	Protoberberine alkaloids and derivatives
Alternative Parents	Isoquinolines and derivatives Anisoles Alkyl aryl ethers Pyridinium derivatives Heteroaromatic compounds Azacyclic compounds Organopnictogen compounds Organonitrogen compounds Organic chloride salts Hydrocarbon derivatives
Molecular Framework	Aromatic heteropolycyclic compounds
Substituents	Protoberberine skeleton - Isoquinoline - Anisole - Alkyl aryl ether - Pyridine - Pyridinium - Benzenoid - Heteroaromatic compound - Azacycle - Ether - Organoheterocyclic compound - Organic salt - Organic chloride salt - Organic nitrogen compound - Hydrocarbon derivative - Organooxygen compound - Organonitrogen compound - Organopnictogen compound - Organic oxygen compound - Aromatic heteropolycyclic compound
Description	This compound belongs to the class of organic compounds known as protoberberine alkaloids and derivatives. These are alkaloids with a structure based on a protoberberine moiety, which consists of a 5,6-dihydrodibenzene moiety fused to a quinolizinium and forming 5,6-Dihydrodibenzo(a,g)quinolizinium skeleton.
External Descriptors	Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

3D Structure

Associated Targets(Human)

CYP3A4 Tclin Cytochrome P450 3A4 (1 Activities)

Discover Target: CYP3A4

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ESR1 Tclin Estrogen receptor alpha (17718 Activities)

Discover Target: ESR1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

ACHE Tclin Acetylcholinesterase (18204 Activities)

Discover Target: ACHE

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

P2RX7 Tchem P2X purinoceptor 7 (5534 Activities)

Discover Target: P2RX7

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CYP3A4 Tclin Cytochrome P450 3A4 (53859 Activities)

Discover Target: CYP3A4

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

ACHN (49357 Activities)

Lot Number	Certificate Type	Date	Item
L2409539	Certificate of Analysis	Jun 11, 2026	P274975
F2306069	Certificate of Analysis	Jun 11, 2026	P274975
F2306072	Certificate of Analysis	Jun 11, 2026	P274975
F2306084	Certificate of Analysis	Jun 11, 2026	P274975
F2306087	Certificate of Analysis	Jun 11, 2026	P274975
K2415083	Certificate of Analysis	May 20, 2026	P274975
K2415084	Certificate of Analysis	May 20, 2026	P274975
H2514055	Certificate of Analysis	May 20, 2026	P274975
D2311682	Certificate of Analysis	Apr 03, 2026	P274975
F2306070	Certificate of Analysis	Feb 05, 2026	P274975
F2306067	Certificate of Analysis	Oct 29, 2025	P274975
L2409540	Certificate of Analysis	Sep 09, 2025	P274975
L2409538	Certificate of Analysis	Sep 09, 2025	P274975
L2417045	Certificate of Analysis	Nov 25, 2024	P274975
F2306082	Certificate of Analysis	Mar 20, 2024	P274975
F2306081	Certificate of Analysis	Mar 20, 2024	P274975
F2306079	Certificate of Analysis	Mar 20, 2024	P274975
F2306063	Certificate of Analysis	Mar 20, 2024	P274975

Sensitivity	Air & light & heat &Moisture sensitive
Melt Point(°C)	205 °C
Molecular Weight	387.900 g/mol
XLogP3
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	4
Exact Mass	387.124 Da
Monoisotopic Mass	387.124 Da
Topological Polar Surface Area	40.800 Å²
Heavy Atom Count	27
Formal Charge	0
Complexity	475.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	2

Palmatine chloride - Moligand™, ≥98% , CAS No.10605-02-4

Why this grade

Storage & shipping

Quality documents

Literature proof

Overview

Specifications

Documentation

📋 Safety Data Sheet (SDS)

✅ Certificate of Analysis (COA)

📊 Datasheet

🔬 Specification Sheet

Advanced Data

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