pan-TEAD-IN-1 , CAS No.3027484-09-6

CAS: 3027484-09-6 Cat. No.: P1453917 Molecular Weight: 331.33

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Overview

pan-TEAD-IN-1 (Compound 3) is an orally active pan- TEAD inhibitor targeting the palmitoylation site of TEAD , disrupting its interaction with the coactivators YAP/TAZ , thereby suppressing the transcriptional upregulation of oncogenes (e.g., Ctgf and Cyr61 ) in the Hippo signaling pathway. pan-TEAD-IN-1 exhibits excellent activity with a luciferase IC 50 of 0.36 nM and an H226 cell IC 50 of 1.52 nM. It also shows favorable pharmacokinetics (AUC 0–∞ = 228.7 μg/mL·min, T 1/2 = 183.9 min). In TEAD-dependent xenograft mouse models, pan-TEAD-IN-1 significantly inhibited tumor growth, showing promise for research in TEAD-dependent cancers.

Specifications

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Names and Identifiers

• Molecular Weight: 331.33