PF-04745637 - 10mM in DMSO , CAS No.1917294-46-2

CAS: 1917294-46-2 Cat. No.: P655035 Molecular Weight: 509.00 PubChem CID: 121304823
AVAILABLE TO ORDER
GRADE & PURITY 10mM in DMSO
Storage
Store at -80°C
Shipped In
Dry ice packs + Cold packs
 ·  off list, applied to all prices below.
Size
Status
Price
Qty
1ml
P655035-1ml
8-12 wks(?) Production requires sourcing of materials. We appreciate your patience and understanding.
$671.90
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Why this grade

10mM in DMSO for sensitive chromatographic and analytical workflows requiring minimal baseline interference.

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Storage & shipping

Store at -80°C Ships Dry ice packs + Cold packs Check lot-specific COA for exact specifications.

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Quality documents

SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.

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Literature proof

Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.

Overview

PF-04745637 is a potent and selective TRPA1 antagonist with an IC 50 of 17 nM for human TRPA1

In Vivo

Topically applied PF-04745637 (Compound 8; 50 mg/mL and 100 mg/mL) significantly reduces cinnamaldehyde-mediated flare in rat skin . MCE has not independently confirmed the accuracy of these methods. They are for reference only.

IC50& Target:TRPA1 17 nM (IC 50 )

Specifications

Specifications & Purity
10mM in DMSO
Biochemical and Physiological Mechanisms
PF-04745637 is a potent and selective TRPA1 antagonist with an IC 50 of 17 nM for human TRPA1.
Storage
Store at -80°C
Shipped In
Dry ice packs + Cold packs
This product requires cold chain shipping. Ground and other economy services are not available.
Action Type
ANTAGONIST
Names and Identifiers
Isomeric SMILES C1CCC(C1)(C2=CC=C(C=C2)Cl)C(=O)NCC(CC3=CC=CC=C3)N4CCC(CC4)(C(F)(F)F)O
PubChem CID 121304823
Molecular Weight 509.00

Documentation

📋 Safety Data Sheet (SDS)

Comprehensive hazard, handling, storage, and regulatory compliance document.

Download SDS →

✅ Certificate of Analysis (COA)

Lot-specific quality data. Enter your lot number to retrieve the exact COA.

Look up COA →

📊 Datasheet

Quick-reference summary of product specifications and applications.

View datasheet →

🔬 Specification Sheet

Full quality attributes and acceptance criteria for this grade.

View spec sheet →

Advanced Data

Associated Targets(Human)
TRPA1 Tclin Transient receptor potential cation channel subfamily A member 1 (3 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
Certificates(CoA,COO,BSE/TSE and Analysis Chart)
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:
Solution Calculators
Reviews

Customer Reviews

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