Polymyxin B nonapeptide（TFA salt）, CAS No.2220175-42-6

CAS: 2220175-42-6 Cat. No.: P646735 Molecular Weight: 963.13 (free base)

GRADE & PURITY ≥98%

Overview

Polymyxin B nonapeptide TFA is a cyclic peptide obtained from Polymyxin B by proteolytic removal of its terminal amino acyl residue. Polymyxin B nonapeptide TFA is less toxic, lacks bactericidal activity, and retains its ability to render gram-negative bacteria susceptible to several antibiotics by permeabilizing their outer membranes.

Specifications

Product Name

Polymyxin B nonapeptide（TFA salt）, CAS No.2220175-42-6

Synonyms

(2S, 3R)-2-amino-N-[(2S)-4-amino-1-oxo-1-[[(3S, 6S, 9S, 12S, 15R, 18S, 21S)-6, 9, 18-tris(2-aminoethyl)-15-benzyl-3-[(1R)-1-hydroxyethyl]-12-(2-methylpropyl)-2, 5, 8, 11, 14, 17, 20-heptaoxo-1, 4, 7, 10, 13, 16, 19-heptazacyclotricos-21-yl]amino]butan-2-yl]-3-hydroxybutanamid

Specifications & Purity

≥98%

Biochemical and Physiological Mechanisms

Polymyxin B nonapeptide is a cyclic peptide obtained from Polymyxin B by proteolytic removal of its terminal amino acyl residue. Polymyxin B nonapeptide is less toxic, lacks bactericidal activity, and retains its ability to render gram-negative bacte

Sequence

Thr-{Dab}-{Dab}-{Dab}-d-Phe-Leu-{Dab}-{Dab}-Thr (Lactam: Dab3-Thr9)

CAS

2220175-42-6

Molecule Type

Peptide

Storage and Shipping

Storage

Protected from light,Store at -20°C,Desiccated

Shipped In

Ice chest + Ice pads