Prochlorperazine Dimaleate - ≥98% , Dopamine D2 receptor antagonist, CAS No.84-02-6, Dopamine D2 receptor antagonist

CAS: 84-02-6 Cat. No.: P133613 Formule: C₂₀H₂₄ClN₃S·2C₄H₄O₄ Poids moléculaire: 606.09 Numéro CE: 201-511-3 PubChem CID: 5281032

GRADE & PURITY ≥98%

Synonyms

2-CHLORO-10-(3-(4-METHYL-1-PIPERAZINYL)PROPYL)PHENOTHIAZINE MALEATE (1:2). | Prochlorperazine maleate, British Pharmacopoeia (BP) Reference Standard | SR-01000000260 | DTXCID6028941 | Meterazin maleate | NCGC00015856-10 | Prochlorperazine dimaleate | Paso

Storage

Protected from light,Store at -20°C

Shipped In

Ice chest + Ice pads

Specifications

Synonymes

2-CHLORO-10-(3-(4-METHYL-1-PIPERAZINYL)PROPYL)PHENOTHIAZINE MALEATE (1:2). | Prochlorperazine maleate, British Pharmacopoeia (BP) Reference Standard | SR-01000000260 | DTXCID6028941 | Meterazin maleate | NCGC00015856-10 | Prochlorperazine dimaleate | Paso

Spécifications et pureté

≥98%

Mécanismes biochimiques et physiologiques

Prochlorperazine is an anti-nausea and neuroleptic agent. It is known to cause neuropsychiatric side effects. Prochlorperazine inhibits the action of dopamine in the central nervous system. It acts as an antiemetic drug and prevents vomiting and stimulate

Conditions de stockage de stockage

Protected from light,Store at -20°C

Expédié en

Ice chest + Ice pads

Ce produit nécessite l'expédition en chaîne froide. Les services terrestres et autres services économiques ne sont pas disponibles.

Type d'action

ANTAGONIST

Mécanisme d'action

Dopamine D2 receptor antagonist

Pureté

≥98%

Noms et identifiants

Pubchem Sid

504763322

Pubchem Sid Url

https://pubchem.ncbi.nlm.nih.gov/substance/504763322

Sourires canoniques

CN1CCN(CC1)CCCN2C3=CC=CC=C3SC4=C2C=C(C=C4)Cl.C(=CC(=O)O)C(=O)O.C(=CC(=O)O)C(=O)O

IUPAC Name

(Z)-but-2-enedioic acid;2-chloro-10-[3-(4-methylpiperazin-1-yl)propyl]phenothiazine

InChIKey

DSKIOWHQLUWFLG-SPIKMXEPSA-N

INCHI

1S/C20H24ClN3S.2C4H4O4/c1-22-11-13-23(14-12-22)9-4-10-24-17-5-2-3-6-19(17)25-20-8-7-16(21)15-18(20)24;2*5-3(6)1-2-4(7)8/h2-3,5-8,15H,4,9-14H2,1H3;2*1-2H,(H,5,6)(H,7,8)/b;2*2-1-

Isomères SMILES

CN1CCN(CC1)CCCN2C3=C(SC4=CC=CC=C24)C=CC(=C3)Cl.C(=C\C(=O)O)\C(=O)O.C(=C\C(=O)O)\C(=O)O

WGK Allemagne

3

RTECS

SO3150000

PubChem CID

5281032

Poids moléculaire

606.09

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organoheterocyclic compounds
    • Classe Benzothiazines
      • Subclass Phenothiazines

• Kingdom: Organic compounds
• Superclass: Organoheterocyclic compounds
• Classe: Benzothiazines
• Subclass: Phenothiazines
• Intermediate Tree Nodes: Not available
• Direct Parent: Phenothiazines
• Alternative Parents: Alkyldiarylamines Diarylthioethers N-methylpiperazines 1,4-thiazines Unsaturated fatty acids Aryl chlorides Benzenoids Dicarboxylic acids and derivatives Trialkylamines Carboxylic acids Azacyclic compounds Carbonyl compounds Hydrocarbon derivatives Organopnictogen compounds Organic oxides Organochlorides
• Molecular Framework: Not available
• Substituents: Phenothiazine - Alkyldiarylamine - Diarylthioether - Aryl thioether - Tertiary aliphatic/aromatic amine - N-methylpiperazine - N-alkylpiperazine - Para-thiazine - Aryl chloride - Aryl halide - 1,4-diazinane - Dicarboxylic acid or derivatives - Piperazine - Unsaturated fatty acid - Benzenoid - Fatty acid - Fatty acyl - Tertiary amine - Tertiary aliphatic amine - Azacycle - Carboxylic acid - Carboxylic acid derivative - Thioether - Organochloride - Organohalogen compound - Hydrocarbon derivative - Organic oxygen compound - Organopnictogen compound - Organic oxide - Amine - Organonitrogen compound - Organooxygen compound - Organic nitrogen compound - Carbonyl group - Aromatic heteropolycyclic compound
• Description: This compound belongs to the class of organic compounds known as phenothiazines. These are polycyclic aromatic compounds containing a phenothiazine moiety, which is a linear tricyclic system that consists of a two benzene rings joined by a para-thiazine ring.
• External Descriptors: maleate salt

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Cibles associées (humaines)

CYP1A2 Tchem Cytochrome P450 1A2 (0 Activities)

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CYP2D6 Tclin Cytochrome P450 2D6 (0 Activities)

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DRD1 Tclin D(1A) dopamine receptor (0 Activities)

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DRD2 Tclin D(2) dopamine receptor (0 Activities)

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HRH1 Tclin Histamine H1 receptor (0 Activities)

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SLC6A2 Tclin Sodium-dependent noradrenaline transporter (0 Activities)

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SLC6A4 Tclin Sodium-dependent serotonin transporter (0 Activities)

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SIGMAR1 Tclin Sigma non-opioid intracellular receptor 1 (0 Activities)

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DRD3 Tclin D(3) dopamine receptor (0 Activities)

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ADRA2B Tclin Alpha-2B adrenergic receptor (0 Activities)

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ADRA2C Tclin Alpha-2C adrenergic receptor (0 Activities)

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HTR2A Tclin 5-hydroxytryptamine receptor 2A (0 Activities)

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ADRA2A Tclin Alpha-2A adrenergic receptor (0 Activities)

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ADRA1D Tclin Alpha-1D adrenergic receptor (0 Activities)

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HTR2C Tclin 5-hydroxytryptamine receptor 2C (0 Activities)

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HTR2B Tclin 5-hydroxytryptamine receptor 2B (0 Activities)

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KCNH2 Tclin Potassium voltage-gated channel subfamily H member 2 (0 Activities)

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KCNH2 Tclin HERG (29587 Activities)

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GBA1 Tclin Beta-glucocerebrosidase (14647 Activities)

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HEK293 (82097 Activities)

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POLI Tchem DNA polymerase iota (116820 Activities)

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TDP1 Tchem Tyrosyl-DNA phosphodiesterase 1 (345557 Activities)

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KDM4E Tchem Lysine-specific demethylase 4D-like (40243 Activities)

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SMN1 Tchem Survival motor neuron protein (34246 Activities)

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LMNA Tbio Prelamin-A/C (36751 Activities)

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GMNN Tbio Geminin (128009 Activities)

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PMP22 Tbio Peripheral myelin protein 22 (699 Activities)

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MPHOSPH8 Tbio M-phase phosphoprotein 8 (656 Activities)

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MEN1 Tchem Menin/Histone-lysine N-methyltransferase MLL (48157 Activities)

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Cibles associées (non humaines)

Mapk1 MAP kinase ERK2 (650 Activities)

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Pseudomonas aeruginosa (123386 Activities)

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Klebsiella pneumoniae (43867 Activities)

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Staphylococcus aureus (210822 Activities)

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Acinetobacter baumannii (41033 Activities)

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Escherichia coli (133304 Activities)

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Plasmodium falciparum (966862 Activities)

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Cryptococcus neoformans (21258 Activities)

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Candida albicans (78123 Activities)

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Npsr1 Neuropeptide S receptor (260 Activities)

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Txnrd1 Thioredoxin reductase 1, cytoplasmic (45279 Activities)

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Mapt Microtubule-associated protein tau (6 Activities)

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Impa1 Inositol monophosphatase 1 (16203 Activities)

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nfo Endonuclease 4 (425 Activities)

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NS1 Nonstructural protein 1 (33327 Activities)

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Mécanismes d'action

Propriétés chimiques et physiques

• Sensibilité: Light sensitive
• Poids moléculaire: 606.100 g/mol
• Hydrogen Bond Donor Count: 4
• Hydrogen Bond Acceptor Count: 12
• Rotatable Bond Count: 8
• Exact Mass: 605.16 Da
• Monoisotopic Mass: 605.16 Da
• Topological Polar Surface Area: 184.000 Ų
• Heavy Atom Count: 41
• Formal Charge: 0
• Complexity: 548.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 2
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 2
• Covalently-Bonded Unit Count: 3

XLogP3

Foire aux questions

What is the purity of this product?

This product is supplied at ≥98% purity (chemical assay). Lot-specific values are stated on the Certificate of Analysis.

How should this product be stored?

Store at ?20 °C, protected from light. The material is light-sensitive — keep it in its original opaque or amber container.

How is this product shipped?

This product ships in an insulated container with ice pads. Unpack on arrival and transfer it to the storage condition stated above.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 84-02-6, the molecular formula is C20H24ClN3S·2C4H4O4, and the molecular weight is 606.09 g/mol. InChIKey DSKIOWHQLUWFLG-SPIKMXEPSA-N.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.