Psalmotoxin 1 TFA, CAS No.316808-68-1 (free base)

CAS: 316808-68-1 (free base) Cat. No.: P1417450 Molecular Weight: 4689.39 (free base)

GRADE & PURITY BioReagent, ≥95%(HPLC)

Accession #

P60514

Overview

Psalmotoxin 1 (PcTx1) TFA  is a protein toxin that can bind at subunit-subunit interfaces of acid-sensing ion channel 1a (ASIC1a). Psalmotoxin 1 is a potent and selective ASIC1a inhibitor (IC₅₀: 0.9 nM) by increasing the apparent affinity for H⁺ of ASIC1a. Psalmotoxin 1 can induce cell apoptosis, also inhibits cell migration, proliferation and invasion of cancer cells. Psalmotoxin 1 can be used in the research of cancers, or neurological disease.

Sequence: Glu-Asp-Cys-Ile-Pro-Lys-Trp-Lys-Gly-Cys-Val-Asn-Arg-His-Gly-Asp-Cys-Cys-Glu-Gly-Leu-Glu-Cys-Trp-Lys-Arg-Arg-Arg-Ser-Phe-Glu-Val-Cys-Val-Pro-Lys-Thr-Pro-Lys-Thr (Disulfide bridge: Cys3-Cys18, Cys10-Cys23, Cys17-Cys33)

Formula:  C₂₀₀H₃₁₂N₆₂O₅₇S₆・xC₂HF₃O₂ 

Molecular weight: 4689.41（free base） 

Specifications

Product Name

Psalmotoxin 1 TFA, CAS No.316808-68-1 (free base)

Synonyms

PcTx1 | Psalmopoeus cambridgei toxin-1 | Psalmotoxin 1

Grade

BioReagent

Specifications & Purity

BioReagent, ≥95%(HPLC)

Biochemical and Physiological Mechanisms

This toxin is a gating modifier that acts principally as an inhibitor on ASIC1a (ASIC isoform 2) and a potentiator on ASIC1b (ASIC isoform 3). This toxin potently and selectively inhibits rat, mouse and human ASIC1a (IC50=0.35-3.7 nM). The blockade is rap

Amino Acids

1-40 aa

Sequence

EDCIPKWKGCVNRHGDCCEGLECWKRRRSFEVCVPKTPKT

Accession #

P60514

Predicted molecular weight

4689.41（free base）

CAS

316808-68-1 (free base)

Molecule Type

Peptide

Storage and Shipping

Reconstitution

Reconstitute in water.

Storage

Protected from light,Store at -20°C,Desiccated,Avoid repeated freezing and thawing

Shipped In

Ice chest + Ice pads

Stability And Storage

Store at -20℃ long term (24 months). Upon reconstitution, it is recommended to aliquot. Avoid freeze/thaw cycle. Store in the dark. Desiccated.