Pyrazoloacridine - ≥98% , CAS No.99009-20-8

Name: Pyrazoloacridine - ≥98% , CAS No.99009-20-8
Brand: Aladdin Scientific
SKU: P646903
Availability: InStock

CAS: 99009-20-8 Cat. No.: P646903 Molecular Weight: 367.40 PubChem CID: 339455

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Pyrazoloacridine - ≥98% CAS No(99009-20-8) by Aladdin Scientific

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AVAILABLE TO ORDER

GRADE & PURITY ≥98%

Synonyms

L24XJN68OW | PD 115,934 | N,N-Dimethyl-9-methoxy-5-nitropyrazolo(3,4,5-kl)acridine-2(6H)-propanamine | BRN 4211902 | DB12549 | AKOS024419418 | PD-115934 | Neuro_000206 | Q27282607 | 3-Amino-5-methoxybenzotrifluoride; 5-Trifluoromethyl-m-anisidine | Pyrazo

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Size

Status

Price

Qty

5mg

P646903-5mg

8-12 wks(?)

$360.90

10mg

P646903-10mg

8-12 wks(?)

$580.90

25mg

P646903-25mg

8-12 wks(?)

$1,160.90

50mg

P646903-50mg

8-12 wks(?)

$1,860.90

100mg

P646903-100mg

8-12 wks(?)

$2,960.90

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Overview Specifications Names and Identifiers Documentation Advanced Data Taxonomic Classification 3D Structure Associated Targets(Human) Associated Targets(non-human) Mechanisms of Action Certificates（CoA,COO,BSE/TSE and Analysis Chart) Chemical and Physical Properties Solution Calculators Reviews

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Why this grade

≥98% for sensitive chromatographic and analytical workflows requiring minimal baseline interference.

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Storage & shipping

Store at -20°C Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.

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Quality documents

SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.

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Literature proof

Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.

Overview

Pyrazoloacridine (NSC 366140), an intercalating agent with anti-cancer activity, inhibits the activity of topoisomerases 1 and 2. Pyrazoloacridine (NSC 366140) exhibits an IC 50 of 1.25 μM in K562 myeloid leukemia cells for 24 h treatment.

In Vitro

Pyrazoloacridine (NSC 366140, PD 115934) exhibits IC 50 values of 10.7 μM and 4.5 μM for oxic and hypoxic HCT-8 cells. Pyrazoloacridine (NSC 366140, 2-4 μM) abolishes the catalytic activity of both topo I and topo II in vitro. Pyrazoloacridine (NSC 366140) displays activity against cisplatin- and paclitaxel-resistant ovarian cancer. Pyrazoloacridine (NSC 366140) has been shown to cause delayed DNA fragmentation in MCF-7 breast cancer cells. Pyrazoloacridine (NSC 366140) induces apoptosis in P53-deficient Hep 3B human hepatoma cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Cytotoxicity AssayCell Line: K562 Myeloid Leukemia Cells. Concentration: 0-500 μM. Incubation Time: 1 h or 24 h. Result: When K562 cells were incubated with PA for 1 h and then plated in soft agar, an IC 50 of -50 μM was observed. In contrast, when cells were incubated for 24 h with PA, the IC 50 was 1.25 μM.

Form:Solid

Specifications

Synonyms

L24XJN68OW | PD 115, 934 | N, N-Dimethyl-9-methoxy-5-nitropyrazolo(3, 4, 5-kl)acridine-2(6H)-propanamine | BRN 4211902 | DB12549 | AKOS024419418 | PD-115934 | Neuro_000206 | Q27282607 | 3-Amino-5-methoxybenzotrifluoride; 5-Trifluoromethyl-m-anisidine | Pyrazo

Specifications & Purity

≥98%

Biochemical and Physiological Mechanisms

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Purity

≥98%

Names and Identifiers

Canonical Smiles	CN(C)CCCN1C2=C3C(=C(C=C2)[N+](=O)[O-])NC4=C(C3=N1)C=C(C=C4)OC
IUPAC Name	3-(4-methoxy-10-nitro-8,14,15-triazatetracyclo[7.6.1.02,7.013,16]hexadeca-1(15),2(7),3,5,9,11,13(16)-heptaen-14-yl)-N,N-dimethylpropan-1-amine
InChIKey	HZCWPKGYTCJSEB-UHFFFAOYSA-N
INCHI	1S/C19H21N5O3/c1-22(2)9-4-10-23-15-7-8-16(24(25)26)19-17(15)18(21-23)13-11-12(27-3)5-6-14(13)20-19/h5-8,11,20H,4,9-10H2,1-3H3
Isomeric SMILES	CN(C)CCCN1C2=C3C(=C(C=C2)[N+](=O)[O-])NC4=C(C3=N1)C=C(C=C4)OC
Alternate CAS	99009-20-8,99009-21-9 (methanesulfonate salt)
PubChem CID	339455
NSC Number	627168
MeSH Entry Terms	9-methoxy-N,N-dimethyl-5-nitropyrazolo(3,4,5-k)acridine-2(6H)-propanamine;NSC 366140;NSC 366140, methanesulfonate salt;NSC-366140;PD 115934;PD-115934;pyrazoloacridine;pyrazoloacridine mesylate
Molecular Weight	367.40

Documentation

📋 Safety Data Sheet (SDS)

Comprehensive hazard, handling, storage, and regulatory compliance document.

Download SDS →

✅ Certificate of Analysis (COA)

Lot-specific quality data. Enter your lot number to retrieve the exact COA.

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📊 Datasheet

Quick-reference summary of product specifications and applications.

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🔬 Specification Sheet

Full quality attributes and acceptance criteria for this grade.

View spec sheet →

Advanced Data

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Organoheterocyclic compounds
  - Class Quinolines and derivatives
    - Subclass Benzoquinolines

Kingdom	Organic compounds
Superclass	Organoheterocyclic compounds
Class	Quinolines and derivatives
Subclass	Benzoquinolines
Intermediate Tree Nodes	Not available
Direct Parent	Acridines
Alternative Parents	Indazoles Nitroaromatic compounds Anisoles Alkyl aryl ethers Pyridines and derivatives Pyrazoles Heteroaromatic compounds Trialkylamines Propargyl-type 1,3-dipolar organic compounds Organic oxoazanium compounds Azacyclic compounds Organic zwitterions Organic salts Organic oxides Hydrocarbon derivatives
Molecular Framework	Aromatic heteropolycyclic compounds
Substituents	Acridine - Benzopyrazole - Indazole - Nitroaromatic compound - Anisole - Phenol ether - Alkyl aryl ether - Pyridine - Benzenoid - Azole - Heteroaromatic compound - Pyrazole - Organic nitro compound - C-nitro compound - Tertiary amine - Tertiary aliphatic amine - Propargyl-type 1,3-dipolar organic compound - Organic 1,3-dipolar compound - Organic oxoazanium - Ether - Azacycle - Allyl-type 1,3-dipolar organic compound - Organic salt - Organooxygen compound - Organonitrogen compound - Organic oxygen compound - Organic nitrogen compound - Hydrocarbon derivative - Amine - Organic oxide - Organic zwitterion - Aromatic heteropolycyclic compound
Description	This compound belongs to the class of organic compounds known as acridines. These are organic compounds containing the acridine moiety, a linear tricyclic heterocycle which consists of two benzene rings joined by a pyridine ring.
External Descriptors	Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

3D Structure

Associated Targets(Human)

TOP1 Tclin DNA topoisomerase I (7553 Activities)

Discover Target: TOP1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

NQO1 Tchem Quinone reductase 1 (1746 Activities)

Discover Target: NQO1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

A498 (42825 Activities)

Solubility	DMSO : 16.67 mg/mL (45.37 mM; ultrasonic and warming and heat to 60°C)
Molecular Weight	367.400 g/mol
XLogP3	3.000
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	5
Exact Mass	367.164 Da
Monoisotopic Mass	367.164 Da
Topological Polar Surface Area	88.100 Å²
Heavy Atom Count	27
Formal Charge	0
Complexity	542.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	1

Pyrazoloacridine - ≥98% , CAS No.99009-20-8

Why this grade

Storage & shipping

Quality documents

Literature proof

Overview

Specifications

Documentation

📋 Safety Data Sheet (SDS)

✅ Certificate of Analysis (COA)

📊 Datasheet

🔬 Specification Sheet

Advanced Data

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

Customer Reviews

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