SL-327 - Moligand™, ≥98%, mixture of isomers , Inhibitor of mitogen-activated protein kinase kinase 2, CAS No.305350-87-2, Inhibitor of mitogen-activated protein kinase kinase 2

CAS: 305350-87-2 Cat. No.: S125929 Molecular Weight: 335.35 EC Number: 878-717-0 PubChem CID: 9549284

GRADE & PURITY Moligand™, ≥98%, mixture of isomers

Synonyms

CCG-206867 | STL555675 | Benzeneacetonitrile, alpha-[amino[(4-aminophenyl)thio]methylene]-2-(trifluoromethyl)- | HY-15437 | SCHEMBL570318 | BCP05310 | FT-0600361 | Q27084156 | AC-33170 | NCGC00092290-01 | (Z)-3-Amino-3-((4-aminophenyl)thio)-2-(2-(trifluor

Storage

Store at -20°C,Argon charged

Shipped In

Ice chest + Ice pads

Overview

SL327 inhibits MEK1 and MEK2, with IC50 values of 180 nM and 220 nM, respectively.

Specifications

Synonyms

CCG-206867 | STL555675 | Benzeneacetonitrile, alpha-[amino[(4-aminophenyl)thio]methylene]-2-(trifluoromethyl)- | HY-15437 | SCHEMBL570318 | BCP05310 | FT-0600361 | Q27084156 | AC-33170 | NCGC00092290-01 | (Z)-3-Amino-3-((4-aminophenyl)thio)-2-(2-(trifluor

Specifications & Purity

Moligand™, ≥98%, mixture of isomers

Biochemical and Physiological Mechanisms

SL-327 is a cell-permeable vinylogous cyanamide that acts as a selective inhibitor of MEK-1 and MEK-2 (IC50 = 0.18 and 0.22 μM respectively). SL-327 has been shown to block hippocampal LTP via inhibition of the MAPK/ERK cascade, which prevents CREB and

Storage

Store at -20°C, Argon charged

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Grade

Moligand™

Action Type

INHIBITOR

Mechanism of action

Inhibitor of mitogen-activated protein kinase kinase 2

Note

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Purity

≥98%

Names and Identifiers

• Pubchem Sid: 504764808
• Pubchem Sid Url: https://pubchem.ncbi.nlm.nih.gov/substance/504764808
• Canonical Smiles: C1=CC=C(C(=C1)C(=C(N)SC2=CC=C(C=C2)N)C#N)C(F)(F)F
• IUPAC Name: (Z)-3-amino-3-(4-aminophenyl)sulfanyl-2-[2-(trifluoromethyl)phenyl]prop-2-enenitrile
• InChIKey: JLOXTZFYJNCPIS-FYWRMAATSA-N
• INCHI: 1S/C16H12F3N3S/c17-16(18,19)14-4-2-1-3-12(14)13(9-20)15(22)23-11-7-5-10(21)6-8-11/h1-8H,21-22H2/b15-13+
• Isomeric SMILES: C1=CC=C(C(=C1)/C(=C(\N)/SC2=CC=C(C=C2)N)/C#N)C(F)(F)F
• WGK Germany: 3
• PubChem CID: 9549284
• Molecular Weight: 335.35

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Benzenoids
    • Class Benzene and substituted derivatives
      • Subclass Trifluoromethylbenzenes

• Kingdom: Organic compounds
• Superclass: Benzenoids
• Class: Benzene and substituted derivatives
• Subclass: Trifluoromethylbenzenes
• Intermediate Tree Nodes: Not available
• Direct Parent: Trifluoromethylbenzenes
• Alternative Parents: Aryl thioethers Aniline and substituted anilines Ketene acetals Sulfenyl compounds Nitriles Primary amines Organofluorides Hydrocarbon derivatives Alkyl fluorides
• Molecular Framework: Aromatic homomonocyclic compounds
• Substituents: Trifluoromethylbenzene - Aniline or substituted anilines - Aryl thioether - Ketene acetal or derivatives - Sulfenyl compound - Nitrile - Carbonitrile - Hydrocarbon derivative - Organic nitrogen compound - Primary amine - Organosulfur compound - Organonitrogen compound - Organofluoride - Organohalogen compound - Alkyl fluoride - Amine - Alkyl halide - Cyanide - Aromatic homomonocyclic compound
• Description: This compound belongs to the class of organic compounds known as trifluoromethylbenzenes. These are organofluorine compounds that contain a benzene ring substituted with one or more trifluoromethyl groups.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Associated Targets(Human)

MAP2K2 Tclin Dual specificity mitogen-activated protein kinase kinase 2 (1 Activities)

Discover Target: MAP2K2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Chemical and Physical Properties

• Solubility: DMSO 4 mg/mL Water <1 mg/mL Ethanol 7 mg/mL
• Sensitivity: Light Sensitive,Air Sensitive,Moisture Sensitive,Heat Sensitive
• Melt Point(°C): 128 °C
• Molecular Weight: 335.300 g/mol
• XLogP3: 3.700
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 7
• Rotatable Bond Count: 3
• Exact Mass: 335.07 Da
• Monoisotopic Mass: 335.07 Da
• Topological Polar Surface Area: 101.000 Ų
• Heavy Atom Count: 23
• Formal Charge: 0
• Complexity: 487.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 1
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 1
• Covalently-Bonded Unit Count: 1