(±)-Sulfinpyrazone - Moligand™, 10mM in DMSO , Antagonist of FPR1;Inhibitor of Urate anion exchanger 1, CAS No.57-96-5, Antagonist of FPR1;Inhibitor of Urate anion exchanger 1

CAS: 57-96-5 Cat. No.: S424870 Molecular Weight: 404.48 EC Number: 200-357-4 PubChem CID: 5342

GRADE & PURITY Moligand™, 10mM in DMSO

Synonyms

sulfinpyrazone|57-96-5|Sulphinpyrazone|Anturane|(+/-)-SULFINPYRAZONE|Sulfinpyrazon|Anturan|Diphenylpyrazone|Sulfoxyphenylpyrazolidine|Anturanil|Anturidin|Enturen|Anturano|1,2-Diphenyl-4-(2-(phenylsulfinyl)ethyl)pyrazolidine-3,5-dione|USAF GE-13|Sulfinpyra

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

Product Describtion:

Sulfinpyrazone is a free radical scavenger that is an inhibitor of organic anion transporters (OATP) and is an effective uricosuric chemical. It is a proposed nonselective UGT (UDP-glucuronosyltransferases) inhibitor. The transport of sulfinpyrazone in MDCKII-MRP1 cells is associated with GSH export, except in high concentrations, and is a substrate for MRP2 (multidrug resistance protein).

Product Application：

cleaning products，cosmetics，food and beverages，forensics and toxicology，personal care，pharmaceutical (small molecule)，veterinary

Specifications

Synonyms

sulfinpyrazone | 57-96-5 | Sulphinpyrazone | Anturane | (+/-)-SULFINPYRAZONE | Sulfinpyrazon | Anturan | Diphenylpyrazone | Sulfoxyphenylpyrazolidine | Anturanil | Anturidin | Enturen | Anturano | 1, 2-Diphenyl-4-(2-(phenylsulfinyl)ethyl)pyrazolidine-3, 5-dione | USAF GE-13 | Sulfinpyra

Specifications & Purity

Moligand™, 10mM in DMSO

Biochemical and Physiological Mechanisms

Sulfamethoxazole, one of the most studied inhibitors of Platelet Cox, is an acid excretory agent that reabsorbs Competitive inhibition acid in the proximal tubules of the kidney.

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Grade

Moligand™

Action Type

ANTAGONIST, INHIBITOR

Mechanism of action

Antagonist of FPR1;Inhibitor of Urate anion exchanger 1

Names and Identifiers

• Canonical Smiles: C1=CC=C(C=C1)N2C(=O)C(C(=O)N2C3=CC=CC=C3)CCS(=O)C4=CC=CC=C4
• IUPAC Name: 4-[2-(benzenesulfinyl)ethyl]-1,2-diphenylpyrazolidine-3,5-dione
• InChIKey: MBGGBVCUIVRRBF-UHFFFAOYSA-N
• INCHI: 1S/C23H20N2O3S/c26-22-21(16-17-29(28)20-14-8-3-9-15-20)23(27)25(19-12-6-2-7-13-19)24(22)18-10-4-1-5-11-18/h1-15,21H,16-17H2
• Isomeric SMILES: C1=CC=C(C=C1)N2C(=O)C(C(=O)N2C3=CC=CC=C3)CCS(=O)C4=CC=CC=C4
• WGK Germany: 3
• RTECS: UQ8575000
• PubChem CID: 5342
• Molecular Weight: 404.48

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Benzenoids
    • Class Benzene and substituted derivatives
      • Subclass Phenyl sulfoxides

• Kingdom: Organic compounds
• Superclass: Benzenoids
• Class: Benzene and substituted derivatives
• Subclass: Phenyl sulfoxides
• Intermediate Tree Nodes: Not available
• Direct Parent: Phenyl sulfoxides
• Alternative Parents: Pyrazolidinones 1,3-dicarbonyl compounds Sulfoxides Carboxylic acid hydrazides Sulfinyl compounds Azacyclic compounds Organopnictogen compounds Organonitrogen compounds Organic oxides Hydrocarbon derivatives
• Molecular Framework: Aromatic heteromonocyclic compounds
• Substituents: Phenyl sulfoxide - Pyrazolidinone - 1,3-dicarbonyl compound - Pyrazolidine - Carboxylic acid hydrazide - Sulfoxide - Carboxylic acid derivative - Azacycle - Organoheterocyclic compound - Sulfinyl compound - Carbonyl group - Hydrocarbon derivative - Organic oxide - Organopnictogen compound - Organosulfur compound - Organooxygen compound - Organonitrogen compound - Organic oxygen compound - Organic nitrogen compound - Aromatic heteromonocyclic compound
• Description: This compound belongs to the class of organic compounds known as phenyl sulfoxides. These are organosulfur compounds containing a sulfoxide group substituted with a phenyl group.
• External Descriptors: sulfoxide - pyrazolidines

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Associated Targets(Human)

SLC22A12 Tclin Solute carrier family 22 member 12 (1 Activities)

Discover Target: SLC22A12

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

FPR1 Tchem fMet-Leu-Phe receptor (1 Activities)

Discover Target: FPR1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

NAPRT Tchem Nicotinate phosphoribosyltransferase (0 Activities)

Discover Target: NAPRT

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Chemical and Physical Properties

• Melt Point(°C): 131 °C
• Molecular Weight: 404.500 g/mol
• XLogP3: 2.300
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 6
• Exact Mass: 404.119 Da
• Monoisotopic Mass: 404.119 Da
• Topological Polar Surface Area: 76.900 Ų
• Heavy Atom Count: 29
• Formal Charge: 0
• Complexity: 571.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 1
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1

References

1. Jingxuan Qiu, Xinzhu Zhao, Gang Liu, Chaoqun Zhang, Libo Wang, Yeming Wang, Shizhe Li, Lei Wang, Cen Yao, Liping Zhao, Peng Wang, Jia Zhang, Jing Lin, Rui Zhang, Yunchun Guo, Huiliang Wang.  (2023)  Solubility Behavior and Data Correlation of Sulfinpyrazone in Thirteen Pure Solvents from 283.15 to 323.15 K.  JOURNAL OF CHEMICAL AND ENGINEERING DATA,      [PMID:] [10.1021/acs.jced.3c00463]

2. Chen Sun, Mingyu Zhang, Yanhong Zhao, Jianxin Pang, Ying Peng, Jiang Zheng.  (2020)  An LC-MS/MS- and hURAT1 cell-based approach for screening of uricosuric agents.  JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES,      [PMID:32905987] [10.1016/j.jchromb.2020.122336]

3. Chen Chen, Peng Shi, Haihua Wu, Tingting Zhang, Min Zhang, Xueyao Zhang.  (2026)  The transcription factor CncC/Maf modulates imidacloprid susceptibility by regulating UGT392C1 in Locusta migratoria.  PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY,      [PMID:41831881] [10.1016/j.pestbp.2026.107013]