TCID - Moligand™, ≥97% , Inhibitor of ubiquitin C-terminal hydrolase L3, CAS No.30675-13-9, Inhibitor of ubiquitin C-terminal hydrolase L3

CAS: 30675-13-9 Cat. No.: T169439 Molecular Weight: 283.92 EC Number: 970-953-3 PubChem CID: 2729042

GRADE & PURITY Moligand™, ≥97%

Synonyms

4,5,6,7-Tetrachloroindane-1,3-dione | C9H2Cl4O2 | Maybridge1_006552 | GTPL8660 | HMS3653C11 | HMS560B18 | UCH 23;UCH23;UCH-23;UCH-L3 Inhibitor;4,5,6,7-tetrachloroindan-1,3-dione | UCH-L3 | UCH-L3 Inhibitor | 4,5,6,7-Tetrachloro indane-1,3-dione | HY-18638

Storage

Store at 2-8°C

Shipped In

Wet ice

Specifications

Synonyms

4, 5, 6, 7-Tetrachloroindane-1, 3-dione | C9H2Cl4O2 | Maybridge1_006552 | GTPL8660 | HMS3653C11 | HMS560B18 | UCH 23;UCH23;UCH-23;UCH-L3 Inhibitor;4, 5, 6, 7-tetrachloroindan-1, 3-dione | UCH-L3 | UCH-L3 Inhibitor | 4, 5, 6, 7-Tetrachloro indane-1, 3-dione | HY-18638

Specifications & Purity

Moligand™, ≥97%

Biochemical and Physiological Mechanisms

TCID is a cell penetrant potent and specific inhibitor of UCH-L3 (Ubiquitin carboxyl-terminal hydrolase isozyme L3). TCID is used to distinguish between UCH-L1 and UCH-L3 activities in cells.

Storage

Store at 2-8°C

Shipped In

Wet ice

This product requires cold chain shipping. Ground and other economy services are not available.

Grade

Moligand™

Action Type

INHIBITOR

Mechanism of action

Inhibitor of ubiquitin C-terminal hydrolase L3

Note

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Purity

≥97%

Names and Identifiers

• Pubchem Sid: 504760957
• Pubchem Sid Url: https://pubchem.ncbi.nlm.nih.gov/substance/504760957
• Canonical Smiles: C1C(=O)C2=C(C1=O)C(=C(C(=C2Cl)Cl)Cl)Cl
• IUPAC Name: 4,5,6,7-tetrachloroindene-1,3-dione
• InChIKey: IDLAOWFFKWRNHB-UHFFFAOYSA-N
• INCHI: 1S/C9H2Cl4O2/c10-6-4-2(14)1-3(15)5(4)7(11)9(13)8(6)12/h1H2
• Isomeric SMILES: C1C(=O)C2=C(C1=O)C(=C(C(=C2Cl)Cl)Cl)Cl
• PubChem CID: 2729042
• Molecular Weight: 283.92

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Benzenoids
    • Class Indanes
      • Subclass Indanones

• Kingdom: Organic compounds
• Superclass: Benzenoids
• Class: Indanes
• Subclass: Indanones
• Intermediate Tree Nodes: Not available
• Direct Parent: Indanediones
• Alternative Parents: Aryl alkyl ketones Beta-diketones Aryl chlorides Vinylogous halides Organochlorides Organic oxides Hydrocarbon derivatives
• Molecular Framework: Aromatic homopolycyclic compounds
• Substituents: Indanedione - Aryl ketone - Aryl alkyl ketone - 1,3-diketone - Aryl chloride - Aryl halide - 1,3-dicarbonyl compound - Vinylogous halide - Ketone - Organooxygen compound - Organochloride - Organohalogen compound - Organic oxygen compound - Organic oxide - Hydrocarbon derivative - Aromatic homopolycyclic compound
• Description: This compound belongs to the class of organic compounds known as indanediones. These are compounds containing an indane ring bearing two ketone groups.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Associated Targets(Human)

UCHL3 Tchem Ubiquitin carboxyl-terminal hydrolase isozyme L3 (2 Activities)

Discover Target: UCHL3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

UCHL1 Tchem Ubiquitin carboxyl-terminal hydrolase isozyme L1 (107 Activities)

Discover Target: UCHL1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

UCHL3 Tchem Ubiquitin carboxyl-terminal hydrolase isozyme L3 (50 Activities)

Discover Target: UCHL3

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

Hdac6 Histone deacetylase 6 (222 Activities)

Discover Target: Hdac6

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

rep Replicase polyprotein 1ab (378 Activities)

Discover Target: rep

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Chemical and Physical Properties

• Solubility: DMSO: 5 mg/mL, clear
• Molecular Weight: 283.900 g/mol
• XLogP3: 3.900
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 283.878 Da
• Monoisotopic Mass: 281.881 Da
• Topological Polar Surface Area: 34.100 Ų
• Heavy Atom Count: 15
• Formal Charge: 0
• Complexity: 289.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1

References

1. Shaowei Bo, Dong Zhang, Mengjie Ma, Xukai Mo, Julia Stabinska, Michael T. McMahon, Changzheng Shi, Liangping Luo.  (2023)  Acyl Hydrazides and Acyl Hydrazones as High-Performance Chemical Exchange Saturation Transfer MRI Contrast Agents.  Pharmaceuticals,  16  (5): (639).  [PMID:37242423] [10.3390/ph16050639]

2. Wang Qian, He Yuan, Lu Rui, Wang Wen-Ming, Yang Ke-Wu, Fan Hai Ming, Jin Yi, Blackburn G. Michael.  (2018)  Thermokinetic profile of NDM-1 and its inhibition by small carboxylic acids.  BIOSCIENCE REPORTS,  38  (2):   [PMID:29507059] [10.1042/BSR20180244]

3. Guiying Zhu, Chaozheng Liu, Changli Zhang, Jiangtao Shi, Changtong Mei, Mingzhu Pan, Zhipeng Liu.  (2024)  Activating the Room-Temperature Phosphorescence of Organic Dyes through the Confinement Effect of Delignified Wood.  ACS Sustainable Chemistry & Engineering,      [PMID:] [10.1021/acssuschemeng.3c07507]

4. Binhao Wang, Yu Shen, Ruonan Hao, Shuheng Pan, Ruizhi Han, Ye Ni.  (2025)  Novel Approach for Efficient Separation of Primary Amines Using Supercritical Fluid Chromatography.  CHIRALITY,  37  (1): (e70012).  [PMID:39800655] [10.1002/chir.70012]