UDP-G - ≥98% , CAS No.28053-08-9

CAS: 28053-08-9 Cat. No.: U303319 Molecular Weight: 610.27 EC Number: 248-801-6 PubChem CID: 119803

GRADE & PURITY ≥98%

Synonyms

A855605 | UNII-UYD77NZ2JQ | Cogalactoisomerase sodium salt | UDP-Glucose sodium salt | Uridine(5')disodiodiphospho(1)-alpha-D-glucose | DisodiumUDP-glucose | J-700267 | Bivitox (TN) | Uridine 5'-diphosphoglucose disodium sal | disodium;[[(2R,3S,4R,5R)-5-(

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Specifications

Synonyms

A855605 | UNII-UYD77NZ2JQ | Cogalactoisomerase sodium salt | UDP-Glucose sodium salt | Uridine(5')disodiodiphospho(1)-alpha-D-glucose | DisodiumUDP-glucose | J-700267 | Bivitox (TN) | Uridine 5'-diphosphoglucose disodium sal | disodium;[[(2R, 3S, 4R, 5R)-5-(

Specifications & Purity

≥98%

Biochemical and Physiological Mechanisms

Highly potent, endogenous P2Y 14 agonist (EC 50 = 82 nM). Involved in modulation of gastric function. UDP also available .

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Note

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Purity

≥98%

Names and Identifiers

• Pubchem Sid: 488187615
• Pubchem Sid Url: https://pubchem.ncbi.nlm.nih.gov/substance/488187615
• Canonical Smiles: C1=CN(C(=O)NC1=O)C2C(C(C(O2)COP(=O)([O-])OP(=O)([O-])OC3C(C(C(C(O3)CO)O)O)O)O)O.[Na+].[Na+]
• IUPAC Name: disodium;[[(2R,3S,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-oxidophosphoryl] [(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl] phosphate
• InChIKey: PKJQEQVCYGYYMM-QBNUFUENSA-L
• INCHI: 1S/C15H24N2O17P2.2Na/c18-3-5-8(20)10(22)12(24)14(32-5)33-36(28,29)34-35(26,27)30-4-6-9(21)11(23)13(31-6)17-2-1-7(19)16-15(17)25;;/h1-2,5-6,8-14,18,20-24H,3-4H2,(H,26,27)(H,28,29)(H,16,19,25);;/q;2*+1/p-2/t5-,6-,8-,9-,10+,11-,12-,13-,14-;;/m1../s1
• Isomeric SMILES: C1=CN(C(=O)NC1=O)[C@H]2[C@@H]([C@@H]([C@H](O2)COP(=O)([O-])OP(=O)([O-])O[C@@H]3[C@@H]([C@H]([C@@H]([C@H](O3)CO)O)O)O)O)O.[Na+].[Na+]
• Alternate CAS: 117756-22-6
• PubChem CID: 119803
• Molecular Weight: 610.27

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Nucleosides, nucleotides, and analogues
    • Class Pyrimidine nucleotides
      • Subclass Pyrimidine nucleotide sugars

• Kingdom: Organic compounds
• Superclass: Nucleosides, nucleotides, and analogues
• Class: Pyrimidine nucleotides
• Subclass: Pyrimidine nucleotide sugars
• Intermediate Tree Nodes: Not available
• Direct Parent: Pyrimidine nucleotide sugars
• Alternative Parents: Pyrimidine ribonucleoside diphosphates Pentose phosphates Glycosylamines Monosaccharide phosphates Organic pyrophosphates Pyrimidones Alkyl phosphates Hydropyrimidines Oxanes Vinylogous amides Tetrahydrofurans Heteroaromatic compounds Ureas Secondary alcohols Lactams Oxacyclic compounds Azacyclic compounds Polyols Organic oxides Hydrocarbon derivatives Primary alcohols Organopnictogen compounds Organic sodium salts Organonitrogen compounds
• Molecular Framework: Aromatic heteromonocyclic compounds
• Substituents: Pyrimidine nucleotide sugar - Pyrimidine ribonucleoside diphosphate - Pentose phosphate - Pentose-5-phosphate - Glycosyl compound - N-glycosyl compound - Monosaccharide phosphate - Organic pyrophosphate - Pyrimidone - Hydropyrimidine - Monosaccharide - Organic phosphoric acid derivative - Oxane - Phosphoric acid ester - Pyrimidine - Alkyl phosphate - Vinylogous amide - Heteroaromatic compound - Tetrahydrofuran - Secondary alcohol - Lactam - Urea - Organoheterocyclic compound - Organic alkali metal salt - Azacycle - Oxacycle - Polyol - Organooxygen compound - Organonitrogen compound - Organic nitrogen compound - Organic sodium salt - Primary alcohol - Hydrocarbon derivative - Organic oxygen compound - Organopnictogen compound - Organic oxide - Organic salt - Alcohol - Aromatic heteromonocyclic compound
• Description: This compound belongs to the class of organic compounds known as pyrimidine nucleotide sugars. These are pyrimidine nucleotides bound to a saccharide derivative through the terminal phosphate group.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Associated Targets(Human)

ABL1 Tclin Tyrosine-protein kinase ABL (18331 Activities)

Discover Target: ABL1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

ADRB2 Tclin Beta-2 adrenergic receptor (11824 Activities)

Discover Target: ADRB2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

ADRA2A Tclin Alpha-2a adrenergic receptor (9450 Activities)

Discover Target: ADRA2A

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

AGTR1 Tclin Type-1 angiotensin II receptor (5176 Activities)

Discover Target: AGTR1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

GSK3B Tclin Glycogen synthase kinase-3 beta (11785 Activities)

Discover Target: GSK3B

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CSNK1D Tchem Casein kinase I delta (4546 Activities)

Discover Target: CSNK1D

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

S1PR1 Tclin Sphingosine 1-phosphate receptor Edg-1 (5806 Activities)

Discover Target: S1PR1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CDK2 Tchem Cyclin-dependent kinase 2 (9050 Activities)

Discover Target: CDK2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

GLP1R Tclin Glucagon-like peptide 1 receptor (111429 Activities)

Discover Target: GLP1R

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

C5AR1 Tclin C5a anaphylatoxin chemotactic receptor (2677 Activities)

Discover Target: C5AR1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

AURKA Tchem Serine/threonine-protein kinase Aurora-A (10240 Activities)

Discover Target: AURKA

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

U2OS (164939 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CX3CR1 Tchem C-X3-C chemokine receptor 1 (1686 Activities)

Discover Target: CX3CR1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

FPR2 Tchem Lipoxin A4 receptor (3472 Activities)

Discover Target: FPR2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

FFAR4 Tchem G-protein coupled receptor 120 (2999 Activities)

Discover Target: FFAR4

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

BRD4 Tchem Bromodomain-containing protein 4 (13122 Activities)

Discover Target: BRD4

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

GPR35 Tchem G-protein coupled receptor 35 (2643 Activities)

Discover Target: GPR35

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

TRIM24 Tchem Transcription intermediary factor 1-alpha (2087 Activities)

Discover Target: TRIM24

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

BRPF1 Tchem Peregrin (2217 Activities)

Discover Target: BRPF1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

HEK-293T (167025 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

Aplnr Apelin receptor (201 Activities)

Discover Target: Aplnr

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mapk1 MAP kinase ERK2 (650 Activities)

Discover Target: Mapk1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Fgfr3 Fibroblast growth factor receptor 3 (21 Activities)

Discover Target: Fgfr3

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Gpr119 Glucose-dependent insulinotropic receptor (270 Activities)

Discover Target: Gpr119

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Chemical and Physical Properties

• Molecular Weight: 610.270 g/mol
• Hydrogen Bond Donor Count: 7
• Hydrogen Bond Acceptor Count: 17
• Rotatable Bond Count: 9
• Exact Mass: 610.019 Da
• Monoisotopic Mass: 610.019 Da
• Topological Polar Surface Area: 297.000 Ų
• Heavy Atom Count: 38
• Formal Charge: 0
• Complexity: 948.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 9
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 3

XLogP3

References

1. Xuqiu He, Ronghao Huang, Lipeng Liu, Yingying Li, Wenzhao Wang, Qingshan Xu, Youben Yu, Tianshan Zhou.  (2021)  CsUGT78A15 catalyzes the anthocyanidin 3-O-galactoside biosynthesis in tea plants.  PLANT PHYSIOLOGY AND BIOCHEMISTRY,      [PMID:34217130] [10.1016/j.plaphy.2021.06.029]

2. Cao Shiyang, Wang Tong, Ren Yifan, Wu Gengshan, Zhang Yuan, Tan Yafang, Zhou Yazhou, Chen Hongyan, Zhang Yu, Song Yajun, Yang Ruifu, Du Zongmin.  (2024)  A protein O-GlcNAc glycosyltransferase regulates the antioxidative response in Yersinia pestis.  Nature Communications,  15  (1): (1-16).  [PMID:39152136] [10.1038/s41467-024-50959-w]

3. Lin Ge, Yu Xia, Wenxin Xu, Ruobing Jia, Tingting Zhang.  (2025)  Efficient Biosynthesis of Gastrodin by UDP-Glycosyltransferase from Rauvolfia serpentina.  JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY,      [PMID:40147927] [10.4014/jmb.2501.01002]

4. Yang Gu, Yaru Jiang, Changfan Li, Jiang Zhu, Xueyao Lu, Jianyue Ge, Mengchen Hu, Jieying Deng, Jingbo Ma, Zhiliang Yang, Xiaoman Sun, Feng Xue, Guocheng Du, Peng Xu, He Huang.  (2024)  High titer production of gastrodin enabled by systematic refactoring of yeast genome and an antisense-transcriptional regulation toolkit.  METABOLIC ENGINEERING,      [PMID:38428728] [10.1016/j.ymben.2024.02.016]

5. Xiaomeng Zhang, Xinquan Tian, Junyu Luo, Xiaoyang Wang, Shoupu He, Gaofei Sun, Ruidan Dong, Panhong Dai, Xiao Wang, Zhaoe Pan, Baojun Chen, Daowu Hu, Liru Wang, Baoyin Pang, Aishuang Xing, Guoyong Fu, Baoquan Wang, Jinjie Cui, Lei Ma, Xiongming Du.  (2025)  Identification of UDP-glucosyltransferase involved in the biosynthesis of phloridzin in Gossypium hirsutum.  PLANT JOURNAL,  121  (3): (e17248).  [PMID:39935137] [10.1111/tpj.17248]

6. Chen-Xin Guo, Jiyan Li, Yu Wang, Tang Li, Heng Yin.  (2025)  Functional characterization of a Stevia rebaudiana flavonoid glycosyltransferase.  ENZYME AND MICROBIAL TECHNOLOGY,      [PMID:40639146] [10.1016/j.enzmictec.2025.110708]

7. Yan Sun, Tayyab Shaheen, Jiali Guo, Bingjie Shi, Miaohan Li, Xiaoyan Li, Yongqiang Li, Gunghui Tang.  (2025)  Laboratory selection, resistance risk assessment, fitness costs and biochemical mechanism of Aphis gossypii to flonicamid.  PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY,      [PMID:41326073] [10.1016/j.pestbp.2025.106757]

8. Shuocheng She, Jiachen Zuo, Yang Li, Liu Sun, Yaowei Dai, Zekun Yang, Jinwu Zhao, Lei Wang, Wenxia Wang, Pandeng Hou, Qiuhong Qu, Yizhu Zhang, Mingxia He.  (2026)  Terahertz Metasurface with Ultrastrong Hotspots Empowered by QBIC.  ANALYTICAL CHEMISTRY,      [PMID:41534007] [10.1021/acs.analchem.5c06405]