YIL781 hydrochloride - Moligand™, ≥99% , CAS No.875258-85-8(free base)

CAS: 875258-85-8(free base) Cat. No.: Y275486 Molecular Weight: 409.50(free base)

GRADE & PURITY Moligand™, ≥99%

Synonyms

6-(4-Fluorophenoxy)-2-methyl-3-[[(3S)-1-(1-methylethyl)-3-piperidinyl]methyl]-4(3H)-quinazolinone hydrochloride | (S)-6-(4-fluorophenoxy)-3-((1-isopropylpiperidin-3-yl)methyl)-2-methylquinazolin-4(3H)-one hydrochloride

Storage

Room temperature,Desiccated

Shipped In

Normal

Overview

Application：

YIL-781 has been used as a ghrelin receptor (GHSR) antagonist in combination with methanandamide (mAEA) to study its effect on gastric vagal afferent mechanosensitivity；

Specifications

Synonyms

6-(4-Fluorophenoxy)-2-methyl-3-[[(3S)-1-(1-methylethyl)-3-piperidinyl]methyl]-4(3H)-quinazolinone hydrochloride | (S)-6-(4-fluorophenoxy)-3-((1-isopropylpiperidin-3-yl)methyl)-2-methylquinazolin-4(3H)-one hydrochloride

Specifications & Purity

Moligand™, ≥99%

Biochemical and Physiological Mechanisms

Ghrelin receptor (GHS-R1a) antagonist (K i = 17 nM). Competitive antagonist activity in vitro (pK B = 7.54). Displays no affinity for the motilin receptor (K i = 6 μM).

Storage

Room temperature, Desiccated

Shipped In

Normal

Grade

Moligand™

Note

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Purity

≥99%

Names and Identifiers

• Pubchem Sid: 488200360
• Pubchem Sid Url: https://pubchem.ncbi.nlm.nih.gov/substance/488200360
• Molecular Weight: 409.50(free base)

Associated Targets(Human)

GHSR Tclin Growth hormone secretagogue receptor type 1 (2 Activities)

Discover Target: GHSR

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

KCNH2 Tclin Potassium voltage-gated channel subfamily H member 2 (2 Activities)

Discover Target: KCNH2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Chemical and Physical Properties

• Solubility: Soluble in DMSO to 100 mM and in ethanol to 100 mM