Z-VDVAD-FMK - ≥98% , CAS No.210344-92-6

CAS: 210344-92-6 Cat. No.: Z648095 Molecular Weight: 695.73 PubChem CID: 44135215

GRADE & PURITY ≥98%

Synonyms

Cbz-DL-Val-DL-Asp(OMe)-DL-Val-DL-Ala-DL-Asp(OMe)-CH2F | PD118671 | DTXSID20657590 | Methyl 17-(fluoroacetyl)-8-(2-methoxy-2-oxoethyl)-14-methyl-3,6,9,12,15-pentaoxo-1-phenyl-5,11-di(propan-2-yl)-2-oxa-4,7,10,13,16-pentaazanonadecan-19-oate (non-preferred

Storage

Desiccated,Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

Z-VDVAD-FMK is a special inhibitor of caspase-2 . Z-VDVAD-FMK produces a reduction in Lovastatin-induced apoptosis

In Vitro

Cotreatment of cells with the caspase inhibitors Ac-DEVD-CHO, Z-VDVAD-FMK (100 μM), Z-IETD-fmk, and Z-LEHD-fmk alone or in combination, or overexpression of CrmA, prevents many morphological features of apoptosis but not loss of mitochondrial membrane potential (DCm), phospatidilserine exposure, and cell death. Z-VDVAD-FMK (2 μM) greatly inhibits the Rho-kinase activity in HMEC-1 cells stimulated by Thrombin and displays no effect on control cells. Z-VDVAD-FMK (zVDVAD-fmk) produces a reduction in Lovastatin-induced apoptosis. Z-VDVAD-FMK (100 μM) significantly reduces Lovastatin-induced loss of DNA by 19.1±8.3%. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Viability AssayCell Line: The human T-cell leukemia Jurkat (Clone E6.1, ATCC TIB-152) Concentration: 100 μM Incubation Time: 22 hours Result: Prevented Doxorubicin (1 μM)-induced nuclear apoptosis, but not cell death.

Form:Solid

IC50& Target:Caspase-2

Specifications

Synonyms

Cbz-DL-Val-DL-Asp(OMe)-DL-Val-DL-Ala-DL-Asp(OMe)-CH2F | PD118671 | DTXSID20657590 | Methyl 17-(fluoroacetyl)-8-(2-methoxy-2-oxoethyl)-14-methyl-3, 6, 9, 12, 15-pentaoxo-1-phenyl-5, 11-di(propan-2-yl)-2-oxa-4, 7, 10, 13, 16-pentaazanonadecan-19-oate (non-preferred

Specifications & Purity

≥98%

Biochemical and Physiological Mechanisms

Z-VDVAD-FMK is a special inhibitor of caspase-2 . Z-VDVAD-FMK produces a reduction in Lovastatin-induced apoptosis.

Storage

Desiccated, Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Purity

≥98%

Names and Identifiers

• Canonical Smiles: CC(C)C(C(=O)NC(C)C(=O)NC(CC(=O)OC)C(=O)CF)NC(=O)C(CC(=O)OC)NC(=O)C(C(C)C)NC(=O)OCC1=CC=CC=C1
• IUPAC Name: methyl 5-fluoro-3-[2-[[2-[[4-methoxy-2-[[3-methyl-2-(phenylmethoxycarbonylamino)butanoyl]amino]-4-oxobutanoyl]amino]-3-methylbutanoyl]amino]propanoylamino]-4-oxopentanoate
• InChIKey: ANTIWMNLIROOQF-UHFFFAOYSA-N
• INCHI: 1S/C32H46FN5O11/c1-17(2)26(30(44)34-19(5)28(42)35-21(23(39)15-33)13-24(40)47-6)37-29(43)22(14-25(41)48-7)36-31(45)27(18(3)4)38-32(46)49-16-20-11-9-8-10-12-20/h8-12,17-19,21-22,26-27H,13-16H2,1-7H3,(H,34,44)(H,35,42)(H,36,45)(H,37,43)(H,38,46)
• Isomeric SMILES: CC(C)C(C(=O)NC(C)C(=O)NC(CC(=O)OC)C(=O)CF)NC(=O)C(CC(=O)OC)NC(=O)C(C(C)C)NC(=O)OCC1=CC=CC=C1
• Alternate CAS: 210344-92-6
• PubChem CID: 44135215
• Molecular Weight: 695.73

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organic acids and derivatives
    • Class Peptidomimetics
      • Subclass Hybrid peptides

• Kingdom: Organic compounds
• Superclass: Organic acids and derivatives
• Class: Peptidomimetics
• Subclass: Hybrid peptides
• Intermediate Tree Nodes: Not available
• Direct Parent: Hybrid peptides
• Alternative Parents: Aspartic acid and derivatives Valine and derivatives N-acyl-alpha amino acids and derivatives Alpha amino acid amides Alanine and derivatives Beta amino acids and derivatives Benzyloxycarbonyls Gamma-keto acids and derivatives Fatty acid methyl esters N-acyl amines Dicarboxylic acids and derivatives Alpha-haloketones Methyl esters Carbamate esters Secondary carboxylic acid amides Organic carbonic acids and derivatives Hydrocarbon derivatives Organic oxides Organofluorides Organonitrogen compounds Alkyl fluorides Organopnictogen compounds
• Molecular Framework: Aromatic homomonocyclic compounds
• Substituents: Hybrid peptide - Aspartic acid or derivatives - Valine or derivatives - N-acyl-alpha amino acid or derivatives - Alpha-amino acid amide - Beta amino acid or derivatives - Alanine or derivatives - N-substituted-alpha-amino acid - Alpha-amino acid or derivatives - Benzyloxycarbonyl - Gamma-keto acid - Fatty acid ester - Fatty acid methyl ester - Monocyclic benzene moiety - Dicarboxylic acid or derivatives - Fatty amide - Fatty acyl - Benzenoid - Keto acid - N-acyl-amine - Methyl ester - Carbamic acid ester - Alpha-haloketone - Ketone - Secondary carboxylic acid amide - Carbonic acid derivative - Carboxamide group - Carboxylic acid ester - Carboxylic acid derivative - Alkyl fluoride - Alkyl halide - Hydrocarbon derivative - Organic nitrogen compound - Carbonyl group - Organic oxide - Organopnictogen compound - Organic oxygen compound - Organohalogen compound - Organofluoride - Organonitrogen compound - Organooxygen compound - Aromatic homomonocyclic compound
• Description: This compound belongs to the class of organic compounds known as hybrid peptides. These are compounds containing at least two different types of amino acids (alpha, beta, gamma, delta) linked to each other through a peptide bond.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y