7-BIA - 10mM in DMSO , CAS No.1313403-49-4

CAS: 1313403-49-4 Cat. No.: B654741 Molecular Weight: 294.30 PubChem CID: 137321149

GRADE & PURITY 10mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

7-BIA is a receptor-type protein tyrosine phosphatase D (PTPRD) inhibitor with an IC 50 of ~1-3 μM

In Vitro

7-BIA (7-butoxy illudalic acid analog) inhibits recombinant human PTPRD and recombinant human PTPRS with IC 50 values of ~1–3 μM and 40 μM, respectively. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

7-BIA (10-20 mg/kg; given i.p.; only once) reduces cocaine self-administration in highly experienced WT mice . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: WT mice (available cocaine 50 times, 1 mg/kg infusions on FR1 schedule during ≥20 prior sessions) Dosage: 10 mg/kg, 20 mg/kg Administration: Given i.p.; only once Result: Reduced cocaine self-administration in highly experienced WT mice.

IC50& Target:IC50: ~1-3 μM (PTPRD), 40 μM (PTPRS)

Specifications

Specifications & Purity

10mM in DMSO

Biochemical and Physiological Mechanisms

7-BIA is a receptor-type protein tyrosine phosphatase D (PTPRD) inhibitor with an IC 50 of ~1-3 μM.

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Action Type

INHIBITOR

Names and Identifiers

• PubChem CID: 137321149
• Molecular Weight: 294.30