≥95% for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Store at -20°C Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
7BIO is a 3′ substituted kinase inhibitory bis-indole, which functions as a caspase independent nonapoptotic cell death inducer. Interestingly 7BIO did not inhibit the activity of CDKs and GSK-3, which is the target of many other kinase inhibitory bis-indoles. In addition, research suggests that kinase inhibitory bis-indoles, also known as indirubins, do not inhibit CDK and GSK-3 when there are substitutions on position 7 via steric hinderance. Alternate studies indicate that 7BIO can greatly reduce mitochondrial transmembrane potential. Furthermore, 7BIO causes the dilation of the Endoplasmic Reticulum and acute cytoplasmic destruction which isolated nuclei with DNA fully intact. 7BIO is also a potent inhibitor of Aurora kinase B and C.
| Pubchem Sid | 504773302 |
|---|---|
| Pubchem Sid Url | https://pubchem.ncbi.nlm.nih.gov/substance/504773302 |
| Canonical Smiles | C1=CC=C2C(=C1)C(=C(N2)C3=C(NC4=C3C=CC=C4Br)O)N=O |
| IUPAC Name | 7-bromo-3-(3-nitroso-1H-indol-2-yl)-1H-indol-2-ol |
| InChIKey | HYMACPDEJIEMST-UHFFFAOYSA-N |
| INCHI | 1S/C16H10BrN3O2/c17-10-6-3-5-9-12(16(21)19-13(9)10)15-14(20-22)8-4-1-2-7-11(8)18-15/h1-7,18-19,21H |
| Isomeric SMILES | C1=CC=C2C(=C1)C(=C(N2)C3=C(NC4=C3C=CC=C4Br)O)N=O |
| PubChem CID | 135423792 |
| Molecular Weight | 356.17 |
Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS →Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA →Full quality attributes and acceptance criteria for this grade.
View spec sheet →Taxonomy Tree
| Kingdom | Organic compounds |
|---|---|
| Superclass | Organoheterocyclic compounds |
| Class | Indoles and derivatives |
| Subclass | Hydroxyindoles |
| Intermediate Tree Nodes | Not available |
| Direct Parent | Hydroxyindoles |
| Alternative Parents | Indoles Substituted pyrroles Benzenoids Aryl bromides Heteroaromatic compounds C-nitroso compounds Azacyclic compounds Organooxygen compounds Organobromides Organic oxides Hydrocarbon derivatives Organic anions |
| Molecular Framework | Aromatic heteropolycyclic compounds |
| Substituents | Hydroxyindole - Indole - Aryl bromide - Aryl halide - Benzenoid - Substituted pyrrole - Heteroaromatic compound - Pyrrole - Organic nitroso compound - C-nitroso compound - Azacycle - Organic nitrogen compound - Organic oxygen compound - Organooxygen compound - Organonitrogen compound - Organobromide - Organohalogen compound - Hydrocarbon derivative - Organic oxide - Organic anion - Aromatic heteropolycyclic compound |
| Description | This compound belongs to the class of organic compounds known as hydroxyindoles. These are organic compounds containing an indole moiety that carries a hydroxyl group. |
| External Descriptors | Not available |
Find and download the COA for your product by matching the lot number on the packaging.
| Lot Number | Certificate Type | Date | Item |
|---|---|---|---|
 I2222545 | Certificate of Analysis | Jul 10, 2025 | B338496 |
| I2222546 | Certificate of Analysis | Jul 10, 2025 | B338496 |
| I2222547 | Certificate of Analysis | Jul 10, 2025 | B338496 |
| I2222552 | Certificate of Analysis | Jul 10, 2025 | B338496 |
| I2222656 | Certificate of Analysis | Jul 10, 2025 | B338496 |
| I2222670 | Certificate of Analysis | Jul 10, 2025 | B338496 |
| L2405145 | Certificate of Analysis | Jun 21, 2022 | B338496 |
| Solubility | Soluble in DMSO |
|---|---|
| Molecular Weight | 356.170 g/mol |
| XLogP3 | 3.900 |
| Hydrogen Bond Donor Count | 3 |
| Hydrogen Bond Acceptor Count | 3 |
| Rotatable Bond Count | 1 |
| Exact Mass | 354.996 Da |
| Monoisotopic Mass | 354.996 Da |
| Topological Polar Surface Area | 81.200 Ų |
| Heavy Atom Count | 22 |
| Formal Charge | 0 |
| Complexity | 438.000 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| The total count of all stereochemical bonds | 0 |
| Covalently-Bonded Unit Count | 1 |
