Moligand™, 10 mM in Water Moligand™ for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Store at -80°C Ships Dry ice packs + Cold packs Check lot-specific COA for exact specifications.
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Cited in 19 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Alendronic acid, a bisphosphonate, is a farnesyl diphosphate synthase (FDPS) inhibitor. Alendronic acid inhibits osteoclast-mediated bone resorption. Alendronic acid shows efficacy in postmenopausal osteoporosis, malignant hypercalcemia and Paget’s disease.
| Isomeric SMILES | C(CC(O)(P(=O)(O)O)P(=O)(O)O)CN |
|---|---|
| RTECS | SZ6521833 |
| Alternate CAS | 121268-17-5 |
| Molecular Weight | 249.1 |
| Reaxy-Rn | 2275403 |
| Reaxys-RN_link_address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=2275403&ln= |
Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS →Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA →Full quality attributes and acceptance criteria for this grade.
View spec sheet →| Melt Point(°C) | 235°C(dec.)(lit.) |
|---|
| 1. Wenhui Wang, Xinyu Zeng, Zhiliang Gao, Linqiang Mei, Chang Pan, Jie Li, Yuguo Chen. (2025) A polymer-based “immunogenic cell death” amplifier promotes systemic breast cancer inhibition through combined mitochondrial oxidative stress and calcium overload. CHEMICAL ENGINEERING JOURNAL, [PMID:] [10.1016/j.cej.2025.165725] |
| 2. Wentao Shi, Yan Gao, Yiqing Wu, Jiaqi Sun, Bai Xu, Xiaojie Lu, Qing Wang. (2023) A multifunctional polydopamine/genipin/alendronate nanoparticle licences fibrin hydrogels osteoinductive and immunomodulatory potencies for repairing bone defects. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, [PMID:37524274] [10.1016/j.ijbiomac.2023.126072] |
| 3. Yan Huang, Maowen Chen, Yiding Shen, Xinkun Shen, Menghuan Li, Yanan Li, Yuan Liu, Kaiyong Cai, Zhong Luo, Yan Hu. (2023) Bone-targeting cell membrane-engineered CaCO3-based nanoparticles restore local bone homeostasis for microenvironment-responsive osteoporosis treatment. CHEMICAL ENGINEERING JOURNAL, [PMID:] [10.1016/j.cej.2023.144145] |
| 4. Yonghui Wu, Lu Yang, Qianqian Wu, Qingshan Liu, Ling Zou, Xiaochao Yang, Keyong Tang. (2023) Regulation of the Oxidase Mimetic Activity of Ceria Nanoparticles by Buffer Composition. CHEMISTRY-A EUROPEAN JOURNAL, 29 (29): (e202204071). [PMID:36879435] [10.1002/chem.202204071] |
| 5. Yimin Niu, Hongbin Yang, Zhenyan Yu, Cuicui Gao, Shuaishuai Ji, Jie Yan, Lei Han, Qiang Huo, Ming Xu, Yang Liu. (2022) Intervention with the Bone-Associated Tumor Vicious Cycle through Dual-Protein Therapeutics for Treatment of Skeletal-Related Events and Bone Metastases. ACS Nano, [PMID:35077154] [10.1021/acsnano.1c08269] |
| 6. Shan Zhang, Ruiqi Liang, Kun Xu, Shurong Zheng, Somnath Mukherjee, Peng Liu, Changhao Wang, Yashao Chen. (2021) Construction of multifunctional micro-patterned PALNMA/PDADMAC/PEGDA hydrogel and intelligently responsive antibacterial coating HA/BBR on Mg alloy surface for orthopedic application. Materials Science & Engineering C-Materials for Biological Applications, [PMID:35148866] [10.1016/j.msec.2021.112636] |
| 7. Zhenyu Zhao, Gen Li, Huitong Ruan, Keyi Chen, Zhengwei Cai, Guanghua Lu, Runmin Li, Lianfu Deng, Ming Cai, Wenguo Cui. (2021) Capturing Magnesium Ions via Microfluidic Hydrogel Microspheres for Promoting Cancellous Bone Regeneration. ACS Nano, [PMID:34342981] [10.1021/acsnano.1c02147] |
| 8. Lei Chen, Yufei Tang, Kang Zhao, Xiang Zha, Min Wei, Quanchang Tan, Zixiang Wu. (2020) Sequential release of double drug (graded distribution) loaded gelatin microspheres/PMMA bone cement. Journal of Materials Chemistry B, 9 (2): (508-522). [PMID:33305784] [10.1039/D0TB01452D] |
| 9. Xiaonan Zhang, Kang Chen, Bo Wei, Xingwang Liu, Zeming Lei, Xizhuang Bai. (2016) Ginsenosides Rg3 attenuates glucocorticoid-induced osteoporosis through regulating BMP-2/BMPR1A/Runx2 signaling pathway. CHEMICO-BIOLOGICAL INTERACTIONS, [PMID:27387537] [10.1016/j.cbi.2016.07.003] |
| 10. Hong Gao, Chen Wang, Wenqi Zhang, Guowei Shan, Weixing Li. (2025) Alendronic acid/Cu-MOF-74 nanorods arrayed interlayer regulated nanofiltration membrane to separate glutathione from amino acids. SEPARATION AND PURIFICATION TECHNOLOGY, [PMID:] [10.1016/j.seppur.2025.132291] |
| 11. Yu Chen, Qi-Wen Chen, Fang-Sheng Fu, Hui-Yun Gu, Aixi Yu, Xian-Zheng Zhang. (2024) Bone Destruction-Chemotactic Osteoprogenitor Cells Deliver Liposome Nanomedicines for the Treatment of Osteosarcoma and Osteoporosis. ACS Nano, [PMID:39424791] [10.1021/acsnano.4c10053] |
| 12. Han Lu, Song Yaqi, Chen Min, Pan Leiqing, Tu Kang, Su Jing. (2025) Development of a PCR fluorescence sensor utilizing an upconversion FRET system for rapid and ultra-sensitive determination of Escherichia coli. MICROCHIMICA ACTA, 192 (4): (1-11). [PMID:40053209] [10.1007/s00604-025-07077-1] |
| 13. Wu-Shang Yang, Ze-Lin Qiu, Wen-Han Yu, Li-Feng Fang, Bao-Ku Zhu. (2024) Integrating binary organic phosphonic acid into nanofiltration membrane for high precision separation of mono-/divalent anions. SEPARATION AND PURIFICATION TECHNOLOGY, [PMID:] [10.1016/j.seppur.2024.126287] |
| 14. Chunting He, Penghui He, Yangsen Ou, Xue Tang, Hongjiao Wei, Yanhua Xu, Shuting Bai, Zhaofei Guo, Rui Hu, Kun Xiong, Guangsheng Du, Xun Sun. (2025) Rectifying the Crosstalk between the Skeletal and Immune Systems Improves Osteoporosis Treatment by Core–Shell Nanocapsules. ACS Nano, [PMID:39879106] [10.1021/acsnano.4c14728] |
| 15. Yayu Wang, Jie Yao, Lizhao Cai, Tong Liu, Xiaogang Wang, Ye Zhang, Zhiying Zhou, Tingwei Li, Minyi Liu, Renfa Lai, Xiangning Liu. (2023) Bone-Targeted Extracellular Vesicles from Mesenchymal Stem Cells for Osteoporosis Therapy. International Journal of Nanomedicine, [PMID:33116512] [10.2147/IJN.S263756] |
| 16. Pei-Jie Zhang, Dong Zhou, Zi-Wei Yang, Yong-Guo Hu, Meng-Wen Ma, Jin-Xuan Fan, Yuan-Di Zhao, Jia-Hua Zou. (2025) Salmonella-Derived Fluorescent Carbon Dots for Reprogramming Tumor-Associated Macrophages and Enhancing Tumor Photodynamic Therapy. ACS Applied Bio Materials, [PMID:40411829] [10.1021/acsabm.5c00624] |
| 17. Xiaoming Li, Shuang Yang, Shidan Li, Pengfei Wu, Wenhui Hu, Wei Dai, Jingru Xie, Jinlong Qiu, Liang Zhang, Hui Zhao, Shiwu Dong. (2025) Reverse biogradient biomimetic periosteum with osteogenic and angiogenic characteristics for bone regeneration. Materials Today Bio, [PMID:40585030] [10.1016/j.mtbio.2025.101967] |
| 18. Xuanzuo JIANG, Feifei Feng, Wenyuan JIA, Yuheng YANG, Yongzheng YAN, Zhiqiang CHENG, Yungang LUO, Ji QU, Guomin LIU. (2025) Treatment of osteoporotic bone defects with carboxymethyl chitosan based biomimetic mineralized hydrogel loaded with icaritin. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, [PMID:41260430] [10.1016/j.ijbiomac.2025.149089] |
| 19. Yiyi Yu, Xin Sun, Xiaokun Yue, Huyue Zhang, Shuo Chen, Guang Yang, Qian Luo, Chuanglong He, Xiaojun Zhou. (2026) Programmed regulation of microenvironment remodeling and bone regeneration for bone repair by coaxial hydrogel scaffold with ultrasound-activated drug delivery. Materials Today Bio, [PMID:] [10.1016/j.mtbio.2026.102988] |
Our grade selection guide covers purity, stabilizer status, and application suitability for all variants in our catalog.
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