Alsterpaullone, 2-Cyanoethyl - Moligand™, ≥97% , Inhibitor of cyclin dependent kinase 1;Inhibitor of glycogen synthase kinase 3 beta, Inhibitor of cyclin dependent kinase 1;Inhibitor of glycogen synthase kinase 3 beta

Cat. No.: A336672

GRADE & PURITY Moligand™, ≥97%

Synonyms

Alsterpaullone, 2-Cyanoethyl is also known as 3-(6-Oxo-9-nitro-5,6,7,12-tetrahydroindolo[3,2-d][1]benzazepin-2-yl)propionitrile.

Storage

Store at 2-8°C

Shipped In

Wet ice

Overview

Alsterpaullone, 2-Cyanoethyl is an alsterpaullone derivative that acts as a highly potent, ATP-competitive, selective inhibitor of Cdk1/cyclin B and GSK-3β (IC50 = 230 pM and 800 pM, respectively; [ATP] = 15 μM). Alsterpaullone, 2-Cyanoethyl displays ~37-fold greater selectivity for Cdk1/cyclin B over Cdk5/p25 (IC50 = 30 nM). In a commercially available testing screen panel, Alsterpaullone, 2-Cyanoethyl was shown to inhibit other kinases (pIC50 = -logIC50[M]; pIC50 ~ 7.5, 7.0, 7.0, 6.5, 6.5, 6.0, and 6.0 for Cdk2/A, Cdk4/D1, GSK-3β, PDGFRβ, Src, VEGFR-2, and VEGFR-3, respectively; [ATP] = 1 μM).

Specifications

Synonyms

Alsterpaullone, 2-Cyanoethyl is also known as 3-(6-Oxo-9-nitro-5, 6, 7, 12-tetrahydroindolo[3, 2-d][1]benzazepin-2-yl)propionitrile.

Specifications & Purity

Moligand™, ≥97%

Storage

Store at 2-8°C

Shipped In

Wet ice

This product requires cold chain shipping. Ground and other economy services are not available.

Grade

Moligand™

Action Type

INHIBITOR

Mechanism of action

Inhibitor of cyclin dependent kinase 1;Inhibitor of glycogen synthase kinase 3 beta

Purity

≥97%

Associated Targets(Human)

CDK1 Tchem Cyclin-dependent kinase 1 (1 Activities)

Discover Target: CDK1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

GSK3B Tclin Glycogen synthase kinase-3 beta (2 Activities)

Discover Target: GSK3B

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Chemical and Physical Properties

• Solubility: Soluble in DMSO.