Amfebutamone (Bupropion) HCl - 10mM in DMSO , Norepinephrine transporter inhibitor, CAS No.31677-93-7, Norepinephrine transporter inhibitor

CAS: 31677-93-7 Cat. No.: A409254 Molecular Weight: 276.2 EC Number: 250-759-9

GRADE & PURITY 10mM in DMSO

Synonyms

1-​(3-​chlorophenyl)​-​2-​[(1,​1-​dimethylethyl)​amino]​-1-​propanone,hydrochloride (1:1)

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

Information

Amfebutamone (Bupropion) HCl is a selective norepinephrine-dopamine reuptake inhibitor with IC50 of 6.5 and 3.4 μM for the reuptake of dopamine and norepinephrine, respectively.
In vitro

In vivo

Cell Data

cell lines：

Concentrations：

Incubation Time：

Powder Purity:≥99%

Specifications

Synonyms

1-​(3-​chlorophenyl)​-​2-​[(1, ​1-​dimethylethyl)​amino]​-1-​propanone, hydrochloride (1:1)

Specifications & Purity

10mM in DMSO

Biochemical and Physiological Mechanisms

Amfebutamone (Bupropion) HCl is a selective norepinephrine-dopamine reuptake inhibitor with IC50 of 6.5 and 3.4 μM for the reuptake of dopamine and norepinephrine, respectively.

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Action Type

INHIBITOR

Mechanism of action

Norepinephrine transporter inhibitor

Names and Identifiers

• Isomeric SMILES: CC(C(=O)C1=CC(=CC=C1)Cl)NC(C)(C)C.Cl
• Alternate CAS: 34911-55-2
• Molecular Weight: 276.2
• Reaxy-Rn: 6161273
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=6161273&ln=

Chemical and Physical Properties

• Solubility: Solubility (25°C) In vitro DMSO: 36 mg/mL (200.36 mM); Water: 36 mg/mL (200.36 mM); Ethanol: 21 mg/mL (116.88 mM)
• Melt Point(°C): 233-234°C

References

1. Qiaoyuan Cheng, Linjun Shou, Cen Chen, Shi Shi, Minghao Zhou.  (2017)  Application of ultra-high-performance liquid chromatography coupled with LTQ-Orbitrap mass spectrometry for identification, confirmation and quantitation of illegal adulterated weight-loss drugs in plant dietary supplements.  JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES,      [PMID:28917128] [10.1016/j.jchromb.2017.09.009]

2. Sun Zhi, Wang Fangfang, Li Wenxuan, Ren Ruobing, Zhou Peipei, Jia Qingquan, Zhao Lingguo, Chen Di, Zuo Lihua.  (2024)  Pipette-tip solid-phase extraction coupled with matrix-assisted laser desorption/ionization mass spectrometry enables rapid and high-throughput analysis of antidepressants in rat serum.  ANALYTICAL AND BIOANALYTICAL CHEMISTRY,      [PMID:38997460] [10.1007/s00216-024-05439-x]