BAN ORL 24 - 10mM in DMSO , CAS No.1401463-54-4

CAS: 1401463-54-4 Cat. No.: B654527 Molecular Weight: 506.51

GRADE & PURITY 10mM in DMSO

Storage

Protected from light,Argon charged,Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

BAN ORL 24 is a nociceptin/orphanin FQ (N/OFQ) peptide receptor (NOP) antagonist. BAN ORL 24 has antagonistic effect for nociceptin (NOP) receptor with K I value of 0.24 nM in CHO cell. BAN ORL 24 can be used for the research of cancer and analgesic

In Vitro

BAN ORL 24 has antagonist for NOR and MOR (opioid receptor subtype) with IC 50 values of 50 μM and 0.224 μM, respectively. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

BAN ORL 24 (10 mg/kg; i.v.) attenuates the duration of BPRIM97 thermal antinociception. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: C57BL/6 miceDosage: 10 mg/kg Administration: 10 mg/kg; i.v. Result: Caused inhibition of BPRIM97-induced antinociception at 90-min postinjection. Did not attenuate BPR1M97-induced antinociception in the tail-clip test after 30 min.

IC50& Target:Ki: 0.24 nM (NOP in CHO cell),IC50: 50 μM (NOR),0.224 μM (MOR)

Specifications

Specifications & Purity

10mM in DMSO

Biochemical and Physiological Mechanisms

BAN ORL 24 is a nociceptin/orphanin FQ (N/OFQ) peptide receptor (NOP) antagonist. BAN ORL 24 has antagonistic effect for nociceptin (NOP) receptor with K I value of 0.24 nM in CHO cell. BAN ORL 24 can be used for the research of cancer and analgesic.

Storage

Protected from light, Argon charged, Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Action Type

ANTAGONIST

Names and Identifiers

• Isomeric SMILES: C1C[C@@H](N(C1)CC2=CC=CC=C2)C(=O)NCCCN3CCC4(CC3)C5=CC=CC=C5CO4.Cl.Cl
• Alternate CAS: 475150-69-7
• Molecular Weight: 506.51