BB-Cl-Amidine hydrochloride - ≥99% , CAS No.2436747-41-8

CAS: 2436747-41-8 Cat. No.: B650942 Molecular Weight: 496.43

GRADE & PURITY ≥99%

Storage

Store at 2-8°C,Desiccated

Shipped In

Wet ice

Overview

BB-Cl-Amidine hydrochloride is a peptidylarginine deminase (PAD) inhibitor

In Vivo

Treatment with BB-Cl-amidine subtly reduces splenomegaly in MRL/lpr mice, while there is a trend towards increased circulating levels of anti-NET antibodies with PAD inhibitor treatment. However, neither PAD inhibitor affected body weight or total IgG levels. Indeed, treatment with both Cl-amidine and BB-Cl-amidine significantly improves endothelium-dependent vasorelaxation. The BB-Cl-amidine group also shows a strong trend towards downregulation of IRGs. Treatment with either Cl-amidine or BB-Cl-amidine significantly improves muzzle alopecia, in many cases preventing it entirely . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: MRL/lpr mice . Dosage: 1 mg/kg. Administration: Subcutaneous injection daily from 8 to 14 weeks of age. Result: Significantly improved endothelium-dependent vasorelaxation and showed a strong trend towards downregulation of IRGs.

Form:Solid

IC50& Target:PAD

Specifications

Specifications & Purity

≥99%

Biochemical and Physiological Mechanisms

BB-Cl-Amidine hydrochloride is a peptidylarginine deminase (PAD) inhibitor.

Storage

Store at 2-8°C, Desiccated

Shipped In

Wet ice

This product requires cold chain shipping. Ground and other economy services are not available.

Action Type

INHIBITOR

Purity

≥99%

Names and Identifiers

• Molecular Weight: 496.43

Chemical and Physical Properties

• Solubility: DMSO : ≥ 100 mg/mL (201.44 mM) H2O : 1.3 mg/mL (2.62 mM; Need ultrasonic)