cGAMP sodium salt - ≥99% , CAS No.849214-04-6(freeacid)

CAS: 849214-04-6(freeacid) Cat. No.: C413869 Molecular Weight: 674.41 (free acid basis)

GRADE & PURITY ≥99%

Synonyms

3',3'-cGAMP

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Overview

Information

3',3'-cGAMP 3',3'-cGAMP (3',3'-cyclic GMP-AMP, Cyclic GMP-AMP, cGAMP) activates the endoplasmic reticulum (ER)-resident receptor stimulator of interferon genes (STING) , thereby inducing an antiviral state and the secretion of type I IFNs.

Targets

STING

In vivo

Sublingual immunization of mice with Bacillus anthracis protective antigen (PA) and the STING ligand 3′3′-cGAMP promotes PA-specific serum IgG Ab responses of the same magnitude as those induced after immunization with PA and the experimental adjuvants cholera toxin (CT). 3′3′-cGAMP also promotes serum anti-PA IgA and IgA-producing cells in the bone marrow. Furthermore, the saliva of mice immunized with 3′3′-cGAMP exhibits similar levels of PA-specific IgA Abs as groups immunized with CT as adjuvant. The adjuvant activity of 3′3′-cGAMP is associated with mixed Th1, Th2, and Th17 responses. 3′3′-cGAMP also induces rapid IFN-β and IL-10 responses in sublingual tissues and cervical lymph nodes, and TGF-β responses in the cervical lymph nodes, which can contribute to promoting IgA responses after sublingual immunization.

Product description

cGAMP (Cyclic GMP-AMPP) functions as an endogenous second messenger in metazoans and triggers interferon production in response to cytosolic DNA. cGAMP activates stimulator of interferon genes (STING), which activates a signaling cascade leading to the production of type I interferons and other immune mediators

Product application
cGAMP sodium salt has been used in cGAS-cGAMP Activity Assay

Specifications

Synonyms

3', 3'-cGAMP

Specifications & Purity

≥99%

Biochemical and Physiological Mechanisms

3', 3'-cGAMP (3', 3'-cyclic GMP-AMP, Cyclic GMP-AMP, cGAMP) activates the endoplasmic reticulum (ER)-resident receptor stimulator of interferon genes (STING), thereby inducing an antiviral state and the secretion of type I IFNs.

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Purity

≥99%

Names and Identifiers

• Molecular Weight: 674.41 (free acid basis)

Associated Targets(Human)

TMEM173 Tchem Stimulator of interferon genes protein (0 Activities)

Discover Target: TMEM173

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Chemical and Physical Properties

• Solubility: Solubility (25°C) In vitro Water: 100 mg/mL (148.72 mM); DMSO: 20 mg/mL (29.74 mM); Ethanol: Insoluble