CK869 - 10mM in DMSO , CAS No.388592-44-7

CAS: 388592-44-7 Cat. No.: C423796 Molecular Weight: 394.28 EC Number: 686-022-7

GRADE & PURITY 10mM in DMSO

Synonyms

HMS623C22 | CCG-33400 | 2-(3-Bromophenyl)-3-(2,4-dimethoxyphenyl)-4-thiazolidinone | D80737 | BS-17180 | EX-A2784 | SR-01000553731-1 | CK 869 | CK 869; CK869; CK-0157869; CK 0157869; CK0157869 | 2-(3-bromophenyl)-3-(2,4-dimethoxyphenyl)-1,3-thiazolidin-4-

Storage

Protected from light,Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

Product description

CK-869 is an Actin-Related Protein 2/3 (ARP2/3) complex inhibitor, with an IC50 of 7 μM.

Product Application

CK-869 has been used as an Arp2/3 complex inhibitor:

to treat cultured mammalian cells and study its in vitro and in vivo effects on microtubule assembly

to induce membrane blebbing in HT1080 fibrosarcoma cells

to treat KDM3A-null cells and study the relation between actin dynamics and ciliogenesis

Specifications

Synonyms

HMS623C22 | CCG-33400 | 2-(3-Bromophenyl)-3-(2, 4-dimethoxyphenyl)-4-thiazolidinone | D80737 | BS-17180 | EX-A2784 | SR-01000553731-1 | CK 869 | CK 869; CK869; CK-0157869; CK 0157869; CK0157869 | 2-(3-bromophenyl)-3-(2, 4-dimethoxyphenyl)-1, 3-thiazolidin-4-

Specifications & Purity

10mM in DMSO

Biochemical and Physiological Mechanisms

Inhibitor of human and bovine actin-related protein 2/3 (Arp2/3) complex. Inhibits actin polymerization with bovine Arp2/3 complex (IC 50 = 11 μM) and inhibits the formation of actin filament comet tails by Listeria monocytogenes in infected SKOV3 cells (

Storage

Protected from light, Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Action Type

INHIBITOR

Names and Identifiers

• Canonical Smiles: COC1=CC(=C(C=C1)N2C(SCC2=O)C3=CC(=CC=C3)Br)OC
• IUPAC Name: 2-(3-bromophenyl)-3-(2,4-dimethoxyphenyl)-1,3-thiazolidin-4-one
• InChIKey: MVWNPZYLNLATCH-UHFFFAOYSA-N
• INCHI: 1S/C17H16BrNO3S/c1-21-13-6-7-14(15(9-13)22-2)19-16(20)10-23-17(19)11-4-3-5-12(18)8-11/h3-9,17H,10H2,1-2H3
• Isomeric SMILES: COC1=CC(=C(C=C1)N2C(SCC2=O)C3=CC(=CC=C3)Br)OC
• WGK Germany: 3
• Molecular Weight: 394.28
• Reaxy-Rn: 19720233
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=19720233&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Benzenoids
    • Class Benzene and substituted derivatives
      • Subclass Methoxybenzenes

• Kingdom: Organic compounds
• Superclass: Benzenoids
• Class: Benzene and substituted derivatives
• Subclass: Methoxybenzenes
• Intermediate Tree Nodes: Not available
• Direct Parent: Dimethoxybenzenes
• Alternative Parents: Methoxyanilines Phenoxy compounds Anisoles Alkyl aryl ethers Bromobenzenes Aryl bromides Thiazolidines Tertiary carboxylic acid amides Lactams Dialkylthioethers Azacyclic compounds Carbonyl compounds Organonitrogen compounds Organic oxides Organobromides Hydrocarbon derivatives
• Molecular Framework: Aromatic heteromonocyclic compounds
• Substituents: M-dimethoxybenzene - Dimethoxybenzene - Methoxyaniline - Phenoxy compound - Anisole - Phenol ether - Alkyl aryl ether - Bromobenzene - Halobenzene - Aryl bromide - Aryl halide - Tertiary carboxylic acid amide - Thiazolidine - Carboxamide group - Lactam - Organoheterocyclic compound - Ether - Carboxylic acid derivative - Azacycle - Dialkylthioether - Thioether - Organooxygen compound - Organonitrogen compound - Organobromide - Organohalogen compound - Organic oxygen compound - Organic nitrogen compound - Carbonyl group - Hydrocarbon derivative - Organic oxide - Aromatic heteromonocyclic compound
• Description: This compound belongs to the class of organic compounds known as dimethoxybenzenes. These are organic aromatic compounds containing a monocyclic benzene moiety carrying exactly two methoxy groups.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Associated Targets(Human)

A549 (127892 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Chemical and Physical Properties

• Molecular Weight: 394.300 g/mol
• XLogP3: 4.000
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 4
• Exact Mass: 393.003 Da
• Monoisotopic Mass: 393.003 Da
• Topological Polar Surface Area: 64.099 Ų
• Heavy Atom Count: 23
• Formal Charge: 0
• Complexity: 425.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 1
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1