ClozapineN-oxide dihydrochloride - ≥98% , CAS No.2250025-93-3

CAS: 2250025-93-3 Cat. No.: C287498 Molecular Weight: 415.74 PubChem CID: 137187247

GRADE & PURITY ≥98%

Synonyms

CNO (water-soluble) | 8-Chloro-11-(4-methyl-4-oxido-1-piperazinyl)-5H-dibenzo[b,e][1,4]diazepine dihydrochloride

Storage

Store at -20°C,Desiccated

Shipped In

Ice chest + Ice pads

Specifications

Synonyms

CNO (water-soluble) | 8-Chloro-11-(4-methyl-4-oxido-1-piperazinyl)-5H-dibenzo[b, e][1, 4]diazepine dihydrochloride

Specifications & Purity

≥98%

Biochemical and Physiological Mechanisms

Water soluble salt of Clozapine N-oxide. Activator of muscarinic DREADDs. Exhibits improved bioavailability (6 - 7-fold higher plasma concentration) compared with CNO, with less conversion to clozapine in animal studies.

Storage

Store at -20°C, Desiccated

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Purity

≥98%

Names and Identifiers

• Pubchem Sid: 504773483
• Pubchem Sid Url: https://pubchem.ncbi.nlm.nih.gov/substance/504773483
• Canonical Smiles: C[N+]1(CCN(CC1)C2=NC3=C(C=CC(=C3)Cl)NC4=CC=CC=C42)[O-].Cl.Cl
• IUPAC Name: 3-chloro-6-(4-methyl-4-oxidopiperazin-4-ium-1-yl)-11H-benzo[b][1,4]benzodiazepine;dihydrochloride
• InChIKey: MBRGKRXDVKTUPT-UHFFFAOYSA-N
• INCHI: 1S/C18H19ClN4O.2ClH/c1-23(24)10-8-22(9-11-23)18-14-4-2-3-5-15(14)20-16-7-6-13(19)12-17(16)21-18;;/h2-7,12,20H,8-11H2,1H3;2*1H
• PubChem CID: 137187247
• Molecular Weight: 415.74

Chemical and Physical Properties

• Solubility: Solvent:water, Max Conc. mg/mL: 41.57, Max Conc. mM: 100; Solvent:DMSO, Max Conc. mg/mL: 41.57, Max Conc. mM: 100