Cytidine 5′-triphosphate disodium salt - 10mM in Water , CAS No.36051-68-0

CAS: 36051-68-0 Cat. No.: C423622 Molecular Weight: 527.12 EC Number: 252-849-3 PubChem CID: 16219084

GRADE & PURITY 10mM in Water

Synonyms

36051-68-0|Cytidine-5'-triphosphate disodium salt|Cytidine 5'-triphosphate disodium salt|Cytidine-5'-triphosphoric acid disodium salt|disodium;[[[(2R,3S,4R,5R)-5-(4-amino-2-oxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-oxidophosphoryl]oxy-hydroxypho

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

Cytidine 5′-triphosphate is a nucleoside triphosphate with a pyrimidine ring. It is present in RNA

Cytidine 5′-triphosphate disodium salt has been used:

• for the conversion of adenosine monophosphate (AMP) to adenosine diphosphate (ADP) in luminometry analysis

• in the preparation of ribonucleotide 5′-triphosphate precursors stocks for large-scale RNA synthesis

• to perform in vitro transcription

Specifications

Synonyms

36051-68-0 | Cytidine-5'-triphosphate disodium salt | Cytidine 5'-triphosphate disodium salt | Cytidine-5'-triphosphoric acid disodium salt | disodium;[[[(2R, 3S, 4R, 5R)-5-(4-amino-2-oxopyrimidin-1-yl)-3, 4-dihydroxyoxolan-2-yl]methoxy-oxidophosphoryl]oxy-hydroxypho

Specifications & Purity

10mM in Water

Biochemical and Physiological Mechanisms

Pyrimidine nucleoside triphosphate involved in a variety of biochemical reactions. Used in the synthesis of RNA by RNA polymerases. Used as a substrate for CMP-neuNAc synthetase(s) which produce CMP-neuNAc used in sialylation reactions.

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Names and Identifiers

• Canonical Smiles: C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)([O-])OP(=O)(O)OP(=O)(O)[O-])O)O.[Na+].[Na+]
• IUPAC Name: disodium;[[[(2R,3S,4R,5R)-5-(4-amino-2-oxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-oxidophosphoryl]oxy-hydroxyphosphoryl] hydrogen phosphate
• InChIKey: NFQMDTRPCFJJND-WFIJOQBCSA-L
• INCHI: 1S/C9H16N3O14P3.2Na/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18;;/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H2,10,11,15)(H2,16,17,18);;/q;2*+1/p-2/t4-,6-,7-,8-;;/m1../s1
• Isomeric SMILES: C1=CN(C(=O)N=C1N)[C@H]2[C@@H]([C@@H]([C@H](O2)COP(=O)([O-])OP(=O)(O)OP(=O)(O)[O-])O)O.[Na+].[Na+]
• WGK Germany: 3
• Alternate CAS: 123334-07-6
• PubChem CID: 16219084
• Molecular Weight: 527.12

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Nucleosides, nucleotides, and analogues
    • Class Pyrimidine nucleotides
      • Subclass Pyrimidine ribonucleotides

• Kingdom: Organic compounds
• Superclass: Nucleosides, nucleotides, and analogues
• Class: Pyrimidine nucleotides
• Subclass: Pyrimidine ribonucleotides
• Intermediate Tree Nodes: Not available
• Direct Parent: Pyrimidine ribonucleoside triphosphates
• Alternative Parents: Pentose phosphates Glycosylamines Monosaccharide phosphates Aminopyrimidines and derivatives Pyrimidones Monoalkyl phosphates Hydropyrimidines Imidolactams Heteroaromatic compounds Oxolanes Secondary alcohols 1,2-diols Oxacyclic compounds Azacyclic compounds Organic zwitterions Hydrocarbon derivatives Primary amines Organic sodium salts Organic oxides
• Molecular Framework: Aromatic heteromonocyclic compounds
• Substituents: Pyrimidine ribonucleoside triphosphate - Pentose phosphate - Pentose-5-phosphate - Glycosyl compound - N-glycosyl compound - Monosaccharide phosphate - Pentose monosaccharide - Aminopyrimidine - Pyrimidone - Monoalkyl phosphate - Hydropyrimidine - Monosaccharide - Organic phosphoric acid derivative - Phosphoric acid ester - Pyrimidine - Alkyl phosphate - Imidolactam - Oxolane - Heteroaromatic compound - Secondary alcohol - 1,2-diol - Organoheterocyclic compound - Organic alkali metal salt - Oxacycle - Azacycle - Organooxygen compound - Organonitrogen compound - Amine - Alcohol - Hydrocarbon derivative - Organic salt - Organic sodium salt - Organic oxygen compound - Primary amine - Organic nitrogen compound - Organic zwitterion - Organic oxide - Aromatic heteromonocyclic compound
• Description: This compound belongs to the class of organic compounds known as pyrimidine ribonucleoside triphosphates. These are pyrimidine ribobucleotides with triphosphate group linked to the ribose moiety.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Chemical and Physical Properties

• Flash Point(°F): 235.4 °F
• Flash Point(°C): 113 °C

References

1. Ting Zeng, Jie Yin, Ziwen Liu, Zhaoxing Li, Yu Zhang, Yang Lv, Mei-Ling Lu, Min Luo, Meirong Chen, Yibei Xiao.  (2023)  Mechanistic insights into transposon cleavage and integration by TnsB of ShCAST system.  Cell Reports,      [PMID:37379212] [10.1016/j.celrep.2023.112698]

2. Yang Tian, Qiuyu Bao, Nian Wang, Ning Wan, Langlang Lv, Haiping Hao, Chaoyong He, Hui Ye.  (2020)  Time-Resolved Acetaldehyde-Based Accessibility Profiling Maps Ligand–Target Interactions.  JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY,      [PMID:33382614] [10.1021/jasms.0c00382]

3. Sun Chao, Zhao Shiyu, Qu Fei, Han Wenli, You Jinmao.  (2019)  Determination of adenosine triphosphate based on the use of fluorescent terbium(III) organic frameworks and aptamer modified gold nanoparticles.  MICROCHIMICA ACTA,  187  (1): (1-9).  [PMID:31814046] [10.1007/s00604-019-4019-z]

4. Guimei Wang, Xiaoxue Jiang, Nanyan Fu.  (2019)  Near-infrared squaraine fluorescent probe for imaging adenosine 5′-triphosphate in live cells.  DYES AND PIGMENTS,      [PMID:] [10.1016/j.dyepig.2019.107698]

5. Fei Qu, Jingwen Li, Wenli Han, Lian Xia, Jinmao You.  (2018)  Simultaneous Detection of Adenosine Triphosphate and Glucose Based on the Cu-Fenton Reaction.  SENSORS,  18  (7): (2151).  [PMID:29973531] [10.3390/s18072151]

6. Ying Ding, Qingyan Jia, Yongmei Wen, Weimin Liu, Jiechao Ge, Jiasheng Wu, Hongyan Zhang, Pengfei Wang.  (2018)  New detection method for nucleoside triphosphates based on carbon dots: The distance-dependent singlet oxygen trapping.  ANALYTICA CHIMICA ACTA,      [PMID:30119732] [10.1016/j.aca.2018.05.024]

7. Yi Lin, Yidi Yang, Jianqin Yan, Jun Chen, Jun Cao, Yuji Pu, Li Li, Bin He.  (2018)  Redox/ATP switchable theranostic nanoparticles for real-time fluorescence monitoring of doxorubicin delivery.  Journal of Materials Chemistry B,  6  (14): (2089-2103).  [PMID:32254432] [10.1039/C7TB03325G]

8. Qu Fei, Mao Beibei, Xue Fangfang, Xia Lian, You Jinmao, Song Cuihua.  (2018)  Photoinduced electron transfer from polymer-templated Ag nanoclusters to G-quadruplex-hemin complexes for the construction of versatile biosensors and logic gate applications.  ANALYTICAL AND BIOANALYTICAL CHEMISTRY,  410  (8): (2211-2219).  [PMID:29387952] [10.1007/s00216-018-0887-z]

9. Xinlv Peng, Caixia Pei, Eika W. Qian, Yuguang Du, Jian-Jun Li.  (2024)  Co-immobilization of a bi-enzymatic cascade into hierarchically porous MIL-53 for efficient 6′-sialyllactose production.  Nanoscale,      [PMID:39046038] [10.1039/D4NR01775G]

10. Zejin Liu, Mengyang Sun, Wenhua Liu, Fangyu Feng, Xinyu Li, Chaolei Jin, Yijie Zhang, Junpeng Wang.  (2024)  Deficiency of purinergic P2X4 receptor alleviates experimental autoimmune hepatitis in mice.  BIOCHEMICAL PHARMACOLOGY,      [PMID:38301964] [10.1016/j.bcp.2024.116033]

11. Yuanyuan Su, Minghui Gu, Cheng Li, Dequan Zhang, Yuqing Ren, Li Chen, Shaobo Li, Xiaochun Zheng.  (2024)  Development of a rhodamine-based fluorescent probe for ATP detection for potential applications in meat freshness assessment.  FOOD CHEMISTRY,      [PMID:38615529] [10.1016/j.foodchem.2024.139209]

12. Yanhao Zhang, Zifang Peng, Peiru Luo, Lin Zhu, Qingyun He, Congcong Pei, Dan Yin, Wenfen Zhang, Shusheng Zhang, Zongwei Cai.  (2024)  Diamide insecticides in PM2.5: The unreported rural and urban air pollutants.  JOURNAL OF HAZARDOUS MATERIALS,      [PMID:39754883] [10.1016/j.jhazmat.2024.137055]

13. Yuqing Zhang, Chunli Yang, Jiayang He, Zhihan Zhang, Yaqin Chai, Ruo Yuan, Wenju Xu.  (2025)  Dynamic switching circuit modulated by intramolecular conformation transition of DNA translator for versatile fluorescence biosensors.  BIOSENSORS & BIOELECTRONICS,      [PMID:40139051] [10.1016/j.bios.2025.117404]

14. Xiaojiao Dai, Ziling Huang, Chuanyi Liu, Zhigang Li, Qingmin Chen, Yi Xu, Xiaomei Chen, Quansheng Chen, Jie Wei.  (2024)  Engineering of a DNAzyme-based aptasensor for highly efficient ATP detection and oyster freshness evaluation.  JOURNAL OF FOOD COMPOSITION AND ANALYSIS,      [PMID:] [10.1016/j.jfca.2024.107176]

15. Zi-Xuan Hu, Shu-Rui Li, Qing-Jun Xia, Ting Wang, Josef Voglmeir, Göran Widmalm, Li Liu.  (2024)  Enzymatic synthesis of N-formylated sialosides via a five-enzyme cascade.  ORGANIC & BIOMOLECULAR CHEMISTRY,  22  (36): (7485-7491).  [PMID:39189395] [10.1039/D4OB00874J]

16. Min Long, Jiayang He, Xinyue Jia, Yuqing Zhang, Zhihan Zhang, Yaqin Chai, Ruo Yuan, Wenju Xu.  (2024)  Ligand-induced minimal strand proximity hybridization to illuminate biemissive Ag nanocluster for ratiometric fluorescence biosensing.  SENSORS AND ACTUATORS B-CHEMICAL,      [PMID:] [10.1016/j.snb.2024.137085]

17. Xiaomeng Zhou, Saijin Huang, Wenfeng Liu, Li Shang.  (2024)  Metal Ion-Regulated Fluorescent Sensor Array Based on Gold Nanoclusters for Physiological Phosphate Sensing.  ANALYTICAL CHEMISTRY,      [PMID:38421217] [10.1021/acs.analchem.3c05582]

18. Xiaomeng Zhou, Saijin Huang, Wenfeng Guo, Wenfeng Liu, Mengyao Wen, Li Shang.  (2024)  Multicolor Gold Clusterzyme-Enabled Construction of Ratiometric Fluorescent Sensor Array for Visual Biosensing.  ANALYTICAL CHEMISTRY,      [PMID:39546635] [10.1021/acs.analchem.4c04701]

19. Hong Huang, Huiru Li, Yong Zhang, Xuhan Xia, Ningwen Zhang, Haixin Fan, Longhua Guo, Yongyong Cao, Hu Pan, Ruijie Deng, Yangang Wang, Rodrigo Ledesma-Amaro, Jianguo Xu.  (2025)  Simultaneous Monitoring of Tyrosinase and ATP in Thick Brain Tissues Using a Single Two-Photon Fluorescent Probe.  Advanced Science,      [PMID:40129186] [10.1002/advs.202413220]

20. Jiarong Lv, Qinchuan Wei, Xuewen Gong, Enming Du, Shijin Zhang.  (2024)  Simultaneously monitoring ATP and neutrophil elastase to assess inflammation progression.  SENSORS AND ACTUATORS B-CHEMICAL,      [PMID:] [10.1016/j.snb.2024.136676]

21. Ruo-Fei Ma, Qi Zhang, Yue Wang, Zhang-Run Xu.  (2024)  Visualizing mitochondrial ATP fluctuations in single cells during photodynamic therapy by In-Situ SERS three-dimensional imaging.  SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY,      [PMID:39128309] [10.1016/j.saa.2024.124910]

22. Yating Li, Jason Tan, Yanqin Tu, Jingnan Wu, Zaifang Zhang, Yifeng Wei, Xinan Jiao, Yan Zhou.  (2025)  Distinct Phage-Encoded Enzymes for Substitution of Deoxythymidine by Deoxyuridine in Phage Genomes.  Advanced Science,      [PMID:41001765] [10.1002/advs.202512937]

23. Yunjie Ren, Yueyuan Li, Min Qing, Yonghua Yuan, Jing Zhou, Lijuan Bai.  (2025)  MOF-Wrapped Cu Nanocluster-Based Fluorescent Sensor Array for Phosphates High-Throughput Analysis and Their Enzymatic Hydrolysis Monitoring.  ACS Applied Nano Materials,      [PMID:] [10.1021/acsanm.5c02996]

24. Jie Lv, Shuangling Wang, Cong Zhang, Yulong Lin, Yan Fu, Meng Li.  (2020)  ATP induced alteration in the peroxidase-like properties of hollow Prussian blue nanocubes: a platform for alkaline phosphatase detection.  ANALYST,  145  (14): (5032-5040).  [PMID:32658942] [10.1039/D0AN00405G]

25. Lingchen Wang, Yue Huang, Linlin Sun, Xiaojuan Gong, Chuan Dong, Shaomin Shuang.  (2025)  A novel AIEgen-Based probe Integrated with split aptamer Conjugates for adenosine triphosphate detection in beer.  SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY,      [PMID:40349396] [10.1016/j.saa.2025.126332]

26. Haoran Zheng, Jiayu Guo, Han Wang, Yurou Wang, Wenxiang Zhou, Ke Liu, Qiang Ma, Yanfei Qi.  (2025)  A zeolitic imidazolate framework-90 enhanced ultrasensitive ATP sensing platform with HCR and CRISPR-Cas12a dual signal amplification for live bacteria detection.  JOURNAL OF HAZARDOUS MATERIALS,      [PMID:40378737] [10.1016/j.jhazmat.2025.138612]

27. Yuzhu Li, Juanjuan Zhu, Cheng Wang, Mengke Su, Honglin Liu.  (2025)  A Woundplast of Hydrogel Microneedles with In Vivo ATP-Responsive Therapeutic Logic for Bacteria-Infected Wound Healing.  ANALYTICAL CHEMISTRY,      [PMID:40525619] [10.1021/acs.analchem.5c02891]

28. Tingsong Ye, Rongwei Cui, Xin Zhou, Yingying Huang, Xin Li, Sami Ramadan, Bing Li, Lizhou Xu, Danyang Li.  (2025)  Bidirectionally regulated catalytic performance of Hemin/oCNT based aptasensor via salt-induced charge screening for smartphone-assisted colorimetric detection of ATP.  CHEMICAL ENGINEERING JOURNAL,      [PMID:] [10.1016/j.cej.2025.172467]

29. Longcheng Gong, Chengli Xie, Tong Xu, Min Wang, Lianzhe Hu, Zhining Xia.  (2026)  Ligand-functionalized UiO-66 with tailored phosphatase-like catalytic activity for sensitive discrimination of physiological phosphates.  SENSORS AND ACTUATORS B-CHEMICAL,      [PMID:] [10.1016/j.snb.2026.139791]