Dehydrocorydalin - ≥98% , CAS No.30045-16-0

CAS: 30045-16-0 Cat. No.: D418600 Molecular Weight: 366.43

GRADE & PURITY ≥98%

Synonyms

s9431 | CHEBI:81342 | BDBM50594956 | C17790 | CCG-268242 | AC-34813 | DTXSID30904183 | Dehydrocorydalin | HY-N0674 | 7,8,13,13a-Tetradehydro-2,3,9,10-tetramethoxy-13-methylberbinium | Dibenzo[a,g]quinolizinium,5,6-dihydro-2,3,9,10-tetramethoxy-13-methyl-

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Overview

Dehydrocorydaline (13-Methylpalmatine) is an alkaloid that regulates protein expression of Bax, Bcl-2; activates caspase-7, caspase-8, and inactivates PARP. Dehydrocorydaline elevates p38 MAPK activation. Anti-inflammatory and anti-cancer activities. Dehydrocorydaline shows strong anti-malarial effects (IC50=38 nM), and low cytotoxicity (cell viability > 90%) using P. falciparum 3D7 strain.

Specifications

Synonyms

s9431 | CHEBI:81342 | BDBM50594956 | C17790 | CCG-268242 | AC-34813 | DTXSID30904183 | Dehydrocorydalin | HY-N0674 | 7, 8, 13, 13a-Tetradehydro-2, 3, 9, 10-tetramethoxy-13-methylberbinium | Dibenzo[a, g]quinolizinium, 5, 6-dihydro-2, 3, 9, 10-tetramethoxy-13-methyl-

Specifications & Purity

≥98%

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Purity

≥98%

Names and Identifiers

• Pubchem Sid: 504753537
• Pubchem Sid Url: https://pubchem.ncbi.nlm.nih.gov/substance/504753537
• Canonical Smiles: CC1=C2C=CC(=C(C2=C[N+]3=C1C4=CC(=C(C=C4CC3)OC)OC)OC)OC
• IUPAC Name: 2,3,9,10-tetramethoxy-13-methyl-5,6-dihydroisoquinolino[2,1-b]isoquinolin-7-ium
• InChIKey: RFKQJTRWODZPHF-UHFFFAOYSA-N
• INCHI: 1S/C22H24NO4/c1-13-15-6-7-18(24-2)22(27-5)17(15)12-23-9-8-14-10-19(25-3)20(26-4)11-16(14)21(13)23/h6-7,10-12H,8-9H2,1-5H3/q+1
• Isomeric SMILES: CC1=C2C=CC(=C(C2=C[N+]3=C1C4=CC(=C(C=C4CC3)OC)OC)OC)OC
• Molecular Weight: 366.43
• Reaxy-Rn: 1556798
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=1556798&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Alkaloids and derivatives
    • Class Protoberberine alkaloids and derivatives

• Kingdom: Organic compounds
• Superclass: Alkaloids and derivatives
• Class: Protoberberine alkaloids and derivatives
• Subclass: Not available
• Intermediate Tree Nodes: Not available
• Direct Parent: Protoberberine alkaloids and derivatives
• Alternative Parents: Isoquinolines and derivatives Anisoles Methylpyridines Alkyl aryl ethers Pyridinium derivatives Heteroaromatic compounds Azacyclic compounds Organopnictogen compounds Organonitrogen compounds Hydrocarbon derivatives Organic cations
• Molecular Framework: Aromatic heteropolycyclic compounds
• Substituents: Protoberberine skeleton - Isoquinoline - Anisole - Alkyl aryl ether - Methylpyridine - Benzenoid - Pyridinium - Pyridine - Heteroaromatic compound - Ether - Azacycle - Organoheterocyclic compound - Organic nitrogen compound - Organic oxygen compound - Organooxygen compound - Organonitrogen compound - Hydrocarbon derivative - Organopnictogen compound - Organic cation - Aromatic heteropolycyclic compound
• Description: This compound belongs to the class of organic compounds known as protoberberine alkaloids and derivatives. These are alkaloids with a structure based on a protoberberine moiety, which consists of a 5,6-dihydrodibenzene moiety fused to a quinolizinium and forming 5,6-Dihydrodibenzo(a,g)quinolizinium skeleton.
• External Descriptors: alkaloid

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Associated Targets(non-human)

Hdac6 Histone deacetylase 6 (222 Activities)

Discover Target: Hdac6

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Chemical and Physical Properties

• Solubility: DMSO: 66 mg/mL(180.1 mM) Chloroform, Dichloromethane, Ethyl Acetate, Acetone, etc.: Soluble
• Molecular Weight: 366.400 g/mol
• XLogP3: 4.100
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 4
• Exact Mass: 366.171 Da
• Monoisotopic Mass: 366.171 Da
• Topological Polar Surface Area: 40.800 Ų
• Heavy Atom Count: 27
• Formal Charge: 1
• Complexity: 503.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1

References

1. Wentao Liu, Yuan Wang, Chen Liu, Bowei Shi, Xiaowei Xiong, Sheng Chen, Qianqian Huang, Li Wang, Guohua Zeng, Qiren Huang.  (2025)  Pro-Atherosclerotic Effects of Osteopontin Is Contributed to Promoting Foam Cell Formation Derived From VSMCs by Inhibiting Cholesterol Efflux.  FASEB JOURNAL,  39  (9): (e70608).  [PMID:40332823] [10.1096/fj.202403104RR]