Dexelvucitabine - ≥99% , Human immunodeficiency virus type 1 reverse transcriptase inhibitor, CAS No.134379-77-4, Human immunodeficiency virus type 1 reverse transcriptase inhibitor

CAS: 134379-77-4 Cat. No.: D650133 Molecular Weight: 227.19

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Dexelvucitabine - ≥99% CAS No(134379-77-4) by Aladdin Scientific

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AVAILABLE TO ORDER

GRADE & PURITY ≥99%

Synonyms

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Overview Specifications Product Properties Names and Identifiers Documentation Advanced Data Taxonomic Classification 3D Structure Associated Targets(Human) Associated Targets(non-human) Mechanisms of Action Certificates（CoA,COO,BSE/TSE and Analysis Chart) Chemical and Physical Properties Solution Calculators Reviews

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Why this grade

≥99% for sensitive chromatographic and analytical workflows requiring minimal baseline interference.

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Storage & shipping

Store at -20°C Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.

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Quality documents

SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.

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Literature proof

Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.

Overview

Dexelvucitabine (Reverset; d-d4FC), a Cytidine analog, is an orally active nucleoside reverse transcriptase inhibitor. Dexelvucitabine is a powerful agent against HIV-1-resistant viruses containing a thymidine analog and/or M184V mutation in the viral polymerase. Dexelvucitabine is a 2′-Deoxycytidine antiretroviral agent

In Vivo

Dexelvucitabine (Reverset; d-d4FC; 33.3 mg/kg by i.v. or p.o.) has distribution and elimination half-lives (t 1/2α and t 1/2β , respectively) of 0.7 and 3.6 h in monkeys, respectively. The C max ranges from 21.1 to 47.5 μM. Dexelvucitabine has a favorable pharmacokinetic profile with a long half-life (4.71 and 10.75 h after administration by the intravenous [i.v.] and oral [p.o.] routes, respectively) in woodchucks. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Form:Solid

IC50& Target:HIV-1

Specifications

Synonyms

2', 3'-Dideoxy-2', 3'-didehydro-beta-L-5-fluorocytidine | INCB-8721 | KU8SPJ271W | CYTIDINE, 2', 3'-DIDEHYDRO-2', 3'-DIDEOXY-5-FLUORO | Cytidine, 2', 3'-didehydro-2', 3'-dideoxy-5-fluoro- | 4-amino-5-fluoro-1-[(2R, 5S)-5-(hydroxymethyl)-2, 5-dihydrofuran-2-yl]pyr

Specifications & Purity

≥99%

Biochemical and Physiological Mechanisms

Dexelvucitabine (Reverset; d-d4FC), a Cytidine ( HY-B0158 ) analog, is an orally active nucleoside reverse transcriptase inhibitor. Dexelvucitabine is a powerful agent against HIV-1-resistant viruses containing a thymidine analog and/or M184V mutation in

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Action Type

INHIBITOR

Mechanism of action

Human immunodeficiency virus type 1 reverse transcriptase inhibitor

Purity

≥99%

Product Properties

ALogP	-1.3

Names and Identifiers

Canonical Smiles	C1=CC(OC1CO)N2C=C(C(=NC2=O)N)F
IUPAC Name	4-amino-5-fluoro-1-[(2R,5S)-5-(hydroxymethyl)-2,5-dihydrofuran-2-yl]pyrimidin-2-one
InChIKey	HSBKFSPNDWWPSL-CAHLUQPWSA-N
INCHI	1S/C9H10FN3O3/c10-6-3-13(9(15)12-8(6)11)7-2-1-5(4-14)16-7/h1-3,5,7,14H,4H2,(H2,11,12,15)/t5-,7+/m0/s1
Isomeric SMILES	C1=C[C@@H](O[C@@H]1CO)N2C=C(C(=NC2=O)N)F
Alternate CAS	134379-77-4
MeSH Entry Terms	2',3'-dideoxy-2',3'-didehydro-5-fluorocytidine;2',3'-dideoxy-2',3'-didehydro-beta-D-5-fluorocytidine;2',3'-dideoxy-2',3'-didehydro-beta-L-5-fluorocytidine;2(1H)-Pyrimidinone, 4-amino-1-((2S,5R)-2,5-dihydro-5-(hydroxymethyl)-2-furanyl)-5-fluoro-;4-amino-5-
Molecular Weight	227.19
Reaxy-Rn	24713405
Reaxys-RN_link_address	https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=24713405&ln=

Documentation

📋 Safety Data Sheet (SDS)

Comprehensive hazard, handling, storage, and regulatory compliance document.

Download SDS →

✅ Certificate of Analysis (COA)

Lot-specific quality data. Enter your lot number to retrieve the exact COA.

Look up COA →

📊 Datasheet

Quick-reference summary of product specifications and applications.

View datasheet →

🔬 Specification Sheet

Full quality attributes and acceptance criteria for this grade.

View spec sheet →

Advanced Data

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Nucleosides, nucleotides, and analogues
  - Class Nucleoside and nucleotide analogues

Kingdom	Organic compounds
Superclass	Nucleosides, nucleotides, and analogues
Class	Nucleoside and nucleotide analogues
Subclass	Not available
Intermediate Tree Nodes	Not available
Direct Parent	Nucleoside and nucleotide analogues
Alternative Parents	Pyrimidones Aminopyrimidines and derivatives Halopyrimidines Aryl fluorides Hydropyrimidines Imidolactams Heteroaromatic compounds Dihydrofurans Azacyclic compounds Oxacyclic compounds Organic oxides Primary amines Hydrocarbon derivatives Primary alcohols Organofluorides Organopnictogen compounds
Molecular Framework	Aromatic heteromonocyclic compounds
Substituents	Aminopyrimidine - Halopyrimidine - Pyrimidone - Aryl fluoride - Aryl halide - Hydropyrimidine - Pyrimidine - Imidolactam - Dihydrofuran - Heteroaromatic compound - Oxacycle - Azacycle - Organoheterocyclic compound - Primary alcohol - Organooxygen compound - Organonitrogen compound - Organofluoride - Organohalogen compound - Alcohol - Hydrocarbon derivative - Organic oxide - Organopnictogen compound - Organic oxygen compound - Primary amine - Amine - Organic nitrogen compound - Aromatic heteromonocyclic compound
Description	This compound belongs to the class of organic compounds known as nucleoside and nucleotide analogues. These are analogues of nucleosides and nucleotides. These include phosphonated nucleosides, C-glycosylated nucleoside bases, analogues where the sugar unit is a pyranose, and carbocyclic nucleosides, among others.
External Descriptors	Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

3D Structure

Associated Targets(Human)

CCRF-CEM (65223 Activities)

Solubility	DMSO : 50 mg/mL (220.08 mM; Need ultrasonic)
Molecular Weight	227.190 g/mol
XLogP3	-1.300
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	2
Exact Mass	227.071 Da
Monoisotopic Mass	227.071 Da
Topological Polar Surface Area	88.200 Å²
Heavy Atom Count	16
Formal Charge	0
Complexity	405.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	2
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	1