Diclofenac Diethylamine - 10mM in DMSO , CAS No.78213-16-8

CAS: 78213-16-8 Cat. No.: D408194 Molecular Weight: 369.29 EC Number: 616-599-2

GRADE & PURITY 10mM in DMSO

Synonyms

Benzeneacetic acid, 2-[(2,6-dichlorophenyl)amino]-, compd. with N-ethylethanamine (1:1)

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

Information

Diclofenac Diethylamine Diclofenac diethylamine is a nonsteroidal anti-inflammatory drug taken to reduce inflammation and as an analgesic reducing pain in certain conditions. Diclofenac exerts its action via inhibition of prostaglandin synthesis by inhi
In vitro

The primary mechanism of diclofenac diethylamine responsible for its anti-inflammatory, antipyretic, and analgesic action is thought to be inhibition of prostaglandin synthesis by inhibition of cyclooxygenase (COX). It also appears to exhibit bacteriostatic activity by inhibiting bacterial DNA synthesis. Inhibition of COX also decreases prostaglandins in the epithelium of the stomach, making it more sensitive to corrosion by gastric acid. This is also the main side effect of diclofenac. Diclofenac diethylamine has a low to moderate preference to block the COX2-isoenzyme (approximately 10-fold) and is said to have, therefore, a somewhat lower incidence of gastrointestinal complaints than noted with indomethacin and aspirin.

In vivo

Cell Data

cell lines：murine melanoma cell subline(B16-R)

Concentrations：

Incubation Time：

Powder Purity:≥99%

Specifications

Synonyms

Benzeneacetic acid, 2-[(2, 6-dichlorophenyl)amino]-, compd. with N-ethylethanamine (1:1)

Specifications & Purity

10mM in DMSO

Biochemical and Physiological Mechanisms

Diclofenac diethylamine is a nonsteroidal anti-inflammatory drug taken to reduce inflammation and as an analgesic reducing pain in certain conditions. Diclofenac exerts its action via inhibition of prostaglandin synthesis by inhibiting cyclooxygenase-1 (C

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Names and Identifiers

• Isomeric SMILES: CCNCC.C1=CC=C(C(=C1)CC(=O)O)NC2=C(C=CC=C2Cl)Cl
• Molecular Weight: 369.29
• Reaxy-Rn: 6461225
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=6461225&ln=

Chemical and Physical Properties

• Melt Point(°C): 150-156°C