DMXAA (Vadimezan) - Moligand™, ≥98% , CAS No.117570-53-3

CAS: 117570-53-3 Cat. No.: D129922 Molecular Weight: 282.29 EC Number: 700-141-4
AVAILABLE TO ORDER
GRADE & PURITY Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%
Synonyms
ASA404 | 5,6-MeXAA | NSC-640488 | 9H-Xanthene-4-acetic acid, 5,6-dimethyl-9-oxo- | BCPP000255 | J-003637 | 5,6-Mexaa | AC-24559 | NSC-640488 | AS-16852 | DTXSID2040949 | EN300-396606 | NCGC00165783-01 | SW219898-1 | VADIMEZAN [WHO-DD] | (5,6-dimethyl-9-ox
Storage
Store at 2-8°C
Shipped In
Wet ice
 ·  off list, applied to all prices below.
Size
Status
Price
Qty
5mg
D129922-5mg
7
$9.90
25mg
D129922-25mg
3
$13.90
100mg
D129922-100mg
4
$38.90
250mg
D129922-250mg
2
$67.90
1g
D129922-1g
1
$213.90
5g
D129922-5g
8-12 wks(?) Production requires sourcing of materials. We appreciate your patience and understanding.
$916.90
Enter a quantity for the sizes you want to add.
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Why this grade

Moligand™, ≥98% Moligand™ for sensitive chromatographic and analytical workflows requiring minimal baseline interference.

🌡

Storage & shipping

Store at 2-8°C Ships Wet ice Check lot-specific COA for exact specifications.

📋

Quality documents

SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.

📚

Literature proof

Cited in 9 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.

Overview

5,6-dimethylxanthenone-4-acetic acid (DMXAA) is a flavone acetic acid derivative. It acts as a vascular disrupting agent (VDA), which damages tumor vasculature and stimulates an anti-tumor immune response. It stimulates hemorrhagic necrosis.
An apoptosis inducer for proteomics research.

Specifications

Synonyms
ASA404 | 5, 6-MeXAA | NSC-640488 | 9H-Xanthene-4-acetic acid, 5, 6-dimethyl-9-oxo- | BCPP000255 | J-003637 | 5, 6-Mexaa | AC-24559 | NSC-640488 | AS-16852 | DTXSID2040949 | EN300-396606 | NCGC00165783-01 | SW219898-1 | VADIMEZAN [WHO-DD] | (5, 6-dimethyl-9-ox
Specifications & Purity
Moligand™, ≥98%
Biochemical and Physiological Mechanisms
DMXAA is an apoptosis inducer, and an anti-vascular. DMXAA is an inhibitor of NQO1, Flk-1 and Flt-1.Vascular disrupting agent. VEGFR inhibitor. Potent type I interferon inducer. Increases vascular permeability and vascular endothelial apoptosis. Inhibits
Storage
Store at 2-8°C
Shipped In
Wet ice
This product requires cold chain shipping. Ground and other economy services are not available.
Grade
Moligand™
Action Type
INHIBITOR
Note
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Purity
≥98%
Names and Identifiers
Pubchem Sid488187781
Pubchem Sid Urlhttps://pubchem.ncbi.nlm.nih.gov/substance/488187781
Canonical SmilesCC1=C(C2=C(C=C1)C(=O)C3=CC=CC(=C3O2)CC(=O)O)C
IUPAC Name2-(5,6-dimethyl-9-oxoxanthen-4-yl)acetic acid
InChIKeyXGOYIMQSIKSOBS-UHFFFAOYSA-N
INCHI1S/C17H14O4/c1-9-6-7-13-15(20)12-5-3-4-11(8-14(18)19)17(12)21-16(13)10(9)2/h3-7H,8H2,1-2H3,(H,18,19)
Isomeric SMILES CC1=C(C2=C(C=C1)C(=O)C3=CC=CC(=C3O2)CC(=O)O)C
WGK Germany 3
RTECS ZD5536200
Molecular Weight 282.29
Reaxy-Rn 4262852
Reaxys-RN_link_address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=4262852&ln=

Documentation

📋 Safety Data Sheet (SDS)

Comprehensive hazard, handling, storage, and regulatory compliance document.

Download SDS →

✅ Certificate of Analysis (COA)

Lot-specific quality data. Enter your lot number to retrieve the exact COA.

Look up COA →

📊 Datasheet

Quick-reference summary of product specifications and applications.

View datasheet →

🔬 Specification Sheet

Full quality attributes and acceptance criteria for this grade.

View spec sheet →

Advanced Data

Taxonomic Classification

Taxonomy Tree

KingdomOrganic compounds
SuperclassOrganoheterocyclic compounds
ClassBenzopyrans
Subclass1-benzopyrans
Intermediate Tree Nodes Dibenzopyrans - Xanthenes
Direct ParentXanthones
Alternative Parents Chromones  Pyranones and derivatives  Benzenoids  Heteroaromatic compounds  Oxacyclic compounds  Monocarboxylic acids and derivatives  Carboxylic acids  Organic oxides  Hydrocarbon derivatives  Carbonyl compounds  
Molecular FrameworkAromatic heteropolycyclic compounds
Substituents Xanthone - Chromone - Pyranone - Pyran - Benzenoid - Heteroaromatic compound - Monocarboxylic acid or derivatives - Carboxylic acid - Carboxylic acid derivative - Oxacycle - Carbonyl group - Hydrocarbon derivative - Organic oxide - Organooxygen compound - Organic oxygen compound - Aromatic heteropolycyclic compound
DescriptionThis compound belongs to the class of organic compounds known as xanthones. These are polycyclic aromatic compounds containing a xanthene moiety conjugated to a ketone group at carbon 9. Xanthene is a tricyclic compound made up of two benzene rings linearly fused to each other through a pyran ring.
External Descriptors monocarboxylic acid - xanthones
3D Structure
Interactive Chemical Structure Model





Associated Targets(Human)
GLA Tclin Alpha-galactosidase A (5444 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Homo sapiens (32628 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
BeWo (124 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Caco-2 (12174 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
COLO 320 (353 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HL-60 (67320 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HT-29 (80576 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
K562 (73714 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
MCF7 (126967 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SiHa (2051 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
A549 (127892 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
BJ (6930 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HepG2 (196354 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HUVEC (11049 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Ishikawa (877 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HeLa (62764 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
MDA-MB-231 (73002 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PBMC (10003 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
TP53 Tchem Tumour suppressor p53/oncoprotein Mdm2 (2075 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
L02 (4864 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Associated Targets(non-human)
Hdac6 Histone deacetylase 6 (222 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mus musculus (284745 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CCRF S-180 (1031 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
MC-38 (857 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
NIH3T3 (5395 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Splenocyte (1641 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CT26 (928 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
rep Replicase polyprotein 1ab (378 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SARS-CoV-2 (38078 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mechanisms of Action
Certificates(CoA,COO,BSE/TSE and Analysis Chart)
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

37 results found

Lot NumberCertificate TypeDateItem
E2619340Certificate of AnalysisApr 27, 2026 D129922
E2619339Certificate of AnalysisApr 27, 2026 D129922
E2619341Certificate of AnalysisApr 27, 2026 D129922
E2619353Certificate of AnalysisApr 27, 2026 D129922
E2619352Certificate of AnalysisApr 27, 2026 D129922
E2619350Certificate of AnalysisApr 27, 2026 D129922
G2326412Certificate of AnalysisMay 09, 2025 D129922
G2326397Certificate of AnalysisMay 09, 2025 D129922
G2326399Certificate of AnalysisMay 09, 2025 D129922
E2325450Certificate of AnalysisMar 04, 2025 D129922
E2325452Certificate of AnalysisMar 04, 2025 D129922
E2325453Certificate of AnalysisMar 04, 2025 D129922
E2325456Certificate of AnalysisMar 04, 2025 D129922
E2325457Certificate of AnalysisMar 04, 2025 D129922
E2325458Certificate of AnalysisMar 04, 2025 D129922
E2325459Certificate of AnalysisMar 04, 2025 D129922
E2325461Certificate of AnalysisMar 04, 2025 D129922
A2517348Certificate of AnalysisDec 27, 2024 D129922
D2524051Certificate of AnalysisDec 27, 2024 D129922
D2508108Certificate of AnalysisDec 27, 2024 D129922
A2517347Certificate of AnalysisDec 27, 2024 D129922
A2517349Certificate of AnalysisDec 27, 2024 D129922
A2517350Certificate of AnalysisDec 27, 2024 D129922
F2414246Certificate of AnalysisMay 27, 2024 D129922
F2414251Certificate of AnalysisMay 27, 2024 D129922
F2414255Certificate of AnalysisMay 27, 2024 D129922
F2414256Certificate of AnalysisMay 27, 2024 D129922
G2201285Certificate of AnalysisApr 07, 2024 D129922
I2124095Certificate of AnalysisJul 17, 2023 D129922
G2326395Certificate of AnalysisJul 06, 2023 D129922
K1913123Certificate of AnalysisJun 08, 2023 D129922
E2325454Certificate of AnalysisMay 08, 2023 D129922
D2115334Certificate of AnalysisJan 17, 2023 D129922
G2201366Certificate of AnalysisJun 05, 2022 D129922
G2201286Certificate of AnalysisJun 05, 2022 D129922
G2201277Certificate of AnalysisJun 05, 2022 D129922
G2201210Certificate of AnalysisJun 05, 2022 D129922

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Chemical and Physical Properties
SolubilitySoluble in DMSO (>10 mg/ml), DMF (~14 mg/ml), 1:1 solution of DMF: PBS (pH=7.2) (~0.5 mg/ml), water (<1 mg/ml at 25 °C), and ethanol (<1 mg/ml at 25 °C).
Sensitivityheat sensitive
Melt Point(°C)264 °C
Molecular Weight282.290 g/mol
XLogP33.200
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count4
Rotatable Bond Count2
Exact Mass282.089 Da
Monoisotopic Mass282.089 Da
Topological Polar Surface Area63.600 Ų
Heavy Atom Count21
Formal Charge0
Complexity433.000
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
The total count of all stereochemical bonds0
Covalently-Bonded Unit Count1
Citations of This Product
References
1. Qi Long, Yuliang Yang, Fangling Liao, Haoting Chen, Dongyue He, Shengliang Li, Li Pengcheng, Weisheng Guo, Yafang Xiao.  (2023)  NIR-II Fluorescence and PA Imaging Guided Activation of STING Pathway in Photothermal Therapy for Boosting Cancer Immunotherapy by Theranostic Thermosensitive Liposomes.  Journal of Materials Chemistry B,      [PMID:37608753] [10.1039/D3TB00711A]
2. Yixuan Liu, Qi Sun, Chengfei Zhang, Min Ding, Cheng Wang, Qian Zheng, Zhijie Ma, Haojun Xu, Guoren Zhou, Xiaoming Wang, Zhangjun Cheng, Hongping Xia.  (2023)  STING-IRG1 inhibits liver metastasis of colorectal cancer by regulating the polarization of tumor-associated macrophages.  iScience,      [PMID:37554436] [10.1016/j.isci.2023.107376]
3. Yuan-Fu Ding, Ziyi Wang, Cheryl H.T. Kwong, Yonghua Zhao, Greta S.P. Mok, Hua-Zhong Yu, Ruibing Wang.  (2023)  Platelet-mimicking supramolecular nanomedicine with precisely integrated prodrugs for cascade amplification of synergistic chemotherapy.  JOURNAL OF CONTROLLED RELEASE,      [PMID:37331605] [10.1016/j.jconrel.2023.06.015]
4. Weixin Li, Zhuqi Huang, Yue Luo, Yaqian Cui, Mingjiang Xu, Wu Luo, Gaojun Wu, Guang Liang.  (2023)  Tetrandrine alleviates atherosclerosis via inhibition of STING-TBK1 pathway and inflammation in macrophages.  INTERNATIONAL IMMUNOPHARMACOLOGY,      [PMID:37099944] [10.1016/j.intimp.2023.110139]
5. Jia Liu, Zuoyu Chen, Lixue Deng, Chundong Yao, Zhixin Zhou, Cheng Zhou, Yawen Bin, Miaodeng Liu, Liping Wang, Lin Wang, Zheng Wang.  (2025)  Metal-phenolic networks specifically eliminate hypoxic tumors by instigating oxidative and proteotoxic stresses.  Bioactive Materials,      [PMID:40026824] [10.1016/j.bioactmat.2025.01.022]
6. Lirui Jia, Yang Qin, Xin Li, Hongzhuo Liu, Zhonggui He, Yongjun Wang.  (2025)  STING-activating layered double hydroxide nano-adjuvants for enhanced cancer immunotherapy.  BIOMATERIALS,      [PMID:40164041] [10.1016/j.biomaterials.2025.123294]
7. Xue Wang, Lu Liu, Yingying Chen, Lirui Jia, Yongjun Wang, Wei Jing, Guangqi Yan.  (2025)  MgZnFe-layered double hydroxides as a dual-function platform for enhancing subunit vaccine efficacy in tumor immunotherapy.  International Journal of Pharmaceutics-X,      [PMID:40978011] [10.1016/j.ijpx.2025.100384]
8. Yu-Zhang Wang, Wei-Hai Chen, Zi-Yi Han, Shi-Man Zhang, Ping Ji, Cheng Zhang, Jun-Long Liang, Xian-Zheng Zhang.  (2025)  Targeted tumor therapy with L-cyst(e)ine-addicted bacteria-nanodrug biohybrids.  Cell Metabolism,      [PMID:40215982] [10.1016/j.cmet.2025.03.012]
9. Zhanxue Xu, Xinrui Yang, Xingyu Lu, Dandan Su, Yidan Wang, Huixing Wu, Zhenhua Zhang, Changrui Long, Liqian Su, Yanyu Wang, Hongbo Chen, Shijian Xiang, Benjie Zhou.  (2025)  PD-L1 Antibody-Modified Plant-Derived Nanovesicles Carrying a STING Agonist for the Combinational Immunotherapy of Melanoma.  BIOMATERIALS,      [PMID:40367814] [10.1016/j.biomaterials.2025.123396]
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