≥97% for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Store at 2-8°C,Argon charged Ships Wet ice Check lot-specific COA for exact specifications.
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Cited in 1 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Ethyl malonyl chloride is a versatile acylating agent for propargyl alcohols, hydrazines and amines.
Ethyl malonyl chloride was used in the synthesis of:
. liquid-crystalline methanofullerodendrimers;
. 3,5-disubstituted 1,2,4-oxadiazole derivatives, which are potential peptidomimetic building blocks;
. 3-pyrrolin-2-ones via amidation with propargylamines and subsequent base catalyzed 5-exo-dig cyclization
| Canonical Smiles | CCOC(=O)CC(=O)Cl |
|---|---|
| IUPAC Name | ethyl 3-chloro-3-oxopropanoate |
| InChIKey | KWFADUNOPOSMIJ-UHFFFAOYSA-N |
| INCHI | 1S/C5H7ClO3/c1-2-9-5(8)3-4(6)7/h2-3H2,1H3 |
| Isomeric SMILES | CCOC(=O)CC(=O)Cl |
| WGK Germany | 3 |
| UN Number | 3265 |
| Molecular Weight | 150.56 |
| Beilstein | 636215 |
| Reaxy-Rn | 636215 |
| Reaxys-RN_link_address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=636215&ln= |
Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS →Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA →Full quality attributes and acceptance criteria for this grade.
View spec sheet →Taxonomy Tree
| Kingdom | Organic compounds |
|---|---|
| Superclass | Organic oxygen compounds |
| Class | Organooxygen compounds |
| Subclass | Carbonyl compounds |
| Intermediate Tree Nodes | Not available |
| Direct Parent | 1,3-dicarbonyl compounds |
| Alternative Parents | Carboxylic acid esters Monocarboxylic acids and derivatives Acyl chlorides Organochlorides Organic oxides Hydrocarbon derivatives |
| Molecular Framework | Aliphatic acyclic compounds |
| Substituents | 1,3-dicarbonyl compound - Carboxylic acid ester - Monocarboxylic acid or derivatives - Carboxylic acid derivative - Acyl halide - Acyl chloride - Organic oxide - Hydrocarbon derivative - Organochloride - Organohalogen compound - Aliphatic acyclic compound |
| Description | This compound belongs to the class of organic compounds known as 1,3-dicarbonyl compounds. These are carbonyl compounds with the generic formula O=C(R)C(H)C(R')=O, where R and R' can be any group. |
| External Descriptors | Not available |
Find and download the COA for your product by matching the lot number on the packaging.
| Lot Number | Certificate Type | Date | Item |
|---|---|---|---|
 I2201357 | Certificate of Analysis | May 20, 2026 | E122639 |
| I2201429 | Certificate of Analysis | May 20, 2026 | E122639 |
| I2201455 | Certificate of Analysis | May 20, 2026 | E122639 |
| J2112235 | Certificate of Analysis | Jul 07, 2023 | E122639 |
| J2112238 | Certificate of Analysis | Jul 07, 2023 | E122639 |
| J2112240 | Certificate of Analysis | Jul 07, 2023 | E122639 |
| J2112241 | Certificate of Analysis | Jul 07, 2023 | E122639 |
| Solubility | Miscible with water. |
|---|---|
| Sensitivity | Moisture Sensitive |
| Refractive Index | 1.429 |
| Flash Point(°F) | 147.2 °F |
| Flash Point(°C) | 67°C(152°F) |
| Boil Point(°C) | 83°C/22mm |
| Molecular Weight | 150.560 g/mol |
| XLogP3 | 1.300 |
| Hydrogen Bond Donor Count | 0 |
| Hydrogen Bond Acceptor Count | 3 |
| Rotatable Bond Count | 4 |
| Exact Mass | 150.008 Da |
| Monoisotopic Mass | 150.008 Da |
| Topological Polar Surface Area | 43.400 Ų |
| Heavy Atom Count | 9 |
| Formal Charge | 0 |
| Complexity | 121.000 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| The total count of all stereochemical bonds | 0 |
| Covalently-Bonded Unit Count | 1 |
| 1. Qi-Bo Li, Min Liao, Qing Liu, Tong Feng, Zhi-Yuan Xu, Chang-Hui Rui, Shang-Zhong Liu. (2019) Design, Synthesis, and Biological Activities of Novel 1,3,5-Trimethylpyrazole-Containing Malonamide Derivatives. MOLECULES, 24 (3): (562). [PMID:30717498] [10.3390/molecules24030562] |
