FzM1.8 - Moligand™, ≥98% , Allosteric modulator of FZD 4, CAS No.2204290-85-5, Allosteric modulator of FZD 4

CAS: 2204290-85-5 Cat. No.: F288778 Molecular Weight: 322.32

GRADE & PURITY Moligand™, ≥98%

Synonyms

3-Hydroxy-5-[[(2-Naphthalenylamino)carbonyl]amino]benzoic acid

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Specifications

Synonyms

3-Hydroxy-5-[[(2-Naphthalenylamino)carbonyl]amino]benzoic acid

Specifications & Purity

Moligand™, ≥98%

Biochemical and Physiological Mechanisms

FzM1.8 comes from FzM1 and is an allosteric agonist of FZD4 with a pEC50 of 6.4. FzM1.8 promotes TCF/LEF transcriptional activity in the absence of any WNT ligand, binds to FZD4, and activates WNT/ β- The catenin pathway. FzM1.8 binds to stable FZD4, incr

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Grade

Moligand™

Action Type

ALLOSTERIC MODULATOR

Mechanism of action

Allosteric modulator of FZD 4

Purity

≥98%

Names and Identifiers

• Pubchem Sid: 504773500
• Pubchem Sid Url: https://pubchem.ncbi.nlm.nih.gov/substance/504773500
• Canonical Smiles: C1=CC=C2C=C(C=CC2=C1)NC(=O)NC3=CC(=CC(=C3)C(=O)O)O
• IUPAC Name: 3-hydroxy-5-(naphthalen-2-ylcarbamoylamino)benzoic acid
• InChIKey: XGNNCRZDDAJBFU-UHFFFAOYSA-N
• INCHI: 1S/C18H14N2O4/c21-16-9-13(17(22)23)8-15(10-16)20-18(24)19-14-6-5-11-3-1-2-4-12(11)7-14/h1-10,21H,(H,22,23)(H2,19,20,24)
• Molecular Weight: 322.32
• Reaxy-Rn: 32313897
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=32313897&ln=

Associated Targets(Human)

FZD4 Tchem Frizzled-4 (1 Activities)

Discover Target: FZD4

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Chemical and Physical Properties

• Solubility: Solvent:DMSO, Max Conc. mg/mL: 32.23, Max Conc. mM: 100