GKA50 quarterhydrate , CAS No.G659443

CAS: G659443 Cat. No.: G659443 Molecular Weight: 469.01

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Overview

GKA50 quarterhydrate is a potent glucokinase activator ( EC 50 =33 nM at 5 mM glucose) and stimulates insulin release from mouse islets of Langerhans. GKA50 quarterhydrate is a glucose-like activator of beta-cell metabolism in rodent and human islets and

Appearance:Solid

In Vitro:GKA50 (0.01-100 μM; 24 hours) enhances INS-1 cell proliferation with EC 50 values ranging from 1 to 2 μM. GKA50 (1.2 μM+40 μM glucose; 2-4 days) treatment reduces apoptosis induced by chronic high glucose in INS-1 cells. GKA50 activates human gl

In Vivo:GKA50 (1-30mg/kg; p.o.) gives significant glucose lowering in an oral glucose tolerance test. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: High-fat-fed obese female Zucker (fa/fa) rats

Biological Activity:GKA50 quarterhydrate is a potent glucokinase activator ( EC 50 =33 nM at 5 mM glucose) and stimulates insulin release from mouse islets of Langerhans. GKA50 quarterhydrate is a glucose-like activator of beta-cell metabolism in rodent and human islets and

Specifications

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Action Type

ACTIVATOR

Names and Identifiers

• Molecular Weight: 469.01

Chemical and Physical Properties

• Solubility: DMSO : 46 mg/mL (98.08 mM; Need ultrasonic and warming)