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GSK-3β inhibitor 1 - ≥98% , CAS No.187325-53-7

CAS: 187325-53-7 Cat. No.: G651681 Molecular Weight: 222.24 PubChem CID: 5796182
COA
GSK-3β inhibitor 1 - ≥98% CAS No(187325-53-7) by Aladdin Scientific
AVAILABLE TO ORDER
GRADE & PURITY ≥98%
Synonyms
SR-01000594625 | GSK-3 | PIPAZETATE HYDROCHLORIDE [MART.] | EX-A7535 | BDBM50523811 | GSK-3beta inhibitor 1 | MS-23242 | AKOS002131629 | Pipazetatum [INN-Latin] | F77830 | SCHEMBL11748686 | EX-A6918 | 3-(Pyridin-2-ylmethylene)indolin-2-one | (3Z)-3-(2-pyr
Storage
Store at -20°C
Shipped In
Ice chest + Ice pads
★
 ·  off list, applied to all prices below.
Size
Status
Price
Qty
5mg
G651681-5mg
8-12 wks(?) Production requires sourcing of materials. We appreciate your patience and understanding.
$400.90
10mg
G651681-10mg
8-12 wks(?) Production requires sourcing of materials. We appreciate your patience and understanding.
$700.90
50mg
G651681-50mg
8-12 wks(?) Production requires sourcing of materials. We appreciate your patience and understanding.
$1,900.90
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SDS
Safety data
COA
Certificate
DS
Datasheet
SP
Spec sheet
Overview Specifications Names and Identifiers Documentation Advanced Data Taxonomic Classification 3D Structure Associated Targets(Human) Associated Targets(non-human) Mechanisms of Action Certificates（CoA,COO,BSE/TSE and Analysis Chart) Chemical and Physical Properties Documents & Articles Solution Calculators Reviews
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Why this grade

≥98% for sensitive chromatographic and analytical workflows requiring minimal baseline interference.

🌡

Storage & shipping

Store at -20°C Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.

📋

Quality documents

SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.

📚

Literature proof

Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.

Overview

GSK-3β inhibitor 1 (compound 3a) is a glycogen synthase kinase 3β (GSK-3β) inhibitor and demonstrates high antidiabetic efficacy, with an IC 50 of 4.9 nM

Form:Solid

IC50& Target:GSK-3β 4.9 nM (IC 50 )

Specifications

Synonyms
SR-01000594625 | GSK-3 | PIPAZETATE HYDROCHLORIDE [MART.] | EX-A7535 | BDBM50523811 | GSK-3beta inhibitor 1 | MS-23242 | AKOS002131629 | Pipazetatum [INN-Latin] | F77830 | SCHEMBL11748686 | EX-A6918 | 3-(Pyridin-2-ylmethylene)indolin-2-one | (3Z)-3-(2-pyr
Specifications & Purity
≥98%
Biochemical and Physiological Mechanisms
GSK-3β inhibitor 1 (compound 3a) is a glycogen synthase kinase 3β (GSK-3β) inhibitor and demonstrates high antidiabetic efficacy, with an IC 50 of 4.9 nM.
Storage
Store at -20°C
Shipped In
Ice chest + Ice pads
This product requires cold chain shipping. Ground and other economy services are not available.
Action Type
INHIBITOR
Purity
≥98%
Names and Identifiers
Canonical SmilesC1=CC=C2C(=C1)C(=CC3=CC=CC=N3)C(=O)N2
IUPAC Name(3Z)-3-(pyridin-2-ylmethylidene)-1H-indol-2-one
InChIKeyYKQONSWBHGBDSB-XFXZXTDPSA-N
INCHI1S/C14H10N2O/c17-14-12(9-10-5-3-4-8-15-10)11-6-1-2-7-13(11)16-14/h1-9H,(H,16,17)/b12-9-
Isomeric SMILES C1=CC=C2C(=C1)/C(=C/C3=CC=CC=N3)/C(=O)N2
Alternate CAS 3367-88-2
PubChem CID 5796182
NSC Number 116390
Molecular Weight 222.24

Documentation

📋 Safety Data Sheet (SDS)

Comprehensive hazard, handling, storage, and regulatory compliance document.

Download SDS →

✅ Certificate of Analysis (COA)

Lot-specific quality data. Enter your lot number to retrieve the exact COA.

Look up COA →

📊 Datasheet

Quick-reference summary of product specifications and applications.

View datasheet →

🔬 Specification Sheet

Full quality attributes and acceptance criteria for this grade.

View spec sheet →

Advanced Data

Taxonomic Classification

Taxonomy Tree

KingdomOrganic compounds
SuperclassOrganoheterocyclic compounds
ClassIndoles and derivatives
SubclassIndolines
Intermediate Tree Nodes Not available
Direct ParentIndolines
Alternative Parents Pyridines and derivatives  Benzenoids  Heteroaromatic compounds  Secondary carboxylic acid amides  Lactams  Azacyclic compounds  Organopnictogen compounds  Organonitrogen compounds  Organic oxides  Hydrocarbon derivatives  Carbonyl compounds  
Molecular FrameworkAromatic heteropolycyclic compounds
Substituents Dihydroindole - Pyridine - Benzenoid - Heteroaromatic compound - Carboxamide group - Lactam - Secondary carboxylic acid amide - Carboxylic acid derivative - Azacycle - Organopnictogen compound - Organic oxygen compound - Organooxygen compound - Organonitrogen compound - Carbonyl group - Organic nitrogen compound - Organic oxide - Hydrocarbon derivative - Aromatic heteropolycyclic compound
DescriptionThis compound belongs to the class of organic compounds known as indolines. These are compounds containing an indole moiety, which consists of pyrrolidine ring fused to benzene to form 2,3-dihydroindole.
External Descriptors Not available
3D Structure
Interactive Chemical Structure Model





Associated Targets(Human)
GSK3B Tclin Glycogen synthase kinase-3 beta (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
GSK3B Tclin Glycogen synthase kinase-3 beta (11785 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
MRC5 (9203 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
A549 (127892 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Associated Targets(non-human)
Trypanosoma brucei brucei (13300 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Rattus norvegicus (775804 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mechanisms of Action
Certificates（CoA,COO,BSE/TSE and Analysis Chart)
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:
Chemical and Physical Properties
SolubilityDMSO : 33.33 mg/mL (149.97 mM; Need ultrasonic)
Molecular Weight222.240 g/mol
XLogP31.900
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count2
Rotatable Bond Count1
Exact Mass222.079 Da
Monoisotopic Mass222.079 Da
Topological Polar Surface Area42.000 Ų
Heavy Atom Count17
Formal Charge0
Complexity337.000
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count1
Undefined Bond Stereocenter Count0
The total count of all stereochemical bonds1
Covalently-Bonded Unit Count1
Documents & Articles
Regulatory Framework and Biological Effects of the GSK3 Signaling Pathway
Categories: Technical articles
Tags:
glycogen metabolism Wnt/β-catenin inflammatory signaling GSK3 GSK3α GSK3β PI3K-AKT Cell fate
Solution Calculators
Reviews

Customer Reviews

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