Harman-d , CAS No.1216708-84-7

CAS: 1216708-84-7 Cat. No.: H1443675 Molecular Weight: 185.24 PubChem CID: 46781679

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Overview

Harman-d 3 is deuterium labeled Harmane. Harmane is a benzodiazepine receptor inhibitor ( IC 50 =7 μM), with IC 50 values for mACh , Opioid Receptor , MAO-A/B , and α2-adrenergic receptor of 24 μM, 2.8 μM, 0.5 μM, 5 μM, and 18 μM, respectively. Harmane also inhibits haloperidol and serotonin , with IC 50 values of 163 μM and 101 μM, respectively. Harmane inhibits the I1 imidazoline receptor ( IC 50 =30 nM) to reduce blood pressure and has antidepressant, anti-anxiety, anticonvulsant, and analgesic effects. Harmane inhibits dopamine biosynthesis by decreasing tyrosine hydroxylase (TH) activity and enhancing L-DOPA-induced cytotoxicity in PC12 cells. Additionally, Harmane can increase the mutagenic effect induced by 2-acetylaminofluorene (AAF).

Specifications

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Names and Identifiers

• Canonical Smiles: CC1=NC=CC2=C1NC3=CC=CC=C23
• IUPAC Name: 1-(trideuteriomethyl)-9H-pyrido[3,4-b]indole
• InChIKey: PSFDQSOCUJVVGF-FIBGUPNXSA-N
• INCHI: 1S/C12H10N2/c1-8-12-10(6-7-13-8)9-4-2-3-5-11(9)14-12/h2-7,14H,1H3/i1D3
• Isomeric SMILES: [2H]C([2H])([2H])C1=NC=CC2=C1NC3=CC=CC=C23
• PubChem CID: 46781679
• Molecular Weight: 185.24