Heptadecafluorononanoic Acid - ≥95%(GC) , CAS No.375-95-1

CAS: 375-95-1 Cat. No.: H157295 Molecular Weight: 464.08 Beilstein Registry Number: 1897290 EC Number: 206-801-3
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GRADE & PURITY ≥95%(GC)
Synonyms
2,2,3,3,4,4,5,5,6,6,7,7,8,8,9,9,9-Heptadecafluorononanoic acid | 2,2,3,3,4,4,5,5,6,6,7,7,8,8,9,9,9-Heptadecafluoro-Nonanoic Acid | DTXCID6011863 | NCGC00254315-01 | C8F17COOH | Q7168161 | Z56871598 | Heptadekafluornonansaeure | Heptadecafluorononanoic aci
Storage
Room temperature
Shipped In
Normal
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Size
Status
Price
Qty
1g
H157295-1g
2
$19.90
5g
H157295-5g
2
$77.90
10g
H157295-10g
3
$123.90
25g
H157295-25g
1
$259.90
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Why this grade

≥95%(GC) for sensitive chromatographic and analytical workflows requiring minimal baseline interference.

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Storage & shipping

Room temperature Ships Normal Check lot-specific COA for exact specifications.

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Quality documents

SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.

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Literature proof

Cited in 17 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.

Specifications

Synonyms
2, 2, 3, 3, 4, 4, 5, 5, 6, 6, 7, 7, 8, 8, 9, 9, 9-Heptadecafluorononanoic acid | 2, 2, 3, 3, 4, 4, 5, 5, 6, 6, 7, 7, 8, 8, 9, 9, 9-Heptadecafluoro-Nonanoic Acid | DTXCID6011863 | NCGC00254315-01 | C8F17COOH | Q7168161 | Z56871598 | Heptadekafluornonansaeure | Heptadecafluorononanoic aci
Specifications & Purity
≥95%(GC)
Storage
Room temperature
Shipped In
Normal
Purity
≥95%(GC)
Names and Identifiers
Canonical SmilesC(=O)(C(C(C(C(C(C(C(C(F)(F)F)(F)F)(F)F)(F)F)(F)F)(F)F)(F)F)(F)F)O
IUPAC Name2,2,3,3,4,4,5,5,6,6,7,7,8,8,9,9,9-heptadecafluorononanoic acid
InChIKeyUZUFPBIDKMEQEQ-UHFFFAOYSA-N
INCHI1S/C9HF17O2/c10-2(11,1(27)28)3(12,13)4(14,15)5(16,17)6(18,19)7(20,21)8(22,23)9(24,25)26/h(H,27,28)
Isomeric SMILES C(=O)(C(C(C(C(C(C(C(C(F)(F)F)(F)F)(F)F)(F)F)(F)F)(F)F)(F)F)(F)F)O
WGK Germany 3
Molecular Weight 464.08
Beilstein 1897290
Reaxy-Rn 1897287
Reaxys-RN_link_address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=1897287&ln=

Documentation

📋 Safety Data Sheet (SDS)

Comprehensive hazard, handling, storage, and regulatory compliance document.

Download SDS →

✅ Certificate of Analysis (COA)

Lot-specific quality data. Enter your lot number to retrieve the exact COA.

Look up COA →

📊 Datasheet

Quick-reference summary of product specifications and applications.

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🔬 Specification Sheet

Full quality attributes and acceptance criteria for this grade.

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Advanced Data

Taxonomic Classification

Taxonomy Tree

KingdomOrganic compounds
SuperclassOrganohalogen compounds
ClassAlkyl halides
SubclassAlkyl fluorides
Intermediate Tree Nodes Perfluoroalkyl carboxylic acid and derivatives
Direct ParentPerfluorooctanoic acid and derivatives
Alternative Parents Medium-chain fatty acids  Halogenated fatty acids  Alpha-halocarboxylic acids  Monocarboxylic acids and derivatives  Carboxylic acids  Organofluorides  Organic oxides  Hydrocarbon derivatives  Carbonyl compounds  
Molecular FrameworkAliphatic acyclic compounds
Substituents Perfluorooctanoic acid or derivatives - Medium-chain fatty acid - Halogenated fatty acid - Fatty acyl - Fatty acid - Alpha-halocarboxylic acid - Alpha-halocarboxylic acid or derivatives - Carboxylic acid derivative - Carboxylic acid - Monocarboxylic acid or derivatives - Hydrocarbon derivative - Organic oxygen compound - Carbonyl group - Organic oxide - Organofluoride - Organooxygen compound - Aliphatic acyclic compound
DescriptionThis compound belongs to the class of organic compounds known as perfluorooctanoic acid and derivatives. These are organic compounds containing an octyl chain attached to the C-alpha of a carboxylic acid group (or a derivative thereof), where all hydrogens of the octyl chain are replaced by fluorine atoms.
External Descriptors fluoroalkanoic acid
3D Structure
Interactive Chemical Structure Model





Associated Targets(Human)
ESR1 Tclin Estrogen receptor alpha (17718 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PPARG Tclin Peroxisome proliferator-activated receptor gamma (15191 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
THRB Tclin Thyroid hormone receptor beta-1 (7926 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
NR1H4 Tclin Bile acid receptor FXR (6228 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
TP53 Tchem Cellular tumor antigen p53 (48468 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Associated Targets(non-human)
Mus musculus (284745 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mechanisms of Action
Certificates(CoA,COO,BSE/TSE and Analysis Chart)
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

13 results found

Lot NumberCertificate TypeDateItem
G2208164Certificate of AnalysisApr 07, 2026 H157295
G2208274Certificate of AnalysisApr 07, 2026 H157295
D2623702Certificate of AnalysisNov 15, 2024 H157295
J2528013Certificate of AnalysisNov 15, 2024 H157295
K2412433Certificate of AnalysisNov 15, 2024 H157295
K2412434Certificate of AnalysisNov 15, 2024 H157295
K2412435Certificate of AnalysisNov 15, 2024 H157295
K2412436Certificate of AnalysisNov 15, 2024 H157295
K2413437Certificate of AnalysisNov 15, 2024 H157295
L2518060Certificate of AnalysisNov 15, 2024 H157295
D2425245Certificate of AnalysisMar 14, 2024 H157295
G2208275Certificate of AnalysisJul 13, 2022 H157295
J2421273Certificate of AnalysisJul 13, 2022 H157295

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Chemical and Physical Properties
Boil Point(°C)218°C
Melt Point(°C)59-62 °C
Molecular Weight464.080 g/mol
XLogP35.600
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count19
Rotatable Bond Count7
Exact Mass463.971 Da
Monoisotopic Mass463.971 Da
Topological Polar Surface Area37.300 Ų
Heavy Atom Count28
Formal Charge0
Complexity615.000
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
The total count of all stereochemical bonds0
Covalently-Bonded Unit Count1
Citations of This Product
References
1. Fan Dong, Fan Ge, Xinting Zhao, Daming Sun, Suyu Ren, Yan Wang, Feng Tan.  (2023)  Measurement of perfluoroalkyl substances in drinking water sources by DGT sampler with a novel fluorinated graphite binding gel.  SCIENCE OF THE TOTAL ENVIRONMENT,      [PMID:38159764] [10.1016/j.scitotenv.2023.169658]
2. Xu-Qin Ran, Shu-Ting Xu, Hai-Long Qian, Xiu-Ping Yan.  (2023)  Irreversible fluorine covalent organic framework based probe nanoelectrospray ionization mass spectrometry for direct and rapid determination of perfluoroalkyl carboxylic acids.  JOURNAL OF HAZARDOUS MATERIALS,      [PMID:37167864] [10.1016/j.jhazmat.2023.131584]
3. Yang Wang, Rongkai Ren, Fang Chen, Liming Jing, Zhenhua Tian, Zhijian Li, Jianzhi Wang, Chen Hou.  (2023)  Molecularly imprinted MOFs-driven carbon nanofiber for sensitive electrochemical detection and targeted electro-Fenton degradation of perfluorooctanoic acid.  SEPARATION AND PURIFICATION TECHNOLOGY,      [PMID:] [10.1016/j.seppur.2023.123257]
4. Hong Yin, Ruya Chen, Haibo Wang, Cory Schwarz, Haotian Hu, Baoyou Shi, Yili Wang.  (2022)  Co-occurrence of phthalate esters and perfluoroalkyl substances affected bacterial community and pathogenic bacteria growth in rural drinking water distribution systems.  SCIENCE OF THE TOTAL ENVIRONMENT,      [PMID:36155042] [10.1016/j.scitotenv.2022.158943]
5. Sihua Chen, Aimin Li, Lizhi Zhang, Jingming Gong.  (2015)  Molecularly imprinted ultrathin graphitic carbon nitride nanosheets–Based electrochemiluminescence sensing probe for sensitive detection of perfluorooctanoic acid.  ANALYTICA CHIMICA ACTA,      [PMID:26481989] [10.1016/j.aca.2015.09.022]
6. Jingming Gong, Tian Fang, Dinghua Peng, Aimin Li, Lizhi Zhang.  (2015)  A highly sensitive photoelectrochemical detection of perfluorooctanic acid with molecularly imprined polymer-functionalized nanoarchitectured hybrid of AgI–BiOI composite.  BIOSENSORS & BIOELECTRONICS,      [PMID:26092130] [10.1016/j.bios.2015.06.008]
7. Mingguo Peng, Yang Xu, Yao Wu, Xuewen Cai, Weihua Zhang, Lu Zheng, Erdeng Du, Jiajun Fu.  (2024)  Binding Affinity and Mechanism of Six PFAS with Human Serum Albumin: Insights from Multi-Spectroscopy, DFT and Molecular Dynamics Approaches.  Toxics,  12  (1): (43).  [PMID:38250999] [10.3390/toxics12010043]
8. Shi-Ya Peng, Ya-Di Yang, Rong Tian, Naihao Lu.  (2024)  Critical new insights into the interactions of hexafluoropropylene oxide-dimer acid (GenX or HFPO-DA) with albumin at molecular and cellular levels.  Journal of Environmental Sciences,      [PMID:39181681] [10.1016/j.jes.2024.02.011]
9. Jinni Zhang, Songtao Li, Xiaojing Li, Canrong Chen, Wen Xie, Yanhui Zhong, Zian Lin, Zongwei Cai.  (2025)  Determination of perfluoroalkyl carboxylic acids in mice serum and tissue by dispersive solid-phase extraction based on fluorine-functionalized covalent organic frameworks coupled with UPLC-MS/MS.  JOURNAL OF CHROMATOGRAPHY A,      [PMID:40024059] [10.1016/j.chroma.2025.465820]
10. Qi Jiang, Donghui Zhang, Naifan Hu, Yunfei Ma, Huibin Jin, Yunhao Zhao, Ming Zhang, Bin Li, Zhenzhen Huang, Bifeng Yuan, Ying Zhu, Jianbo Tian, Xiaoping Miao.  (2025)  Environmental Chemical-Induced Cardiometabolic Disorders: Combined Epidemiological and Experimental Evidence.  ENVIRONMENTAL SCIENCE & TECHNOLOGY,      [PMID:39977603] [10.1021/acs.est.4c09728]
11. Huan Liu, Siyuan Di, Yunkang Liu, Zihan Li, Pin Chen, Shukui Zhu.  (2024)  Magnetic fluorinated mesoporous metal-organic frameworks for rapid derivatization-assisted GC–MS analysis of perfluoroalkyl carboxylic acids in harsh water environment.  JOURNAL OF CHROMATOGRAPHY A,      [PMID:39729865] [10.1016/j.chroma.2024.465612]
12. Chunlin Zhai, Kunpeng Zhang, Yanling Liu, Shengji Xia.  (2025)  Enhancing selectivity of nanofiltration membranes for mineral ions and per- and polyfluoroalkyl substances via dual-component-assisted interfacial polymerization.  WATER RESEARCH,      [PMID:40749599] [10.1016/j.watres.2025.124315]
13. Xinting Zhao, Qinghua Zhou, Jiaxing Xie, Xin He, Yan Wang, Feng Tan.  (2025)  Effects of soil aging on distribution and desorption kinetics of per- and polyfluoroalkyl substances by diffusive gradients in thin films.  Journal of Environmental Sciences,      [PMID:] [10.1016/j.jes.2025.07.050]
14. Liu Yansheng, Sun Yukun, Wang Guofu, Jia Xiaobo, Zhou Jin, Li Hongqi, Li Hongli, Chan Haixin, Li Kang, Jin Zhicheng, Li Zhaoxu.  (2025)  Detection of PFAS and nanoplastics in serum by using Ag nanowires film SERS substrate with good reusability and sensitivity.  MICROCHIMICA ACTA,  192  (11): (1-12).  [PMID:41060456] [10.1007/s00604-025-07585-0]
15. Jian Song, Hai-Long Qian, Shu-Ting Xu, Cheng Yang, Xiu-Ping Yan.  (2025)  Room-Temperature Synthesis of a Multifunctional Covalent Organic Framework for Highly Efficient Extraction of Anionic Per- and Polyfluoroalkyl Substances.  ANALYTICAL CHEMISTRY,      [PMID:41348093] [10.1021/acs.analchem.5c05349]
16. Min Chen, Zhiwei Liang, Mengyuan Sun, Zhen Chen, Chun Peng, Suliman Khan, Mubbashar Abbas, Dongmei Chen, Shuyu Xie.  (2025)  Aryl hydrocarbon receptor-induced activation of AIM2 inflammasome is mediated by MOMP and MPT: A vital therapeutic pathway for inflammation.  Cell Reports,  44  (12):   [PMID:41385364] [10.1016/j.celrep.2025.116673]
17. Yanhua Zhang, Wen Yao, Jian Guo, Hongyuan Huang, Jie Yang, Jiahuang Qiu, Tianxin Li, Yubo Wei, Xinrong Guo.  (2026)  Polyphenylamine nanosheets-based dual-mode fluorescence probe for ultrasensitive detection of perfluoroalkyls in water environment.  ANALYTICA CHIMICA ACTA,      [PMID:41813339] [10.1016/j.aca.2026.345286]
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