GRADE & PURITY 10mM in DMSO

Synonyms

NSC 60672 | Cholan-24-oic acid, 3,6-dihydroxy-, (3α,5β,6α)-

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

Information

Hyodeoxycholic acid (HDCA) Hyodeoxycholic (HDCA, NSC 60672) acid is a secondary bile acid, one of the metabolic byproducts of intestinal bacteria.
In vitro

In vivo

Cell Data

cell lines：

Concentrations：

Incubation Time：

Powder Purity:≥95%

Specifications

Synonyms

NSC 60672 | Cholan-24-oic acid, 3, 6-dihydroxy-, (3α, 5β, 6α)-

Specifications & Purity

10mM in DMSO

Biochemical and Physiological Mechanisms

Hyodeoxycholic (HDCA, NSC 60672) acid is a secondary bile acid, one of the metabolic byproducts of intestinal bacteria.

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Product Properties

• ALogP: 4.9

Names and Identifiers

• Isomeric SMILES: C[C@H](CCC(=O)O)[C@H]1CC[C@@H]2[C@@]1(CC[C@H]3[C@H]2C[C@@H]([C@H]4[C@@]3(CC[C@H](C4)O)C)O)C
• WGK Germany: 3
• Molecular Weight: 392.57
• Reaxy-Rn: 2950246
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=2950246&ln=

Chemical and Physical Properties

• Melt Point(°C): 200-201°C

References

1. Cui Xiping, He Qiyi, Yang Huiyi, Chen Yingshan, Shen Ding, Eremin Sergei A., Mu Yunping, Zhao Suqing.  (2021)  Development of enzyme-free single-step immunoassays for glycocholic acid based on palladium nanoparticle-mediated signal generation.  ANALYTICAL AND BIOANALYTICAL CHEMISTRY,  413  (23): (5733-5742).  [PMID:34476526] [10.1007/s00216-021-03548-5]

2. Jiaxin Li, Yuqi Chen, Rui Li, Xianglong Zhang, Tao Chen, Fengyi Mei, Ruofan Liu, Meiling Chen, Yue Ge, Hongbin Hu, Rongjuan Wei, Zhenfeng Chen, Hongying Fan, Zhenhua Zeng, Yongqiang Deng, Haihua Luo, Shuiwang Hu, Shumin Cai, Feng Wu, Nengxian Shi, Zhang Wang, Yunong Zeng, Ming Xie, Yong Jiang, Zhongqing Chen, Wei Jia, Peng Chen.  (2023)  Gut microbial metabolite hyodeoxycholic acid targets the TLR4/MD2 complex to attenuate inflammation and protect against sepsis.  MOLECULAR THERAPY,      [PMID:36698311] [10.1016/j.ymthe.2023.01.018]

3. Jiating Zheng, Xiaoru Peng, Taifeng Zhu, Shuyao Huang, Chao Chen, Guosheng Chen, Shuqin Liu, Gangfeng Ouyang.  (2022)  Detection of bile acids in small volume human bile samples via an amino metal-organic framework composite based solid-phase microextraction probe.  JOURNAL OF CHROMATOGRAPHY A,      [PMID:36345074] [10.1016/j.chroma.2022.463634]

4. Ding Shen, Wei Hu, Suqing Zhao, Chuanbin Mao.  (2021)  Rapid Naked-Eye Detection of a Liver Disease Biomarker by Discovering Its Monoclonal Antibody to Functionalize Engineered Red-Colored Bacteria Probes.  ACS Omega,      [PMID:34870023] [10.1021/acsomega.1c04779]

5. Qiyi He, Yanxiong Fang, Huiyi Yang, Ding Shen, Yingshan Chen, Yingying Zhong, Xiangguang Li, Sergei A. Eremin, Xiping Cui, Suqing Zhao.  (2021)  Enhanced performance of a surface plasmon resonance-based immunosensor for the detection of glycocholic acid.  Analytical Methods,  13  (16): (1919-1924).  [PMID:33913980] [10.1039/D1AY00357G]

6. Ma Chongyang, Wang Xueqian, Xu Tian, Zhang Shuang, Liu Shuling, Zhai Changming, Wang Zisong, Mu Jie, Li Changxiang, Cheng Fafeng, Wang Qingguo.  (2020)  An Integrative Pharmacology-Based Analysis of Refined Qingkailing Injection Against Cerebral Ischemic Stroke: A Novel Combination of Baicalin, Geniposide, Cholic Acid, and Hyodeoxycholic Acid.  Frontiers in Pharmacology,      [PMID:32457601] [10.3389/fphar.2020.00519]

7. Yang Yang, Yang Cao, Yonghong Hu, Qi Zhang, Wenge Yang, Fei Shen.  (2015)  Thermodynamic analysis and correlation of solid–liquid equilibrium of hyodeoxycholic acid in ethanol + (acetone, ethyl acetate) binary solvent mixtures.  JOURNAL OF MOLECULAR LIQUIDS,      [PMID:] [10.1016/j.molliq.2015.07.005]

8. Juan Zhou, Yi-Qiao Xu, Sheng-Ya Guo, Chun-Qi Li.  (2014)  Rapid analysis of hypolipidemic drugs in a live zebrafish assay.  JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS,      [PMID:25497901] [10.1016/j.vascn.2014.12.002]

9. Yang Yang, Yonghong Hu, Qi Zhang, Limin Cheng, Cuicui Cao, Wenge Yang, Fei Shen.  (2014)  Experimental measurement and thermodynamic models for solid–liquid equilibrium of hyodeoxycholic acid in different organic solvents.  JOURNAL OF MOLECULAR LIQUIDS,      [PMID:] [10.1016/j.molliq.2014.12.007]

10. Hao Zhi, Zhongyan Wang, Xinyue Zhu, Wenhan Wu, Lu Yang, Yidong Dai, Zehua Wang, Ling Jiang, Yongmei Tan, Xiaodong Liu, Li Liu.  (2025)  Chronic liver injury decreases levels of cerebral carnitine and acetylcarnitine in rats partly due to the downregulation of OCTs and OCTN2 at the blood-brain barrier.  DRUG METABOLISM AND DISPOSITION,      [PMID:40300306] [10.1016/j.dmd.2025.100072]

11. Zhiye Yan, Weiwei Tang, Bin Li.  (2025)  Expanding Metabolome Coverage in LC–MS/MS Analysis through Hydralazine-Based Multifunctional Derivatization.  ANALYTICAL CHEMISTRY,      [PMID:41277254] [10.1021/acs.analchem.5c02101]