K-252a - Moligand™, 10 mM in DMSO , CAS No.99533-80-9

CAS: 99533-80-9 Cat. No.: K1499984 Molecular Weight: 467.47 EC Number: 640-127-4

GRADE & PURITY Moligand™, 10 mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

K-252a, a staurosporine analog, inhibits protein kinase , with IC 50 values of 470 nM, 140 nM, 270 nM, and 1.7 nM for PKC , PKA , Ca 2+ /calmodulin-dependent kinase type II, and phosphorylase kinase, respectively .K-252a is a potent inhibitor (IC 50 of 3 nM) of the tyrosine protein kinase ( TRK ) activity of the NGF receptor gp140trk, the product of the trk protooncogene.

Specifications

Specifications & Purity

Moligand™, 10 mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Grade

Moligand™

Action Type

INHIBITOR

Names and Identifiers

• Isomeric SMILES: C[C@@]12[C@](C[C@@H](O1)N3C4=CC=CC=C4C5=C6C(=C7C8=CC=CC=C8N2C7=C53)CNC6=O)(C(=O)OC)O
• WGK Germany: 3
• RTECS: NZ0550000
• Alternate CAS: 97161-97-2
• Molecular Weight: 467.47
• Reaxy-Rn: 6166559
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=6166559&ln=

Chemical and Physical Properties

• Melt Point(°C): 255°C-270°C