Kinetin - ≥99% , CAS No.525-79-1

CAS: 525-79-1 Cat. No.: K108960 Molecular Weight: 215.21 Beilstein Registry Number: 21703 EC Number: 208-382-2

GRADE & PURITY ≥99%

Synonyms

DivK1c_000011 | US9144538, Kinetin | DTXCID7015175 | N-(2-furylmethyl)-1H-purin-6-amine | 6-[(Furan-2-ylmethyl)amino]-9H-purine | KBio2_001544 | Kinetin (VAN) | N-(furan-2-ylmethyl)-9H-purin-6-amine | 2uy5 | HMS1570C19 | HMS561M13 | N6-(Furfurylamino)puri

Storage

Room temperature

Shipped In

Normal

Specifications

Synonyms

DivK1c_000011 | US9144538, Kinetin | DTXCID7015175 | N-(2-furylmethyl)-1H-purin-6-amine | 6-[(Furan-2-ylmethyl)amino]-9H-purine | KBio2_001544 | Kinetin (VAN) | N-(furan-2-ylmethyl)-9H-purin-6-amine | 2uy5 | HMS1570C19 | HMS561M13 | N6-(Furfurylamino)puri

Specifications & Purity

≥99%

Biochemical and Physiological Mechanisms

Description:
IC50 Value: N/A
Kinetin (N6-furfuryladenine) belongs to a group of plant growth hormones involved in cell division, differentiation and other physiological processes. Kinetin is one of the widely used components in numerous skin car

Storage

Room temperature

Shipped In

Normal

Note

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Purity

≥99%

Names and Identifiers

• Pubchem Sid: 504750718
• Pubchem Sid Url: https://pubchem.ncbi.nlm.nih.gov/substance/504750718
• Canonical Smiles: C1=COC(=C1)CNC2=NC=NC3=C2NC=N3
• IUPAC Name: N-(furan-2-ylmethyl)-7H-purin-6-amine
• InChIKey: QANMHLXAZMSUEX-UHFFFAOYSA-N
• INCHI: 1S/C10H9N5O/c1-2-7(16-3-1)4-11-9-8-10(13-5-12-8)15-6-14-9/h1-3,5-6H,4H2,(H2,11,12,13,14,15)
• Isomeric SMILES: C1=COC(=C1)CNC2=NC=NC3=C2NC=N3
• WGK Germany: 3
• RTECS: AU6270000
• Molecular Weight: 215.21
• Beilstein: 21703
• Reaxy-Rn: 21703
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=21703&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organoheterocyclic compounds
    • Class Imidazopyrimidines
      • Subclass Purines and purine derivatives
        • Level5 6-aminopurines
          • Level6 6-alkylaminopurines

• Kingdom: Organic compounds
• Superclass: Organoheterocyclic compounds
• Class: Imidazopyrimidines
• Subclass: Purines and purine derivatives
• Intermediate Tree Nodes: 6-aminopurines
• Direct Parent: 6-alkylaminopurines
• Alternative Parents: Secondary alkylarylamines Aminopyrimidines and derivatives Imidolactams Imidazoles Heteroaromatic compounds Furans Oxacyclic compounds Azacyclic compounds Organopnictogen compounds Organooxygen compounds Hydrocarbon derivatives
• Molecular Framework: Aromatic heteropolycyclic compounds
• Substituents: 6-alkylaminopurine - Aminopyrimidine - Secondary aliphatic/aromatic amine - Pyrimidine - Imidolactam - Azole - Furan - Imidazole - Heteroaromatic compound - Secondary amine - Azacycle - Oxacycle - Organopnictogen compound - Organic oxygen compound - Organooxygen compound - Organonitrogen compound - Organic nitrogen compound - Hydrocarbon derivative - Amine - Aromatic heteropolycyclic compound
• Description: This compound belongs to the class of organic compounds known as 6-alkylaminopurines. These are compounds that contain an alkylamine group attached at the 6-position of a purine. Purine is a bicyclic aromatic compound made up of a pyrimidine ring fused to an imidazole ring.
• External Descriptors: a small molecule

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Associated Targets(Human)

F2 Tclin Thrombin (11687 Activities)

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ESR1 Tclin Estrogen receptor alpha (17718 Activities)

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PGR Tclin Progesterone receptor (8562 Activities)

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CHRM2 Tclin Muscarinic acetylcholine receptor M2 (10671 Activities)

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HTR1A Tclin Serotonin 1a (5-HT1a) receptor (14969 Activities)

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ADRA2A Tclin Alpha-2a adrenergic receptor (9450 Activities)

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AR Tclin Androgen Receptor (11781 Activities)

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CHRM1 Tclin Muscarinic acetylcholine receptor M1 (12690 Activities)

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GABRA1 Tclin GABA receptor alpha-1 subunit (399 Activities)

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TSHR Tclin Thyroid stimulating hormone receptor (29986 Activities)

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MAOA Tclin Monoamine oxidase A (11911 Activities)

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DRD1 Tclin Dopamine D1 receptor (9720 Activities)

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ACHE Tclin Acetylcholinesterase (18204 Activities)

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PTGS1 Tclin Cyclooxygenase-1 (9233 Activities)

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SLC6A2 Tclin Norepinephrine transporter (10102 Activities)

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SLC6A4 Tclin Serotonin transporter (12625 Activities)

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ADRA1A Tclin Alpha-1a adrenergic receptor (8359 Activities)

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OPRM1 Tclin Mu opioid receptor (19785 Activities)

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DRD3 Tclin Dopamine D3 receptor (14368 Activities)

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SLC6A3 Tclin Dopamine transporter (10535 Activities)

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KCNH2 Tclin HERG (29587 Activities)

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PDE3A Tclin Phosphodiesterase 3A (3309 Activities)

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HTR2B Tclin Serotonin 2b (5-HT2b) receptor (10323 Activities)

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TBXA2R Tclin Thromboxane A2 receptor (5717 Activities)

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PDE4A Tclin Phosphodiesterase 4A (1943 Activities)

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ADORA3 Tchem Adenosine A3 receptor (15931 Activities)

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HRH3 Tclin Histamine H3 receptor (10389 Activities)

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KDR Tclin Vascular endothelial growth factor receptor 2 (20924 Activities)

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CYP2D6 Tclin Cytochrome P450 2D6 (33882 Activities)

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ALOX15 Tchem Arachidonate 15-lipoxygenase (7108 Activities)

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CYP1A2 Tchem Cytochrome P450 1A2 (26471 Activities)

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CYP2C9 Tchem Cytochrome P450 2C9 (32119 Activities)

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CYP2C19 Tchem Cytochrome P450 2C19 (29246 Activities)

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CYP3A4 Tclin Cytochrome P450 3A4 (53859 Activities)

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TP53 Tchem Cellular tumor antigen p53 (48468 Activities)

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HL-60 (67320 Activities)

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NHDF (1164 Activities)

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THP-1 (11052 Activities)

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HeLa (62764 Activities)

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HIF1A Tchem Hypoxia-inducible factor 1 alpha (6027 Activities)

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APEX1 Tchem DNA-(apurinic or apyrimidinic site) lyase (38016 Activities)

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CHIA Tchem Acidic mammalian chitinase (191 Activities)

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SMN1 Tchem Survival motor neuron protein (34246 Activities)

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GMNN Tbio Geminin (128009 Activities)

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SLCO1B1 Tchem Solute carrier organic anion transporter family member 1B1 (2672 Activities)

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SLCO1B3 Tchem Solute carrier organic anion transporter family member 1B3 (2517 Activities)

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MEN1 Tchem Menin/Histone-lysine N-methyltransferase MLL (48157 Activities)

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PINK1 Tbio Serine/threonine-protein kinase PINK1, mitochondrial (21 Activities)

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Associated Targets(non-human)

Hdac6 Histone deacetylase 6 (222 Activities)

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Nicotiana tabacum (382 Activities)

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Triticum aestivum (1582 Activities)

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Plasmodium falciparum (966862 Activities)

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RAW264.7 (28094 Activities)

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chiB1 Chitinase (8 Activities)

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rep Replicase polyprotein 1ab (378 Activities)

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BCHE Cholinesterase (8742 Activities)

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CTS1 Endochitinase (4 Activities)

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Amaranthus caudatus (12 Activities)

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Mechanisms of Action

Chemical and Physical Properties

• Molecular Weight: 215.210 g/mol
• XLogP3: 1.000
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 3
• Exact Mass: 215.081 Da
• Monoisotopic Mass: 215.081 Da
• Topological Polar Surface Area: 79.600 Ų
• Heavy Atom Count: 16
• Formal Charge: 0
• Complexity: 239.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1

References

1. Ling Li-Juan, Wang Meng, Pan Chuan-Qing, Tang Dao-Bang, Yuan En, Zhang Yuan-Yuan, Chen Ji-Guang, Peng Da-Yong, Yin Zhong-Ping.  (2023)  Investigating the induction of polyphenol biosynthesis in the cultured Cycolocarya paliurus cells and the stimulatory mechanism of co-induction with 5-aminolevulinic acid and salicylic acid.  Frontiers in Bioengineering and Biotechnology,      [PMID:36970633] [10.3389/fbioe.2023.1150842]

2. Mingwei Wang, Hailiang Nie, Dandan Han, Xiaoqiang Qiao, Hongyuan Yan, Shigang Shen.  (2019)  Cauliflower-like resin microspheres with tuneable surface roughness as solid-phase extraction adsorbent for efficient extraction and determination of plant growth regulators in cucumbers.  FOOD CHEMISTRY,      [PMID:31174757] [10.1016/j.foodchem.2019.05.130]