KS106 - ≥99% , CAS No.2408477-50-7

CAS: 2408477-50-7 Cat. No.: K647391 Molecular Weight: 474.29

GRADE & PURITY ≥99%

Storage

Store at 2-8°C,Protected from light,Desiccated

Shipped In

Wet ice

Overview

KS106 is a potent ALDH inhibitor with IC 50 s of 334, 2137, 360 nM for ALDH1A1, ALDH2 , and ALDH3A1, respectively. KS106 shows antiproliferative and anticancer effects with low low toxic.KS106 significantly increases ROS activity, lipid peroxidation and toxic aldehyde accumulation. KS106 induces apoptosis and cell cycle arrest at the G2/M phase

In Vitro

KS106 (compound 3h) (0-100 µM; 72 h) shows anti-proliferative activity with IC 50 s of 5.7, 5.7, 5.7, 4.9, 1.5, 2.6, 1.6, 1.7, 2.2, 20.7 µM for UACC 903, 1205 Lu, HCT116, HT29, NCIH929, U266, RPMI8226, MM.1R, MM.1S, FF2441 cells, respectively. KS106 (5 µM, 24 h) induces apoptosis and cell cycle arrest at the G2/M phase. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Apoptosis AnalysisCell Line: HCT116, HT29 cells Concentration: 5 µM Incubation Time: 24 h Result: Induced cell apoptosis. Cell Cycle AnalysisCell Line: HCT116 cells Concentration: 5 µM Incubation Time: 24 h Result: Induced cell cycle arrest at G2/M phase.

Form:Solid

IC50& Target:ALDH1 ALDH2 ALDH3

Specifications

Specifications & Purity

≥99%

Biochemical and Physiological Mechanisms

KS106 is a potent ALDH inhibitor with IC 50 s of 334, 2137, 360 nM for ALDH1A1, ALDH2 , and ALDH3A1, respectively. KS106 shows antiproliferative and anticancer effects with low low toxic.KS106 significantly increases ROS activity, lipid peroxidation and t

Storage

Store at 2-8°C, Protected from light, Desiccated

Shipped In

Wet ice

This product requires cold chain shipping. Ground and other economy services are not available.

Action Type

INHIBITOR

Purity

≥99%

Names and Identifiers

• Molecular Weight: 474.29

Chemical and Physical Properties

• Solubility: DMSO : 100 mg/mL (210.84 mM; Need ultrasonic)