KY19382 (A3051) - 2mM in DMSO , CAS No.2226664-93-1

CAS: 2226664-93-1 Cat. No.: K422672 Molecular Weight: 360.19 PubChem CID: 148959784

GRADE & PURITY 2mM in DMSO

Synonyms

2H-​Indol-​2-​one,5,​6-​dichloro-​3-​[1,​3-​dihydro-​3-​(methoxyimino)​-​2H-​indol-​2-​ylidene]​-​1,​3-​dihydro-

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

Information

KY19382 (A3051) is a potent and orally active dual inhibitor of CXXC5-DVL and GSK3β with IC50 of 19 nM and 10 nM, respectively. KY19382 activates Wnt/β-catenin signaling through inhibitory effects on both CXXC5-DVL interaction and GSK3β activity.

Specifications

Synonyms

2H-​Indol-​2-​one, 5, ​6-​dichloro-​3-​[1, ​3-​dihydro-​3-​(methoxyimino)​-​2H-​indol-​2-​ylidene]​-​1, ​3-​dihydro-

Specifications & Purity

2mM in DMSO

Biochemical and Physiological Mechanisms

KY19382 (A3051) is a Wnt/β-catenin signalling activator through inhibitory effects on both CXXC5–DVL interaction and GSK3β activity with IC50s of 19 nM and 10 nM, respectively.

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Names and Identifiers

• Canonical Smiles: CON=C1C2=CC=CC=C2N=C1C3=C(NC4=CC(=C(C=C43)Cl)Cl)O
• IUPAC Name: 5,6-dichloro-3-[(3Z)-3-methoxyiminoindol-2-yl]-1H-indol-2-ol
• InChIKey: TVZDUDDLASVAOM-JCMHNJIXSA-N
• INCHI: 1S/C17H11Cl2N3O2/c1-24-22-15-8-4-2-3-5-12(8)20-16(15)14-9-6-10(18)11(19)7-13(9)21-17(14)23/h2-7,21,23H,1H3/b22-15-
• PubChem CID: 148959784
• Molecular Weight: 360.19