L-Cystine dihydrochloride - Animal Free, ≥98% dry basis , CAS No.30925-07-6

CAS: 30925-07-6 Cat. No.: L476402 Molecular Weight: 313.22 EC Number: 250-391-9

GRADE & PURITY Animal Free, ≥98% dry basis

Synonyms

WFN1A47EIG | (2R)-2-amino-3-[[(2R)-2-amino-2-carboxyethyl]disulfanyl]propanoic acid;dihydrochloride | EN300-256900 | L-Cystine (dihydrochloride) | L-CYSTINE 2HCL | DTXSID101335748 | L-CYSTINE, HYDROCHLORIDE (1:2) | Cystine, dihydrochloride | L-Cystine dih

Storage

Room temperature

Overview

Description

Non-animal sourced L-cystine is used as a cell culture media component for the commercial biomanufacture of therapeutic recombinant proteins and monoclonal antibodies.

Specifications

Synonyms

WFN1A47EIG | (2R)-2-amino-3-[[(2R)-2-amino-2-carboxyethyl]disulfanyl]propanoic acid;dihydrochloride | EN300-256900 | L-Cystine (dihydrochloride) | L-CYSTINE 2HCL | DTXSID101335748 | L-CYSTINE, HYDROCHLORIDE (1:2) | Cystine, dihydrochloride | L-Cystine dih

Specifications & Purity

Animal Free, ≥98% dry basis

Biochemical and Physiological Mechanisms

Cystine is the dimeric form of cysteine. Cysteine is the source of disulfide linkages in proteins and has a role in sulfur transport. It undergoes rapid oxidation to form cystine at physiological pH. L-Cystine is crucial for oxygen production and low dens

Storage

Room temperature

Grade

Animal Free

Purity

≥98% dry basis

Names and Identifiers

• Pubchem Sid: 504768965
• Pubchem Sid Url: https://pubchem.ncbi.nlm.nih.gov/substance/504768965
• Canonical Smiles: C(C(C(=O)O)N)SSCC(C(=O)O)N.Cl.Cl
• IUPAC Name: (2R)-2-amino-3-[[(2R)-2-amino-2-carboxyethyl]disulfanyl]propanoic acid;dihydrochloride
• InChIKey: HHGZUQPEIHGQST-RGVONZFCSA-N
• INCHI: 1S/C6H12N2O4S2.2ClH/c7-3(5(9)10)1-13-14-2-4(8)6(11)12;;/h3-4H,1-2,7-8H2,(H,9,10)(H,11,12);2*1H/t3-,4-;;/m0../s1
• Isomeric SMILES: C([C@@H](C(=O)O)N)SSC[C@@H](C(=O)O)N.Cl.Cl
• Alternate CAS: 13059-63-7
• Molecular Weight: 313.22

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organic acids and derivatives
    • Class Carboxylic acids and derivatives
      • Subclass Amino acids, peptides, and analogues
        • Level5 Amino acids and derivatives
          • Level6 Alpha amino acids and derivatives
            • Level7 Cysteine and derivatives
              • Level8 L-cysteine-S-conjugates

• Kingdom: Organic compounds
• Superclass: Organic acids and derivatives
• Class: Carboxylic acids and derivatives
• Subclass: Amino acids, peptides, and analogues
• Intermediate Tree Nodes: Amino acids and derivatives - Alpha amino acids and derivatives - Cysteine and derivatives
• Direct Parent: L-cysteine-S-conjugates
• Alternative Parents: L-alpha-amino acids Dicarboxylic acids and derivatives Dialkyldisulfides Amino acids Sulfenyl compounds Carboxylic acids Organic oxides Monoalkylamines Hydrochlorides Hydrocarbon derivatives Carbonyl compounds
• Molecular Framework: Aliphatic acyclic compounds
• Substituents: L-cysteine-s-conjugate - Alpha-amino acid - L-alpha-amino acid - Dicarboxylic acid or derivatives - Amino acid - Organic disulfide - Dialkyldisulfide - Carboxylic acid - Sulfenyl compound - Organic nitrogen compound - Hydrochloride - Primary amine - Organosulfur compound - Organooxygen compound - Organonitrogen compound - Hydrocarbon derivative - Primary aliphatic amine - Organic oxide - Organic oxygen compound - Carbonyl group - Amine - Aliphatic acyclic compound
• Description: This compound belongs to the class of organic compounds known as l-cysteine-s-conjugates. These are compounds containing L-cysteine where the thio-group is conjugated.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Chemical and Physical Properties

• Solubility: 2 M HCl: 50mg/mL
• Sensitivity: Hygroscopic
• Specific Rotation[α]: -163 to -173 deg(C=1, 1mol/L HCl)
• Melt Point(°C): 228-232℃
• Molecular Weight: 313.200 g/mol
• Hydrogen Bond Donor Count: 6
• Hydrogen Bond Acceptor Count: 8
• Rotatable Bond Count: 7
• Exact Mass: 311.977 Da
• Monoisotopic Mass: 311.977 Da
• Topological Polar Surface Area: 177.000 Ų
• Heavy Atom Count: 16
• Formal Charge: 0
• Complexity: 192.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 2
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 3

XLogP3

References

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2. Yuan-Fu Ding, Tianlei Sun, Shengke Li, Qiaoxian Huang, Ludan Yue, Liangkui Zhu, Ruibing Wang.  (2019)  Oral Colon-Targeted Konjac Glucomannan Hydrogel Constructed through Noncovalent Cross-Linking by Cucurbit[8]uril for Ulcerative Colitis Therapy.  ACS Applied Bio Materials,      [PMID:35019421] [10.1021/acsabm.9b00676]

3. Yuting Zhang, Tao Hong, Menghui Wan, Yanbao Zhao, Lichao Peng.  (2024)  Fabrication of zein-coated brush-like silica nanocarriers for high foliage deposition and responsive release of pesticide.  COLLOIDS AND SURFACES B-BIOINTERFACES,      [PMID:38941651] [10.1016/j.colsurfb.2024.114061]

4. Nan Zhou, Jingzhi Chen, Meiqin Hu, Na Wen, Weijie Cai, Ping Li, Liding Zhao, Yaping Meng, Dongdong Zhao, Xiaotong Yang, Siyu Liu, Fangqian Huang, Cheng Zhao, Xinghua Feng, Zikai Jiang, Enjun Xie, Hongxu Pan, Zhidong Cen, Xinhui Chen, Wei Luo, Beisha Tang, Junxia Min, Fudi Wang, Junsheng Yang, Haoxing Xu.  (2025)  SLC7A11 is an unconventional H+ transporter in lysosomes.  CELL,      [PMID:40280132] [10.1016/j.cell.2025.04.004]